Article
Cardiac & Cardiovascular Systems
Gabriele Brosolo, Andrea Da Porto, Luca Bulfone, Antonio Vacca, Nicole Bertin, Cinzia Vivarelli, Leonardo A. Sechi, Cristiana Catena
Summary: This study examines the relationship between arterial stiffening and the hemostatic and fibrinolytic system. The results show a significant association between arterial stiffening and spontaneous activation of the hemostatic and fibrinolytic system in middle-aged hypertensive patients, independent of age, body mass index, etc.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Anesthesiology
Mirjam Bachler, Johannes Boesch, Daniel P. Stuerzel, Tobias Hell, Andreas Giebl, Mathias Stroehle, Sebastian J. Klein, Volker Schaefer, Georg F. Lehner, Michael Joannidis, Claudius Thome, Dietmar Fries
Summary: Critically ill COVID-19 patients exhibit a hypercoagulable state with impaired fibrinolysis, characterized by increased clot firmness and decreased fibrinolytic response in whole blood coagulation tests. This hypofibrinolytic state may be at least partially due to a decreased fibrinolytic response.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Pharmacology & Pharmacy
Kirstin Meiners, Prisca Hamm, Marcus Gutmann, Jan Niedens, Agnieszka Nowak-Krol, Salvador Pane, Tessa Luehmann
Summary: The study developed three polyethylene glycol (PEG)ylated tPA bioconjugates based on the recombinant human tPA drug Alteplase using site-specific conjugation strategies. These bioconjugates showed improved proteolytic activity, slower inhibition kinetics by PAI-1, and increased hydrodynamic size.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Biology
Matthieu Lepine, Sara Douceau, Gabrielle Devienne, Paul Prunotto, Sophie Lenoir, Caroline Regnauld, Elsa Pouettre, Juliette Piquet, Laurent Lebouvier, Yannick Hommet, Eric Maubert, Veronique Agin, Bertrand Lambolez, Bruno Cauli, Carine Ali, Denis Vivien
Summary: The study reveals that tPA released from cortical FS-PV interneurons in the central nervous system can reduce the density of PNNs by degrading CSPGs. This finding provides valuable insights into the control of brain plasticity.
Article
Multidisciplinary Sciences
Kseniya Rubina, Anna Shmakova, Aslan Shabanov, Yulii Andreev, Natalia Borovkova, Vladimir Kulabukhov, Anatoliy Evseev, Konstantin Popugaev, Sergey Petrikov, Ekaterina Semina
Summary: This study analyzed the clinical, laboratory, and CT scan characteristics associated with a high risk of COVID-19-related death in severely-ill patients in Russia. The findings suggest new prognostic factors that can be used as early predictors of a severe course of COVID-19 for prevention or timely treatment trials.
Article
Hematology
Anna Falanga, Marina Marchetti, Laura Russo
Summary: Cancer patients often exhibit a hypercoagulable state and increased risk of thrombotic events, with common implications in malignant cell growth, invasion, metastatic spread, and tumor-induced angiogenesis. Studies have shown that alterations in hemostatic components play a predictive role in cancer prognosis, with research focusing on clotting activation biomarkers and their relation to different cancer outcomes.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2021)
Review
Cell Biology
Celia Seillier, Pauline Helie, Gautier Petit, Denis Vivien, Diego Clemente, Brigitte Le Mauff, Fabian Docagne, Olivier Toutirais
Summary: tPA is a serine protease that plays a crucial role in fibrinolysis and immune processes. It has the potential to regulate inflammatory diseases and has functions in adaptive immunity, particularly in T cells and antigen presenting cells.
CELLULAR IMMUNOLOGY
(2022)
Article
Hematology
Tae Ito, Yuko Suzuki, Hideto Sano, Naoki Honkura, Francis J. Castellino, Tetsumei Urano
Summary: The study demonstrates the existence of three distinct forms of high-molecular-weight complexes between tPA and PAI-1. Peptide sequence analysis revealed that these complexes consist of nonacylated-enzyme inhibitor complexes, with only a fraction of the population releasing free tPA under physiological conditions.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Nutrition & Dietetics
Chao Zhang, Jonathan Salamon, Ren Zhang
Summary: This study investigated the relationship between fibrinogen and tissue plasminogen activator levels and changes in adipose tissue, finding that tissue plasminogen activator levels were more affected during weight loss, while fibrinogen levels remained relatively stable.
Article
Neurosciences
Antoine Anfray, Camille Brodin, Antoine Drieu, Fanny Potzeha, Basile Dalarun, Veronique Agin, Denis Vivien, Cyrille Orset
Summary: The commercial form of rtPA has similar effects in promoting fibrinolysis and tissue reperfusion, with two-chains rtPA showing less efficiency compared to single chain rtPA, and associated with more severe blood brain barrier damage.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Cell Biology
Koji Sugioka, Teruo Nishida, Aya Kodama-Takahashi, Junko Murakami, Fukutaro Mano, Kiyotaka Okada, Masahiko Fukuda, Shunji Kusaka
Summary: Corneal fibroblasts are regulated by collagen, and the targeting of Endo180 and uPA receptor may play a role in the regulation of alpha-SMA expression in a manner dependent on TGF-beta signaling. uPA deficiency may promote the interaction between collagen and Endo180 and increase alpha-SMA expression.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
David Karasek, Jaromira Spurna, Dominika Macakova, Ondrej Krystynik, Veronika Kucerova
Summary: This study compared vascular damage indicators in different age groups of patients with type 2 diabetes (T2D) and determined their relationship to glycometabolic control. The results showed that older patients had higher arterial stiffness parameters, while markers of endothelial damage were unrelated to glycometabolic control. Age and systolic blood pressure were major determinants of arterial stiffness in T2D patients.
Article
Medicine, Research & Experimental
Florence Boissiere-Michot, Caroline Mollevi, Volker Baecker, Evelyne Crapez, William Jacot
Summary: Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) have been identified as prognostic and predictive biomarkers in breast cancer, but their clinical use is limited due to the need for fresh-frozen or fresh tumor samples for quantification. This study compared the expression levels of PLAU and SERPINE1 mRNA (corresponding to uPA and PAI-1 proteins) using in situ hybridization with immunometric assay in breast tumor samples. The results showed that in situ hybridization cannot replace the immunometric assay for quantification of uPA and PAI-1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Iffat Ara Aziz, Asher Fawwad, Iftikhar Ahmed Siddiqui, Kahkashan Perveen, Ruqaya Nangrejo, Nazish Waris, Abdul Basit
Summary: The aim of this study was to investigate the relationship between type of diabetes and plasma fibrinogen and plasminogen activator inhibitor-1 levels. The results showed that diabetes patients had higher levels of fibrinogen and plasminogen activator inhibitor-1, which increased their risk of coronary artery disease.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Tae-Il Kim, Siyoung Cho, Hanyong Jin, Jeehyeon Bae, Chanhee Park, Youngmi Kim
Summary: In this study, new fluorescent probes were developed for the detection and enhanced visualization of urokinase-type plasminogen activator receptor (uPAR). These probes consist of a donor-pi-acceptor-based fluorophore conjugated with a uPAR-binding AE105 peptide. Upon specific binding to uPAR, a turn-on fluorescence signal is instantly triggered, restricting the rotational deactivation of the fluorophore. The probes were successfully applied for the imaging of uPAR overexpressed on cancer cell membranes and in a cell-based uPAR inhibitor assay.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Hematology
Charles J. Lenz, Robert D. McBane, Kevin P. Cohoon, Dawid T. Janczak, Benjamin S. Simmons, Rayya A. Saadiq, Malgorzata Mimier, Ana I. Casanegra, Paul R. Daniels, Waldemar E. Wysokinski
EUROPEAN JOURNAL OF HAEMATOLOGY
(2018)
Article
Hematology
Waldemar E. Wysokinski, Kevin P. Cohoon, Ewa A. Konik, Rowlens M. Melduni, Naser M. Ammash, Samuel J. Asirvatham, Robert D. McBane
EUROPEAN JOURNAL OF HAEMATOLOGY
(2017)
Article
Hematology
Waldemar E. Wysokinski, Alfonso Tafur, Naser Ammash, Samuel J. Asirvatham, Yanhong Wu, Izabella Gosk-Bierska, Diane E. Grill, Joshua P. Slusser, Jozef Mruk, Robert D. McBane
EUROPEAN JOURNAL OF HAEMATOLOGY
(2017)
Article
Dermatology
Brian J. King, Rokea A. el-Azhary, Marian T. McEvoy, Raymond C. Shields, Robert D. McBane, James T. McCarthy, Mark D. P. Davis
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2017)
Review
Cardiac & Cardiovascular Systems
Michel T. Corban, Ali Duarte-Garcia, Robert D. McBane, Eric L. Matteson, Lilach O. Lerman, Amir Lerman
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2017)
