Astrocyte Activation and the Calcineurin/NFAT Pathway in Cerebrovascular Disease

Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology

(2018) Karen Horsburgh et al.   CLINICAL SCIENCE

Extinction of aversive taste memory homeostatically prevents the maintenance of in vivo insular cortex LTP: Calcineurin participation

(2018) Alejandro Rivera-Olvera et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Ca2+, Astrocyte Activation and Calcineurin/NFAT Signaling in Age-Related Neurodegenerative Diseases

(2018) Pradoldej Sompol et al.   Frontiers in Aging Neuroscience

Targeting NMDA receptors in stroke: new hope in neuroprotection

(2018) Qiu Jing Wu et al.   Molecular Brain

NFATc2 Modulates Microglial Activation in the AβPP/PS1 Mouse Model of Alzheimer’s Disease

(2017) Gunjan D. Manocha et al.   JOURNAL OF ALZHEIMERS DISEASE

Functional deficits induced by cortical microinfarcts

(2017) Philipp M Summers et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing Mice

(2017) Pradoldej Sompol et al.   JOURNAL OF NEUROSCIENCE

The role of Ca 2+ -calmodulin stimulated protein kinase II in ischaemic stroke – A potential target for neuroprotective therapies

(2017) John A.P. Rostas et al.   NEUROCHEMISTRY INTERNATIONAL

Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes

(2017) Noriko Itoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcineurin proteolysis in astrocytes: Implications for impaired synaptic function

(2016) Melanie M. Pleiss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-β-Induced Neuronal Death

(2016) Ana M. Fernandez et al.   JOURNAL OF ALZHEIMERS DISEASE

Blockade of Astrocytic Calcineurin/NFAT Signaling Helps to Normalize Hippocampal Synaptic Function and Plasticity in a Rat Model of Traumatic Brain Injury

(2016) Jennifer L. Furman et al.   JOURNAL OF NEUROSCIENCE

Reduced Efficacy of Anti-A  Immunotherapy in a Mouse Model of Amyloid Deposition and Vascular Cognitive Impairment Comorbidity

(2016) E. M. Weekman et al.   JOURNAL OF NEUROSCIENCE

Translational potential of astrocytes in brain disorders

(2016) Alexei Verkhratsky et al.   PROGRESS IN NEUROBIOLOGY

Astrocytes: a central element in neurological diseases

(2015) Milos Pekny et al.   ACTA NEUROPATHOLOGICA

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

(2015) Heather M. Snyder et al.   Alzheimers & Dementia

Diversity of astrocyte functions and phenotypes in neural circuits

(2015) Baljit S Khakh et al.   NATURE NEUROSCIENCE

Sustained Down-regulation of β-Dystroglycan and Associated Dysfunctions of Astrocytic Endfeet in Epileptic Cerebral Cortex

(2014) Asako Gondo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcineurin and glial signaling: neuroinflammation and beyond

(2014) Jennifer L Furman et al.   Journal of Neuroinflammation

GLT-1 transporter: An effective pharmacological target for various neurological disorders

(2014) Neha Soni et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression

(2014) Giulia E. Tyzack et al.   Nature Communications

Mislocalization of AQP4 precedes chronic seizures in the kainate model of temporal lobe epilepsy

(2013) Silje Alvestad et al.   EPILEPSY RESEARCH

Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB

(2013) Dmitry Lim et al.   GLIA

NFATc3 promotes Ca2+-dependent MMP3 expression in astroglial cells

(2013) Fernando Neria et al.   GLIA

Microglial Phenotype Is Regulated by Activity of the Transcription Factor, NFAT (Nuclear Factor of Activated T Cells)

(2013) K. Nagamoto-Combs et al.   JOURNAL OF NEUROSCIENCE

Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury

(2013) I. B. Wanner et al.   JOURNAL OF NEUROSCIENCE

Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice

(2012) Andrew W. Kraft et al.   FASEB JOURNAL

Regulator of calcineurin 1 (Rcan1) has a protective role in brain ischemia/reperfusion injury

(2012) Mónica Sobrado et al.   Journal of Neuroinflammation

Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer's Disease

(2012) J. L. Furman et al.   JOURNAL OF NEUROSCIENCE

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Proteomic Analysis of Alterations Induced by Perinatal Hypoxic–Ischemic Brain Injury

(2012) Katja Rosenkranz et al.   JOURNAL OF PROTEOME RESEARCH

Over-Expression of DSCR1 Protects against Post-Ischemic Neuronal Injury

(2012) Vanessa H. Brait et al.   PLoS One

A Role for Calcineurin in Alzheimers Disease

(2011) Lindsay C. Reese et al.   Current Neuropharmacology

Role of calcineurin in neurodegeneration produced by misfolded proteins and endoplasmic reticulum stress

(2011) Abhisek Mukherjee et al.   CURRENT OPINION IN CELL BIOLOGY

Capillary blood flow around microglial somata determines dynamics of microglial processes in ischemic conditions

(2011) Tadashi Masuda et al.   GLIA

Reconsolidation or Extinction: Transcription Factor Switch in the Determination of Memory Course after Retrieval

(2011) V. de la Fuente et al.   JOURNAL OF NEUROSCIENCE

Regulation of the phosphatase calcineurin by insulin-like growth factor I unveils a key role of astrocytes in Alzheimer's pathology

(2011) A M Fernandez et al.   MOLECULAR PSYCHIATRY

Calcium, ischemia and excitotoxicity

(2010) Kinga Szydlowska et al.   CELL CALCIUM

Response of transcription factor NFATc3 to excitotoxic and traumatic brain insults: Identification of a subpopulation of reactive astrocytes

(2010) María C. Serrano-Pérez et al.   GLIA

Recurrent Spontaneous Spreading Depolarizations Facilitate Acute Dendritic Injury in the Ischemic Penumbra

(2010) W. C. Risher et al.   JOURNAL OF NEUROSCIENCE

Cognitive Decline in Alzheimer's Disease Is Associated with Selective Changes in Calcineurin/NFAT Signaling

(2009) H. M. Abdul et al.   JOURNAL OF NEUROSCIENCE

Alternative splicing and expression of human and mouse NFAT genes

(2008) Hanna Vihma et al.   GENOMICS

Calcium/calcineurin signaling in primary cortical astrocyte cultures: Rcan1-4 and cyclooxygenase-2 as NFAT target genes

(2008) Andrea Canellada et al.   GLIA

GFAPpromoter elements required for region-specific and astrocyte-specific expression

(2008) Youngjin Lee et al.   GLIA

Probing the molecular mechanisms of neuronal degeneration: importance of mitochondrial dysfunction and calcineurin activation

(2008) Hiroyuki Uchino et al.   Journal of Anesthesia

Interleukin-1β-dependent Signaling between Astrocytes and Neurons Depends Critically on Astrocytic Calcineurin/NFAT Activity

(2008) Michelle A. Sama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of the establishment of aversive memory by calcineurin and Zif268

(2008) Karsten Baumgärtel et al.   NATURE NEUROSCIENCE

Coupling of Neural Activity to Blood Flow in Olfactory Glomeruli Is Mediated by Astrocytic Pathways

(2008) Gabor C. Petzold et al.   NEURON

NFAT signaling in neural development and axon growth

(2007) Tuan Nguyen et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE