Review
Immunology
Frank Kowalzik, Daniel Schreiner, Christian Jensen, Daniel Teschner, Stephan Gehring, Fred Zepp
Summary: Increases in global population and population density have led to the spread of emerging pathogens, making vaccines the most cost-effective means of prevention. Traditional methods of vaccine production are not sufficient to ensure global protection, highlighting the urgent need for new technologies. mRNA-based vaccines offer numerous advantages over conventional vaccines, including safety, ability to generate both humoral and cell-mediated immunity, well-tolerated by healthy individuals, cost-effectiveness, and rapid production.
Article
Multidisciplinary Sciences
Tanner J. Varrelman, Christopher H. Remien, Andrew J. Basinski, Shelley Gorman, Alec Redwood, Scott L. Nuismer
Summary: This study evaluates the effectiveness of using betaherpesviruses as transmissible vaccine vectors. The mathematical model developed and parameterized using data from mouse populations infected with murine cytomegalovirus (MCMV) shows rapid and effective control of pathogens with the introduction of the transmissible vaccine. However, the effectiveness may vary across reservoir populations and specific vector strains used for the vaccine.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Infectious Diseases
J. W. Uffen, J. J. Oosterheert, V. A. Schweitzer, K. Thursky, H. A. H. Kaasjager, M. B. Ekkelenkamp
Summary: Sepsis is a major global cause of morbidity and mortality, with early recognition and treatment being crucial for improved outcomes. Various interventions such as automated triage systems, sepsis teams, and clinical pathways have been developed to aid in early recognition and management of sepsis in the emergency department. However, the evidence supporting the effectiveness of these interventions is limited, and implementation can be complex and costly. Support from professionals and ongoing education are essential for successful implementation, and the lack of accurate tools for sepsis identification remains a challenge.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Review
Immunology
Emilia de Freitas Beirigo, Pablo Igor Ribeiro Franco, Jose Rodrigues do Carmo Neto, Rhanoica Oliveira Guerra, Thais Farnesi Soares de Assunca, Isabella de Oliveira Ferrato de Sousa, Malu Mateus Santos Obata, Wellington Francisco Rodrigues, Juliana Reis Machado, Marcos Vinicius da Silva
Summary: Infectious diseases are a major global health concern and RNA vaccines have shown great potential as an effective alternative for their treatment and prevention.
MICROBIAL PATHOGENESIS
(2023)
Review
Plant Sciences
Srividhya Venkataraman, Imran Khan, Peyman Habibi, Maria Le, Rory Lippert, Kathleen Hefferon
Summary: Plants have been explored as a platform for producing pharmaceutical proteins for over 20 years. This review article focuses on the expression and downstream purification processes for plant-made vaccines. The advantages of using plants for vaccine production, such as cost-effectiveness, ease of scaling up, and the ability to produce complex therapeutic proteins, are discussed.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Nanoscience & Nanotechnology
Yang Bo, Hua Wang
Summary: Infectious diseases caused by pathogen infection are a major cause of human death, and biomaterials-based vaccines provide a promising solution. Traditional vaccines have failed to control highly infective or deadly pathogens effectively, but biomaterials-based vaccines can synergize the function of antigens and adjuvants, troubleshoot delivery issues, and manipulate immune cells.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Pediatrics
Kia Hee Schultz Dungu, Stine Lund, Emma Louise Malchau Carlsen, Ulla Birgitte Hartling, Astrid Thaarup Matthesen, Kristina Traeholt Franck, Marianne Kragh Thomsen, Ulrik Stenz Justesen, Hans Linde Nielsen, Alex Christian Yde Nielsen, Tine Brink Henriksen, Ulrikka Nygaard
Summary: This nationwide population-based cohort study aimed to estimate the incidence of neonatal herpes simplex virus (HSV) infection and the number of neonates with suspected invasive bacterial infection (IBI) needed to treat with acyclovir. The results showed a higher incidence of neonatal HSV infection than in previous decades, but a high NNT with empiric acyclovir. Therefore, it is recommended not to treat all neonates suspected of IBI with empiric acyclovir, as current European guidelines suggest.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Review
Pediatrics
Jinyan Zhou, Lingli Mei, Shuohui Chen
Summary: This study found that chlorhexidine cleansing had no significant effect on neonatal sepsis, but was effective in reducing neonatal skin bacterial colonization. It also significantly reduced central line-associated bloodstream infection in neonates based on large-sample studies. Further research is needed to determine the optimal concentration and frequency of chlorhexidine cleansing.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Review
Obstetrics & Gynecology
E. Joubert, A. C. Kekeh, C. N. Amin
Summary: This article provides a literature review on the current status of COVID-19 vaccination for pregnant and lactating individuals, aiming to assist them and healthcare providers in making informed decisions.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Review
Microbiology
Yuying Tian, Zhuoya Deng, Penghui Yang
Summary: The development of vaccines has provided effective strategies for preventing and controlling infectious diseases. The emergence of mRNA vaccine technologies, particularly with the success of mRNA vaccines against SARS-CoV-2, has stimulated further research in this field. This review discusses the strategies and delivery systems used in mRNA vaccines, provides an overview of current clinical trials, and explores the underlying mechanisms and potential challenges of mRNA vaccines.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Alessandra Lochen, Roy M. Anderson
Summary: This review examines the potential contributions of dynamic transmission models and economic models to future research and immunisation policy regarding Streptococcus pneumoniae infection. The models reveal key uncertainties in the biology and epidemiology of pneumococcal infection, impacting the cost-effectiveness of PCV.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Review
Immunology
Hiroshi Kiyono, Yoshikazu Yuki, Rika Nakahashi-Ouchida, Kohtaro Fujihashi
Summary: The mucosal immune system in the oral and nasal cavities plays a crucial role in recognizing pathogens and initiating immune responses. Dental science has been a key driving force in studying mucosal immunity and developing mucosal vaccines for oral infectious diseases. Mucosal immunology and vaccines have now become significant entities in the discipline of immunology.
INTERNATIONAL IMMUNOLOGY
(2021)
Review
Veterinary Sciences
Yiyang Yao, Zhipeng Zhang, Zhangping Yang
Summary: As the global population grows, the demand for beef and dairy products increases, putting tremendous pressures and challenges on the cattle industry. Vaccination is an economical and effective method for preventing bovine infectious diseases, but there are fewer comprehensive reviews and the variable nature of these diseases can weaken or render existing vaccines ineffective. Therefore, improving overall awareness of bovine vaccines is crucial.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Pediatrics
Luisa K. Hallmaier-Wacker, Amelia Andrews, Olisaeloka Nsonwu, Alicia Demirjian, Russell J. Hope, Theresa Lamagni, Simon M. Collin
Summary: This systematic review confirms that low and middle income countries bear a larger burden of Gram negative infections compared to high income countries. The incidence of infant Gram-negative bacteraemia is higher in LMIC, with Escherichia coli, Klebsiella, and Pseudomonas spp being the common pathogens causing early-onset infant bacteraemia and infant meningitis worldwide. Implementation of preventive measures could reduce the high incidence of Gram-negative bacteraemia in LMIC.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Pediatrics
Luisa K. Hallmaier-Wacker, Amelia Andrews, Russell Hope, Alicia Demirjian, Theresa L. Lamagni, Simon M. Collin
Summary: The incidence of invasive bacterial infections caused by Gram-negative pathogens in infants has increased in England from 2011-2019, primarily driven by an increase in late-onset infections. Escherichia coli is the most common Gram-negative pathogen and accounts for 27.2% of the overall rise in Gram-negative infant disease incidence.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Editorial Material
Immunology
Natalie Katzmarski, Jorge Dominguez-Andres, Branko Cirovic, Georgios Renieris, Eleonora Ciarlo, Didier Le Roy, Konstantin Lepikhov, Kathrin Kattler, Gilles Gasparoni, Kristian Haendler, Heidi Theis, Marc Beyer, Jos W. M. van der Meer, Leo A. B. Joosten, Jorn Walter, Joachim L. Schultze, Thierry Roger, Evangelos J. Giamarellos-Bourboulis, Andreas Schlitzer, Mihai G. Netea
Article
Biology
Elodie Pronier, Aygun Imanci, Dorothee Selimoglu-Buet, Bouchra Badaoui, Raphael Itzykson, Thierry Roger, Chloe Jego, Audrey Naimo, Maela Francillette, Marie Breckler, Orianne Wagner-Ballon, Maria E. Figueroa, Marine Aglave, Daniel Gautheret, Francoise Porteu, Olivier A. Bernard, William Vainchenker, Francois Delhommeau, Eric Solary, Nathalie M. Droin
Summary: This study demonstrates that TET2 downregulation promotes the production of MIF, a chemokine associated with clonal TET2 downregulation in myeloid cells. Targeting MIF could be a potential therapeutic strategy for conditions associated with TET2 mutations.
COMMUNICATIONS BIOLOGY
(2022)
Article
Critical Care Medicine
Irene T. Schrijver, Eleni Karakike, Charlotte Theroude, Petra Baumgartner, Alexandre Harari, Evangelos J. Giamarellos-Bourboulis, Thierry Calandra, Thierry Roger
Summary: This is the first study to associate high levels of M-MDSCs with improved survival in sepsis patients.
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2022)
Editorial Material
Immunology
Irene T. Schrijver, Charlotte Theroude, Nikolaos Antonakos, Jean Regina, Didier Le Roy, Pierre-Alexandre Bart, Jean-Daniel Chiche, Matthieu Perreau, Giuseppe Pantaleo, Thierry Calandra, Thierry Roger
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Letter
Infectious Diseases
Matteo Bassetti, Valentina Zuccaro, Erika Asperges, Luigia Scudeller, Daniele Roberto Giacobbe
JOURNAL OF INFECTION
(2022)
Article
Microbiology
Olivia Munoz, Riddhima Banga, Rachel Schelling, Francesco Andrea Procopio, Andrea Mastrangelo, Pauline Nortier, Khalid Ohmiti, Jean Daraspe, Matthias Cavassini, Craig Fenwick, Laurent Perez, Matthieu Perreau
Summary: This study reveals an immunovirological mechanism by which HIV exploits PD-L1 to suppress Tfh-cell function.
Article
Microbiology
Craig Fenwick, Priscilla Turelli, Dongchun Ni, Laurent Perez, Kelvin Lau, Cecile Herate, Romain Marlin, Erica Lana, Celine Pellaton, Charlene Raclot, Line Esteves-Leuenberger, Jeremy Campos, Alex Farina, Flurin Fiscalini, Nathalie Dereuddre-Bosquet, Francis Relouzat, Rana Abdelnabi, Caroline S. Foo, Johan Neyts, Pieter Leyssen, Yves Levy, Florence Pojer, Henning Stahlberg, Roger LeGrand, Didier Trono, Giuseppe Pantaleo
Summary: A monoclonal antibody named P2G3 isolated from a previously infected vaccinated donor shows strong neutralizing activity against the SARS-CoV-2 Omicron variant and provides complete prophylactic or therapeutic protection when used alone or in combination with another antibody. The unique epitope of P2G3 may have important implications for combating the Omicron variant.
NATURE MICROBIOLOGY
(2022)
Correction
Immunology
Natalie Katzmarski, Jorge Dominguez-Andres, Branko Cirovic, Georgios Renieris, Eleonora Ciarlo, Didier Le Roy, Konstantin Lepikhov, Kathrin Kattler, Gilles Gasparoni, Kristian Haendler, Heidi Theis, Marc Beyer, Jos W. M. van der Meer, Leo A. B. Joosten, Joern Walter, Joachim L. Schultze, Thierry Roger, Evangelos J. Giamarellos-Bourboulis, Andreas Schlitzer, Mihai G. Netea
Article
Oncology
Marc Pfefferle, Irina L. Dubach, Raphael M. Buzzi, Elena Duerst, Nadja Schulthess-Lutz, Livio Baselgia, Kerstin Hansen, Larissa Imhof, Sandra Koernig, Didier Le Roy, Thierry Roger, Rok Humar, Dominik J. Schaer, Florence Vallelian
Summary: The study revealed that CD40 signaling in Clec4f(+) Kupffer cells triggers anti-CD40 antibody-induced liver toxicity. However, controlled erythrophagocytosis and the linked anti-inflammatory signaling by the endogenous metabolite heme can be exploited to reprogram liver macrophages and prevent necroinflammatory liver disease caused by high-dose administration of anti-CD40 antibodies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Clinical Neurology
Amandine Mathias, Vasiliki Pantazou, Sylvain Perriot, Mathieu Canales, Samuel Jones, Larise Oberholster, Michael Moulin, Craig Fenwick, Raphael Bernard-Valnet, Marie Theaudin, Caroline Pot, Renaud A. Du Pasquier
Summary: This study aims to investigate the impact of ocrelizumab (OCRE) on immune cell subsets in patients with multiple sclerosis (pwMS). The results showed that OCRE not only depletes B cells, but also reduces memory CD8(+) T cells, which may increase the risk of infections. Therefore, clinicians should pay special attention to the increased infection risk when switching pwMS from other disease-modifying therapies (DMTs) to OCRE.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Article
Immunology