Review
Radiology, Nuclear Medicine & Medical Imaging
Matthew Pieper, John Schmitz, Robert McBane, John Knudsen, Brendan McMenomy, Paul Wennberg, Thomas Atwell
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2017)
Editorial Material
Medicine, General & Internal
Robert D. McBane
MAYO CLINIC PROCEEDINGS
(2017)
Article
Obstetrics & Gynecology
Charles J. Lenz, Waldemar E. Wysokinski, Stanislav Henkin, Kevin P. Cohoon, Ana Casanegra, Benjamin S. Simmons, Rayya A. Saadiq, Paul R. Daniels, Ewa M. Wysokinska, Haraldur Bjarnason, Robert D. McBane
OBSTETRICS AND GYNECOLOGY
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sailen G. Naidu, Christine O. Menias, Rahmi Oklu, Robert S. Hines, Kinan Alhalabi, Gerges Makar, Fadi E. Shamoun, Stanislav Henkin, Robert D. McBane
AMERICAN JOURNAL OF ROENTGENOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Waldemar E. Wysokinski, Alfonso Tafur, Yanhong Wu, Naser Ammash, Samuel J. Asirvatham, Izabela Gosk-Bierska, Diane E. Grill, Joshua P. Slusser, Jozef Mruk, Robert D. McBane
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2018)
Article
Surgery
Melanie C. Bois, Michael D. Eckhardt, Vincent M. Cracolici, Matthew J. Loe, Joseph J. Ocel, William D. Edwards, Robert D. McBane, Thomas C. Bower, Joseph J. Maleszewski
JOURNAL OF VASCULAR SURGERY
(2018)
Article
Medicine, General & Internal
Dawid T. Janczak, Malgorzata K. Mimier, Robert D. McBane, Patrick S. Kamath, Benjamin S. Simmons, Dalene M. Bott-Kitslaar, Charles J. Lenz, Emily R. Vargas, David O. Hodge, Waldemar E. Wysokinski
MAYO CLINIC PROCEEDINGS
(2018)
Article
Surgery
Young Erben, Haraldur Bjarnason, Gudrun L. Oladottir, Robert D. McBane, Peter Gloviczki
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2018)
Article
Cardiac & Cardiovascular Systems
Andrew S. Tseng, J. William Schleifer, Win-Kuang Shen, Robert McBane, Sunil Mankad, Heidi Esser, Darko Vucicevic, Fadi E. Shamoun
CLINICAL CARDIOLOGY
(2017)
Review
Hematology
Ana I. Casanegra, Robert D. McBane, Haraldur Bjarnason
BRITISH JOURNAL OF HAEMATOLOGY
(2017)
Editorial Material
Cardiac & Cardiovascular Systems
Jose E. Exaire, Timothy A. Mixon
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Giuseppe Di Gioia, Federica Coletti, Lorenzo Buzzelli, Viviana Maestrini, Sara Monosilio, Andrea Segreti, Maria Rosaria Squeo, Erika Lemme, Antonio Nenna, Antonio Pelliccia
Summary: Dyslipidemia is common in Paralympic athletes, with lipid levels influenced by the type of disability and sporting discipline.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Esra Donmez, Sevgi Ozcan, Irfan Sahin, Murat Ziyrek, Ertugrul Okuyan
Summary: This study aimed to evaluate the predictive value of the GRACE risk score in acute pulmonary embolism (PE) patients for 30-day mortality and the need for thrombolytic treatment. The study found that the GRACE risk score, along with the PESI score, were independent risk factors associated with 30-day mortality and the need for thrombolytic treatment. The GRACE risk score showed high sensitivity and specificity in predicting mortality, and its combination with the PESI score helped define high-risk PE patients and predict poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Reza Reyaldeen, Kevser Akyuz, Zoran B. Popovic, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai
Summary: Transthoracic echocardiography (TTE) is commonly used to evaluate isolated tricuspid regurgitation (TR), but there is limited research comparing its quantification with magnetic resonance imaging (MRI). In this study, a novel TTE algorithm was developed to identify severe TR based on TTE parameters. The algorithm had a higher accuracy than the current guidelines' criteria in detecting severe TR by MRI.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Richard E. Casazza, Hymie Chera, Carlos Adolfo Rodriguez, Sergey Ayzenberg
Summary: This article presents a case of a patient with known situs inversus who underwent cardiac catheterization and was found to have chronic total occlusion in the right coronary artery. Situs inversus is a rare congenital abnormality characterized by the inverted position of chest and abdominal organs. Cardiac catheterization is uncommon in patients with this particular abnormality, highlighting the importance of customizing techniques to engage coronary arteries and optimize guide support for percutaneous coronary intervention if needed.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Georgiana Pintea Bentea, Brahim Berdaoui, Sophie Samyn, Marielle Morissens, Philippe van de Borne, Jose Castro Rodriguez
