Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology

ISDoT: in situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix

(2017) Alejandro E Mayorca-Guiliani et al.   NATURE MEDICINE

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

(2017) Claire Vennin et al.   Science Translational Medicine

Disease Modeling in Stem Cell-Derived 3D Organoid Systems

(2017) Devanjali Dutta et al.   TRENDS IN MOLECULAR MEDICINE

Fibronectin-guided migration of carcinoma collectives

(2017) Sandeep Gopal et al.   Nature Communications

Organoids: Modeling Development and the Stem Cell Niche in a Dish

(2016) Kai Kretzschmar et al.   DEVELOPMENTAL CELL

SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland

(2016) Emilia Peuhu et al.   EMBO JOURNAL

Generating and characterizing the mechanical properties of cell-derived matrices using atomic force microscopy

(2016) Marta Tello et al.   METHODS

3-Dimensional Patient-Derived Lung Cancer Assays Reveal Resistance to Standards-of-Care Promoted by Stromal Cells but Sensitivity to Histone Deacetylase Inhibitors

(2016) D. Onion et al.   MOLECULAR CANCER THERAPEUTICS

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

(2016) Giampaolo Bianchini et al.   Nature Reviews Clinical Oncology

Screening out irrelevant cell-based models of disease

(2016) Peter Horvath et al.   NATURE REVIEWS DRUG DISCOVERY

The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2

(2016) I Roth et al.   ONCOGENE

Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases

(2016) N. N. Rahbari et al.   Science Translational Medicine

Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue

(2016) Zahra Erami et al.   Cell Reports

Subtyping Pancreatic Cancer

(2015) Andrew V. Biankin et al.   CANCER CELL

The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis

(2015) Lisa M. Ooms et al.   CANCER CELL

A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis

(2015) Jasreen Kular et al.   DEVELOPMENTAL CELL

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy

(2015) Bryan W Miller et al.   EMBO Molecular Medicine

Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

(2015) C. D. Madsen et al.   EMBO REPORTS

Annexin A6 and Late Endosomal Cholesterol Modulate Integrin Recycling and Cell Migration

(2015) Ana García-Melero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin decreases breast cancer metastasis by modulating Rho-associated kinase protein-1 expression

(2015) Thaiz Ferraz Borin et al.   JOURNAL OF PINEAL RESEARCH

Whole genomes redefine the mutational landscape of pancreatic cancer

(2015) Nicola Waddell et al.   NATURE

Fractal heterogeneity in minimal matrix models of scars modulates stiff-niche stem-cell responses via nuclear exit of a mechanorepressor

(2015) P. C. Dave P. Dingal et al.   NATURE MATERIALS

The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking

(2015) Leila Belle et al.   Science Signaling

The cross-talk of LDL-cholesterol with cell motility: Insights from the Niemann Pick Type C1 mutation and altered integrin trafficking

(2015) Monira Hoque et al.   Cell Adhesion & Migration

Characteristics of Pepsin-Solubilised Collagen from the Skin of Splendid Squid (Loligo formosana)

(2015) Phanat Kittiphattanabawon et al.   Journal of Chemistry

The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking

(2015) Leila Belle et al.   Science Signaling

Target Modulation by a Kinase Inhibitor Engineered to Induce a Tandem Blockade of the Epidermal Growth Factor Receptor (EGFR) and c-Src: The Concept of Type III Combi-Targeting

(2015) Suman Rao et al.   PLoS One

Macromolecular Crowding Meets Tissue Engineering by Self-Assembly: A Paradigm Shift in Regenerative Medicine

(2014) Abhigyan Satyam et al.   ADVANCED MATERIALS

Muscular anatomy of the tail of the western grey kangaroo, Macropus fuliginosus

(2014) Rebekah Dawson et al.   AUSTRALIAN JOURNAL OF ZOOLOGY

Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment

(2014) D. Herrmann et al.   CARCINOGENESIS

Gemcitabine and CHK1 Inhibition Potentiate EGFR-Directed Radioimmunotherapy against Pancreatic Ductal Adenocarcinoma

(2014) F. Al-Ejeh et al.   CLINICAL CANCER RESEARCH

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

Extracellular matrix assembly: a multiscale deconstruction

(2014) Janna K. Mouw et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Three-dimensional organotypic culture: experimental models of mammalian biology and disease

(2014) Eliah R. Shamir et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AtomicJ: An open source software for analysis of force curves

(2014) Paweł Hermanowicz et al.   REVIEW OF SCIENTIFIC INSTRUMENTS

MYPT1 regulates contractility and microtubule acetylation to modulate integrin adhesions and matrix assembly

(2014) E. Emily Joo et al.   Nature Communications

Cholesterol Regulates Syntaxin 6 Trafficking at trans-Golgi Network Endosomal Boundaries

(2014) Meritxell Reverter et al.   Cell Reports

An Improved Method for the Preparation of Type I Collagen From Skin

(2014) Christina A. Pacak et al.   Jove-Journal of Visualized Experiments

Intravital FLIM-FRET Imaging Reveals Dasatinib-Induced Spatial Control of Src in Pancreatic Cancer

(2013) M. Nobis et al.   CANCER RESEARCH

Fibroblast activation protein expression by stromal cells and tumor-associated macrophages in human breast cancer

(2013) Julia Tchou et al.   HUMAN PATHOLOGY

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

(2012) Michael A Jacobetz et al.   GUT

Nonpolarized signaling reveals two distinct modes of 3D cell migration

(2012) Ryan J. Petrie et al.   JOURNAL OF CELL BIOLOGY

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

(2012) Andrew V. Biankin et al.   NATURE

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

(2012) Ravid Straussman et al.   NATURE

Second harmonic generation microscopy for quantitative analysis of collagen fibrillar structure

(2012) Xiyi Chen et al.   Nature Protocols

Patient-derived tumour xenografts as models for oncology drug development

(2012) John J. Tentler et al.   Nature Reviews Clinical Oncology

Microstructural analysis of collagen and elastin fibres in the kangaroo articular cartilage reveals a structural divergence depending on its local mechanical environment

(2012) B. He et al.   OSTEOARTHRITIS AND CARTILAGE

Experimental investigation of collagen waviness and orientation in the arterial adventitia using confocal laser scanning microscopy

(2011) R. Rezakhaniha et al.   Biomechanics and Modeling in Mechanobiology

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

Hedgehog Overexpression Is Associated with Stromal Interactions and Predicts for Poor Outcome in Breast Cancer

(2011) S. A. O'Toole et al.   CANCER RESEARCH

Retinoic Acid–Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt–β-Catenin Signaling to Slow Tumor Progression

(2011) Fieke E.M. Froeling et al.   GASTROENTEROLOGY

Fibroblasts and Myofibroblasts: What Are We Talking About?

(2011) Jennifer Baum et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

(2011) Colin R. Lindsay et al.   Nature Communications

Organotypic Collagen I Assay: A Malleable Platform to Assess Cell Behaviour in a 3-Dimensional Context

(2011) Paul Timpson et al.   Jove-Journal of Visualized Experiments

Pore size variable type I collagen gels and their interaction with glioma cells

(2010) Ya-li Yang et al.   BIOMATERIALS

4-Methylumbelliferone inhibits tumour cell growth and the activation of stromal hyaluronan synthesis by melanoma cell-derived factors

(2010) M. Edward et al.   BRITISH JOURNAL OF DERMATOLOGY

Nuclear mechanics during cell migration

(2010) Peter Friedl et al.   CURRENT OPINION IN CELL BIOLOGY

Pancreatic cancer organotypic cultures

(2010) Fieke E.M. Froeling et al.   JOURNAL OF BIOTECHNOLOGY

Tissue section AFM: In situ ultrastructural imaging of native biomolecules

(2010) Helen K. Graham et al.   MATRIX BIOLOGY

A Novel Organotypic Model Mimics the Tumor Microenvironment

(2009) Sini Nurmenniemi et al.   AMERICAN JOURNAL OF PATHOLOGY

Organotypic Culture Model of Pancreatic Cancer Demonstrates that Stromal Cells Modulate E-Cadherin, β-Catenin, and Ezrin Expression in Tumor Cells

(2009) Fieke E.M. Froeling et al.   AMERICAN JOURNAL OF PATHOLOGY

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments

(2009) S. A. Bustin et al.   CLINICAL CHEMISTRY

Scoring of collagen organization in healthy and diseased human dermis by multiphoton microscopy

(2009) Riccardo Cicchi et al.   Journal of Biophotonics

A role for pericytes as microenvironmental regulators of human skin tissue regeneration

(2009) Sophie Paquet-Fifield et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

(2009) J. P. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

The actin cytoskeleton in cancer cell motility

(2008) Michael F. Olson et al.   CLINICAL & EXPERIMENTAL METASTASIS

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols