Engineering pH responsive fibronectin domains for biomedical applications

A generic approach to engineer antibody pH-switches using combinatorial histidine scanning libraries and yeast display

(2014) Christian Schröter et al.   mAbs

N-terminal β-strand swapping in a consensus-derived alternative scaffold driven by stabilizing hydrophobic interactions

(2014) Jinquan Luo et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

C-terminal β-strand swapping in a consensus-derived fibronectin Type III scaffold

(2013) Alexey Teplyakov et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Increasing Serum Half-life and Extending Cholesterol Loweringin Vivoby Engineering Antibody with pH-sensitive Binding to PCSK9

(2012) Javier Chaparro-Riggers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Triepitopic Antibody Fusions Inhibit Cetuximab-Resistant BRAF and KRAS Mutant Tumors via EGFR Signal Repression

(2012) Jamie B. Spangler et al.   JOURNAL OF MOLECULAR BIOLOGY

Design of pH Sensitive Binding Proteins from the Hyperthermophilic Sso7d Scaffold

(2012) Nimish Gera et al.   PLoS One

Epidermal growth factor receptor downregulation by small heterodimeric binding proteins

(2011) Benjamin J. Hackel et al.   PROTEIN ENGINEERING DESIGN & SELECTION

A combinatorial histidine scanning library approach to engineer highly pH-dependent protein switches

(2011) Megan L. Murtaugh et al.   PROTEIN SCIENCE

Anti-tumor effect of CT-322 as an Adnectin inhibitor of vascular endothelial growth factor receptor-2

(2010) Roni Mamluk et al.   mAbs

Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization

(2010) Tomoyuki Igawa et al.   NATURE BIOTECHNOLOGY