Engineering a pH responsive pore forming protein

Semisynthetic Nanoreactor for Reversible Single-Molecule Covalent Chemistry

(2016) Joongoo Lee et al.   ACS Nano

Glasslike Membrane Protein Diffusion in a Crowded Membrane

(2016) Ignacio Munguira et al.   ACS Nano

Assemblies of pore-forming toxins visualized by atomic force microscopy

(2016) Neval Yilmaz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Trastuzumab-targeted gene delivery to Her2-overexpressing breast cancer cells

(2016) K Mann et al.   CANCER GENE THERAPY

Engineered transmembrane pores

(2016) Mariam Ayub et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Real-time, portable genome sequencing for Ebola surveillance

(2016) Joshua Quick et al.   NATURE

High-speed atomic force microscopy shows that annexin V stabilizes membranes on the second timescale

(2016) Atsushi Miyagi et al.   Nature Nanotechnology

Listeriolysin O Membrane Damaging Activity Involves Arc Formation and Lineaction -- Implication for Listeria monocytogenes Escape from Phagocytic Vacuole

(2016) Yi Ruan et al.   PLoS Pathogens

Nucleobase Recognition by Truncated α-Hemolysin Pores

(2015) Mariam Ayub et al.   ACS Nano

The Unique Molecular Choreography of Giant Pore Formation by the Cholesterol-Dependent Cytolysins of Gram-Positive Bacteria

(2015) Rodney K. Tweten et al.   Annual Review of Microbiology

Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation

(2015) Nicolas Chiaruttini et al.   CELL

The evolution and epidemiology of Listeria monocytogenes in Europe and the United States

(2015) Sara Lomonaco et al.   INFECTION GENETICS AND EVOLUTION

The ImageJ ecosystem: An open platform for biomedical image analysis

(2015) Johannes Schindelin et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Plasticity of Listeriolysin O Pores and its Regulation by pH and Unique Histidine

(2015) Marjetka Podobnik et al.   Scientific Reports

Engineering pH responsive fibronectin domains for biomedical applications

(2015) Pete Heinzelman et al.   Journal of Biological Engineering

Listeriolysin O Affects the Permeability of Caco-2 Monolayer in a Pore-Dependent and Ca2+-Independent Manner

(2015) Miša Mojca Cajnko et al.   PLoS One

Engineering color variants of green fluorescent protein (GFP) for thermostability, pH-sensitivity, and improved folding kinetics

(2014) Naser Aliye et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Construction of pH-sensitive Her2-binding IgG1-Fc by directed evolution

(2014) Michael W. Traxlmayr et al.   Biotechnology Journal

Filming Biomolecular Processes by High-Speed Atomic Force Microscopy

(2014) Toshio Ando et al.   CHEMICAL REVIEWS

pH-dependent Binding Engineering Reveals an FcRn Affinity Threshold That Governs IgG Recycling

(2014) M. Jack Borrok et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread

(2014) Mark A. Czuczman et al.   NATURE

Membrane pore formation at protein–lipid interfaces

(2014) Robert J.C. Gilbert et al.   TRENDS IN BIOCHEMICAL SCIENCES

Engineering allostery

(2014) Srivatsan Raman et al.   TRENDS IN GENETICS

Crystal structure of listeriolysin O reveals molecular details of oligomerization and pore formation

(2014) Stefan Köster et al.   Nature Communications

A New Model for Pore Formation by Cholesterol-Dependent Cytolysins

(2014) Cyril F. Reboul et al.   PLoS Computational Biology

Channel-Forming Bacterial Toxins in Biosensing and Macromolecule Delivery

(2014) Philip Gurnev et al.   Toxins

Detection of 3′-End RNA Uridylation with a Protein Nanopore

(2013) Massimiliano Clamer et al.   ACS Nano

Structure-based histidine substitution for optimizing pH-sensitive Staphylococcus protein A

(2013) Hideki Watanabe et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Nanopore-Based Identification of Individual Nucleotides for Direct RNA Sequencing

(2013) Mariam Ayub et al.   NANO LETTERS

Illumination of the Spatial Order of Intracellular pH by Genetically Encoded pH-Sensitive Sensors

(2013) Mojca Benčina   SENSORS

Listeria monocytogenes-Derived Listeriolysin O Has Pathogen-Associated Molecular Pattern-Like Properties Independent of Its Hemolytic Ability

(2012) Anu Wallecha et al.   Clinical and Vaccine Immunology

Software for drift compensation, particle tracking and particle analysis of high-speed atomic force microscopy image series

(2012) Mohamed Husain et al.   JOURNAL OF MOLECULAR RECOGNITION

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

H++ 3.0: automating pK prediction and the preparation of biomolecular structures for atomistic molecular modeling and simulations

(2012) R. Anandakrishnan et al.   NUCLEIC ACIDS RESEARCH

Listeriolysin O: the Swiss army knife of Listeria

(2012) Mélanie Anne Hamon et al.   TRENDS IN MICROBIOLOGY

pH dependence of listeriolysin O aggregation and pore-forming ability

(2011) Andrej Bavdek et al.   FEBS Journal

A combinatorial histidine scanning library approach to engineer highly pH-dependent protein switches

(2011) Megan L. Murtaugh et al.   PROTEIN SCIENCE

The Pore-Forming Toxin Listeriolysin O Mediates a Novel Entry Pathway of L. monocytogenes into Human Hepatocytes

(2011) Stephen Vadia et al.   PLoS Pathogens

Human perforin permeabilizing activity, but not binding to lipid membranes, is affected by pH

(2010) Tilen Praper et al.   MOLECULAR IMMUNOLOGY

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles

(2008) Cheryl L. Birmingham et al.   NATURE

Atomic force microscopy of supported lipid bilayers

(2008) Marie-Paule Mingeot-Leclercq et al.   Nature Protocols

Disparate proteins use similar architectures to damage membranes

(2008) Gregor Anderluh et al.   TRENDS IN BIOCHEMICAL SCIENCES