The role of reactive oxygen species and subsequent DNA-damage response in the emergence of resistance towards resveratrol in colon cancer models

Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention

(2014) D. Lissa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Colorectal cancer

(2013) Hermann Brenner et al.   LANCET

Resveratrol metabolites inhibit human metastatic colon cancer cells progression and synergize with chemotherapeutic drugs to induce cell death

(2013) Virginie Aires et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Immunomodulation and Anti-inflammatory Roles of Polyphenols as Anticancer Agents

(2012) Francois Ghiringhelli et al.   Anti-Cancer Agents in Medicinal Chemistry

Cellular senescence and cancer chemotherapy resistance

(2012) Ryan R. Gordon et al.   DRUG RESISTANCE UPDATES

Endocytosis of Resveratrol via Lipid Rafts and Activation of Downstream Signaling Pathways in Cancer Cells

(2011) Didier Colin et al.   Cancer Prevention Research

Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase

(2011) Samuel McNeely et al.   CELL CYCLE

Resveratrol Selectively Induces DNA Damage, Independent of Smad4 Expression, in Its Efficacy against Human Head and Neck Squamous Cell Carcinoma

(2011) Alpna Tyagi et al.   CLINICAL CANCER RESEARCH

Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation

(2010) A. Puissant et al.   CANCER RESEARCH

Clinical Pharmacology of Resveratrol and Its Metabolites in Colorectal Cancer Patients

(2010) K. R. Patel et al.   CANCER RESEARCH

Weak p53 permits senescence during cell cycle arrest

(2010) Olga V. Leontieva et al.   CELL CYCLE

The Mismatch Repair System Modulates Curcumin Sensitivity through Induction of DNA Strand Breaks and Activation of G2-M Checkpoint

(2010) Z. Jiang et al.   MOLECULAR CANCER THERAPEUTICS

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes

(2010) F Al-Ejeh et al.   ONCOGENE

The p16INK4A tumor suppressor regulates cellular oxidative stress

(2010) N C Jenkins et al.   ONCOGENE

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

Putative chemopreventive molecules can increase Nrf2-regulated cell defense in some human cancer cell lines, resulting in resistance to common cytotoxic therapies

(2009) Liangao Hu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

NADPH oxidases 1 and 4 mediate cellular senescence induced by resveratrol in human endothelial cells

(2009) Yvonne D.C. Schilder et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of resveratrol analogs on cell cycle progression, cell cycle associated proteins and 5fluoro-uracil sensitivity in human derived colon cancer cells

(2009) Didier Colin et al.   INTERNATIONAL JOURNAL OF CANCER

Pharmacokinetics ofTrans-resveratrol Following Repeated Administration in Healthy Elderly and Young Subjects

(2009) Teresa Nunes et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers

(2009) Luis Almeida et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy

(2008) Pierre-Emmanuel Puig et al.   CELL BIOLOGY INTERNATIONAL

Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cells

(2008) Malgorzata A. Sliwinska et al.   MECHANISMS OF AGEING AND DEVELOPMENT