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Bulbul Ahmed, Melissa G. Farb, Shakun Karki, Sophia D'Alessandro, Niloo M. Edwards, Noyan Gokce
Summary: This study evaluated the angiogenic capacity of adipose tissue in patients undergoing cardiac surgeries and found that patients with coronary artery disease (CAD) had reduced angiogenic capacity in their pericardial adipose tissue. Gene expression analysis revealed upregulated expression of the anti-angiogenic gene TSP-1 in CAD patients, with no significant differences in other angiogenic factors. Additionally, inhibiting TSP-1 expression significantly improved angiogenic deficiency in CAD patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moshe Rav-Acha, Orli Wube, Oholi Tovia Brodie, Yoav Michowitz, Michael Ilan, Tal Ovdat, Robert Klempfner, Mahmud Suleiman, Ilan Goldenberg, Michael Glikson
Summary: The current guidelines recommend prophylactic implantable cardioverter-defibrillator (ICD) for patients with symptomatic heart failure (HF) and low left ventricular ejection fraction. However, not all patients will benefit from ICD treatment. This study evaluated the feasibility of using the MADIT-II-based Risk Stratification Score (MRSS) to predict the survival benefit of prophylactic ICDs in patients with HF. The results showed that different risk subgroups had varying levels of ICD survival benefit.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ariel Banai, Rachel Retsky, Lior Lupu, Erez Levi, David Zahler, Omri Feder, Roei Merin, Yan Topilsky, Raphael Rosso, Shmuel Banai, Sami Viskin, Ehud Chorin
Summary: This study aims to evaluate the association between electromechanical window (EMW) and ventricular tachyarrhythmias in patients with Takotsubo syndrome (TTS). The study found that TTS patients had a lower EMW value, which was associated with an increased risk of ventricular tachyarrhythmias.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Harun Kundi, Kobina Hagan, Tamer Yahya, Garima Sharma, Sadeer Al-Kindi, Zulqarnain Javed, Khurram Nasir
Summary: Using latent class analysis (LCA), the study identified clinical, demographic, and social subphenotypes in ASCVD population and assessed the risk of all-cause and cardiovascular mortality across different socioclinical classes. The results showed that the younger, female, non-Hispanic Black or Hispanic individuals with a high burden of co-morbidities and unfavorable social determinants of health had the highest risk of mortality in the identified latent classes.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moises A. Vasquez, Mina Iskander, Mohammed Mustafa, Juan A. Quintero-Martinez, Antonio Luna, Joel Mintz, Jose Noy, Juan Uribe, Ivan Mijares, Eduardo de Marchena, Yiannis S. Chatzizisis
Summary: The benefits of pericardiocentesis (PC) in patients with pulmonary hypertension (PH) and pericardial effusions are unclear. The study found that PC in PH patients is associated with higher in-hospital mortality and rates of cardiovascular complications.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ken Kuwajima, Mana Ogawa, Irving Ruiz, Hiroko Hasegawa, Nobuichiro Yagi, Florian Rader, Robert J. Siegel, Takahiro Shiota
Summary: After cardiac surgery, the longitudinal function of the right ventricle and left ventricle is reduced, despite preserved global functions. In particular, tricuspid annular plane systolic excursion (TAPSE) remains decreased after surgery.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Min -Jung Kim, Robert H. Aseltine Jr, Sara R. Tabtabai
Summary: This study evaluated the rates and causes of 30-day readmissions after discharge for heart failure (HF) as a primary and secondary diagnosis. The findings indicate that efforts to reduce readmission rates should include patients with secondary HF diagnosis, and surveillance should extend to 2 weeks postdischarge to identify at-risk patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ya He, Jianzhong Zhou
Summary: This study aimed to examine the relation between reverse septal curvature (RSC) and nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). The study found that patients with RSC were younger and had a higher incidence of NSVT, and RSC was identified as a strong independent risk factor for NSVT.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)