P16 INK4a Deletion Ameliorated Renal Tubulointerstitial Injury in a Stress-induced Premature Senescence Model of Bmi-1 Deficiency

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Doppler Parameters in Renal Transplant Dysfunction

(2017) Jing Gao et al.   JOURNAL OF ULTRASOUND IN MEDICINE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion

(2016) Aharon Helman et al.   NATURE MEDICINE

1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via Sirt1 in synoviocytes

(2016) Xin Gu et al.   Cell Death & Disease

ANG Promotes Proliferation and Invasion of the Cell of Lung Squamous Carcinoma by Directly Up-Regulating HMGA2

(2016) Li Xu et al.   Journal of Cancer

Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging

(2016) Ioannis Grammatikakis et al.   Aging-US

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

Annexin A2 silencing enhances apoptosis of human umbilical vein endothelial cells in vitro

(2015) Shu-Le Jiang et al.   Asian Pacific Journal of Tropical Medicine

Anti-aging Effect of Transplanted Amniotic Membrane Mesenchymal Stem Cells in a Premature Aging Model of Bmi-1 Deficiency

(2015) Chunfeng Xie et al.   Scientific Reports

Bmi-1 plays a critical role in protection from renal tubulointerstitial injury by maintaining redox balance

(2014) Jianliang Jin et al.   AGING CELL

Aging Research—Where Do We Stand and Where Are We Going?

(2014) Leonard Guarente   CELL

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Effects of berberine and red yeast on proinflammatory cytokines IL-6 and TNF-α in peripheral blood mononuclear cells (PBMCs) of human subjects

(2014) Carmen Spatuzza et al.   Frontiers in Pharmacology

Focused Ultrasound-Modulated Glomerular Ultrafiltration Assessed by Functional Changes in Renal Arteries

(2013) Feng-Yi Yang et al.   PLoS One

JBP485 improves gentamicin-induced acute renal failure by regulating the expression and function of Oat1 and Oat3 in rats

(2013) Xinjin Guo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Dual Inhibiting Senescence and Epithelial-to-Mesenchymal Transition by Erythropoietin Preserve Tubular Epithelial Cell Regeneration and Ameliorate Renal Fibrosis in Unilateral Ureteral Obstruction

(2013) Adis Tasanarong et al.   Biomed Research International

New Insights on Molecular Mechanisms of Renal Aging

(2012) R. Schmitt et al.   AMERICAN JOURNAL OF TRANSPLANTATION

TGF-β signaling in tissue fibrosis: Redox controls, target genes and therapeutic opportunities

(2012) Rohan Samarakoon et al.   CELLULAR SIGNALLING

Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases

(2012) R M Naylor et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

NF-κB inhibition delays DNA damage–induced senescence and aging in mice

(2012) Jeremy S. Tilstra et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular Senescence Limits Regenerative Capacity and Allograft Survival

(2012) H. Braun et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Bmi-1 Absence Causes Premature Brain Degeneration

(2012) Guangliang Cao et al.   PLoS One

Reactive oxygen species and hematopoietic stem cell senescence

(2011) Lijian Shao et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Tubulointerstitial injury and the progression of chronic kidney disease

(2011) Kavita S. Hodgkins et al.   PEDIATRIC NEPHROLOGY

An Improved Transplantation Strategy for Mouse Mesenchymal Stem Cells in an Acute Myocardial Infarction Model

(2011) Jianliang Jin et al.   PLoS One

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Senescent cells as a source of inflammatory factors for tumor progression

(2010) Albert R. Davalos et al.   CANCER AND METASTASIS REVIEWS

Performance of the Cockcroft-Gault, MDRD, and New CKD-EPI Formulas in Relation to GFR, Age, and Body Size

(2010) W. M. Michels et al.   Clinical Journal of the American Society of Nephrology

Bmi-1 extends the life span of normal human oral keratinocytes by inhibiting the TGF-β signaling

(2010) Reuben H. Kim et al.   EXPERIMENTAL CELL RESEARCH

Cell Senescence in the Aging Kidney

(2010) H. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

Epithelial–Mesenchymal Transition: From Molecular Mechanisms, Redox Regulation to Implications in Human Health and Disease

(2009) Stefania Cannito et al.   ANTIOXIDANTS & REDOX SIGNALING

Thr435phosphorylation regulates RelA (p65) NF-κB subunit transactivation

(2009) John M. O'Shea et al.   BIOCHEMICAL JOURNAL

Defects in mesenchymal stem cell self-renewal and cell fate determination lead to an osteopenic phenotype in Bmi-1 null mice

(2009) Heng-Wei Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bmi1 regulates mitochondrial function and the DNA damage response pathway

(2009) Jie Liu et al.   NATURE

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia

(2008) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA