661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively

Major review: Molecular genetics of primary open-angle glaucoma

(2017) Yutao Liu et al.   EXPERIMENTAL EYE RESEARCH

Genetics of glaucoma

(2017) Janey L. Wiggs et al.   HUMAN MOLECULAR GENETICS

CCR3 Is Associated with the Death of a Photoreceptor Cell-line Induced by Light Exposure

(2017) Yoshiki Kuse et al.   Frontiers in Pharmacology

Defects in autophagy caused by glaucoma-associated mutations in optineurin

(2016) Kapil Sirohi et al.   EXPERIMENTAL EYE RESEARCH

A Disease-associated Mutant of NLRC4 Shows Enhanced Interaction with SUG1 Leading to Constitutive FADD-dependent Caspase-8 Activation and Cell Death

(2016) Akhouri Kishore Raghawan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of optineurin mutants on SH-SY5Y cell survival

(2016) Min Zhu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Significance of optineurin mutations in glaucoma and other diseases

(2016) Yuriko Minegishi et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Visual impairment in an optineurin mouse model of primary open-angle glaucoma

(2015) Henry C. Tseng et al.   NEUROBIOLOGY OF AGING

Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate

(2015) Fuguo Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin

(2015) Kapil Sirohi et al.   PLoS One

Induction of Neuronal Morphology in the 661W Cone Photoreceptor Cell Line with Staurosporine

(2015) Alex F. Thompson et al.   PLoS One

Neuronal Cell Death in the Inner Retina and the Influence of Vascular Endothelial Growth Factor Inhibition in a Diabetic Rat Model

(2014) Hae-Young Lopilly Park et al.   AMERICAN JOURNAL OF PATHOLOGY

E50K-OPTN-Induced Retinal Cell Death Involves the Rab GTPase-Activating Protein, TBC1D17 Mediated Block in Autophagy

(2014) Madhavi Latha Somaraju Chalasani et al.   PLoS One

M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells

(2013) Kapil Sirohi et al.   Autophagy

Enhanced optineurin E50K–TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma

(2013) Yuriko Minegishi et al.   HUMAN MOLECULAR GENETICS

The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina

(2013) Allen R. Rodriguez et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Optineurin suppression causes neuronal cell death via NF-κB pathway

(2013) Mayumi Akizuki et al.   JOURNAL OF NEUROCHEMISTRY

Optic neuropathies: characteristic features and mechanisms of retinal ganglion cell loss

(2013) Yuyi You et al.   REVIEWS IN THE NEUROSCIENCES

Anatomical and functional damage in experimental glaucoma

(2012) M Agudo-Barriuso et al.   CURRENT OPINION IN PHARMACOLOGY

Variants in ASB10 are associated with open-angle glaucoma

(2011) F. Pasutto et al.   HUMAN MOLECULAR GENETICS

Copy number variations on chromosome 12q14 in patients with normal tension glaucoma

(2011) John H. Fingert et al.   HUMAN MOLECULAR GENETICS

Evidence of outer retinal changes in glaucoma patients as revealed by ultrahigh-resolution in vivo retinal imaging

(2010) S. S. Choi et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Changes in the inner and outer retinal layers after acute increase of the intraocular pressure in adult albino Swiss mice

(2010) Nicolás Cuenca et al.   EXPERIMENTAL EYE RESEARCH

Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice

(2010) Zai-Long Chi et al.   HUMAN MOLECULAR GENETICS

Processing of Optineurin in Neuronal Cells

(2010) Xiang Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations of optineurin in amyotrophic lateral sclerosis

(2010) Hirofumi Maruyama et al.   NATURE

Morphologies of mouse retinal ganglion cells expressing transcription factors Brn3a, Brn3b, and Brn3c: Analysis of wild type and mutant cells using genetically-directed sparse labeling

(2010) Tudor Constantin Badea et al.   VISION RESEARCH

Heterozygous NTF4 Mutations Impairing Neurotrophin-4 Signaling in Patients with Primary Open-Angle Glaucoma

(2009) Francesca Pasutto et al.   AMERICAN JOURNAL OF HUMAN GENETICS