Hakim Hocini, Aurelie Wiedemann, Fabiola Blengio, Cecile Lefebvre, Minerva Cervantes-Gonzalez, Emile Foucat, Pascaline Tisserand, Mathieu Surenaud, Severin Coleon, Melanie Prague, Lydia Guillaumat, Corinne Krief, Craig Fenwick, Cedric Laouenan, Lila Bouadma, Jade Ghosn, Giuseppe Pantaleo, Rodolphe Thiebaut, Yves Levy, Laurent Abel, Amal Abrous, Claire Andrejak, Francois Angoulvant, Delphine Bachelet, Marie Bartoli, Sylvie Behilill, Marine Beluze, Krishna Bhavsar, Anissa Chair, Charlotte Charpentier, Leo Chenard, Catherine Chirouze, Sandrine Couffin-cadiergues, Camille Couffignal, Nathalie D. E. Castro, Marie-Pierre Debray, Dominique Deplanque, Diane Descamps, Alpha Diallo, Fernanda Dias D. A. Silva, Celine Dorival, Xavier Duval, Philippine Eloy, Vincent Enouf, Helene Esperou, Marina Esposito-farese, Manuel Etienne, Aline-Marie Florence, Alexandre Gaymard, Tristan Gigante, Morgane Gilg, Francois Goehringer, Jeremie Guedj, Ikram Houas, Isabelle Hoffmann, Jean-Sebastien Hulot, Salma Jaafoura, Simon Jamard, Ouifiya Kafif, Antoine Khalil, Nadhem Lafhej, Samira Laribi, Minh Le, Quentin LE. Hingrat, Soizic LE. Mestre, Sophie Letrou, Bruno Lina, Guillaume Lingas, Denis Malvy, France Mentre, Hugo Mouquet, Nadege Neant, Christelle Paul, Aurelie Papadopoulos, Ventzislava Petrov-sanchez, Gilles Peytavin, Valentine Piquard, Olivier Picone, Manuel Rosa-calatrava, Benedicte Rossignol, Patrick Rossignol, Carine Roy, Marion Schneider, Coralie Tardivon, Jean-Francois Timsit, Sarah Tubiana, Sylvie Van Der Werf, Benoit Visseaux
Summary: This study investigated the immunological dysfunction underlying the persistence of symptoms in individuals after severe COVID-19 infection. The analysis of cytokines, cell phenotypes, antibodies, and gene expression profiles revealed persistent abnormalities even up to 6 months after hospital discharge, including high levels of activation markers, T-cell abnormalities, decreased antibodies, and upregulation of genes related to blood components. These findings suggest the need for extended clinical follow-up and preventive measures for patients.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Infectious Diseases
Benedict Fallet, Mathilde Foglierini, Raphael Porret, Ana Alcaraz-Serna, Christophe Sauvage, Raphael Jenelten, Teofila Caplanusi, Michel Gilliet, Laurent Perez, Craig Fenwick, Raphael Genolet, Alexandre Harari, Sara Bobisse, Raphael Gottardo, Giuseppe Pantaleo, Yannick D. Mueller
Summary: Intradermal skin test (IDT) with mRNA vaccines can be used to measure T cell response in immunocompromised patients who did not generate serological responses after vaccination. The study found that positive IDT reactions in immunocompromised patients were associated with B cell-depleting treatment, while negative reactions were observed in transplant recipients. This study provides a new method to monitor seronegative patients and elderly populations with waning immunity.
JOURNAL OF INFECTION
(2023)
Editorial Material
Immunology
Lokesh Sharma, Shaon Sengupta, Thierry Roger
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Microbiology
Francois Danion, Anne Coste, Coralie Le Hyaric, Clea Melenotte, Frederic Lamoth, Thierry Calandra, Dea Garcia-Hermoso, Vishukumar Aimanianda, Fanny Lanternier, Olivier Lortholary
Summary: Mucormycosis is a rare and life-threatening fungal infection caused by molds of the order Mucorales. It mainly affects the lungs, following the rhino-orbito-cerebral (ROC) areas and the skin. Risk factors for pulmonary mucormycosis (PM) include hematological malignancies and solid organ transplantation, while ROC infections are commonly associated with diabetes mellitus. The diagnosis of PM relies on CT scans, cultures, PCR tests, and histology, and treatment involves liposomal amphotericin B as the first-line therapy.
Article
Infectious Diseases
Craig Fenwick, Priscilla Turelli, Yoan Duhoo, Kelvin Lau, Cecile Herate, Romain Marlin, Myriam Lamrayah, Jeremy Campos, Line Esteves-Leuenberger, Alex Farina, Charlene Raclot, Vanessa Genet, Flurin Fiscalini, Julien Cesborn, Laurent Perez, Nathalie Dereuddre-Bosquet, Vanessa Contreras, Kyllian Lheureux, Francis Relouzat, Rana Abdelnabi, Pieter Leyssen, Yves Levy, Florence Pojer, Roger Le Grand, Didier Trono, Giuseppe Pantaleo
Summary: This study isolated a potent neutralizing antibody that can neutralize various variants of SARS-CoV-2 and potentially provide prophylactic protection for immunocompromised patients.
JOURNAL OF INFECTION
(2023)