Article
Nutrition & Dietetics
Boguslaw Habrat, Andrzej Silczuk, Anna Klimkiewicz
Summary: Manganese encephalopathy is a recognized disorder in occupational medicine, and there has been an increase in cases among intravenous users of homemade methcathinone. A survey conducted in Polish rehabilitation centers revealed that over 4% of individuals being treated displayed symptoms of manganese encephalopathy, with a lack of knowledge on the subject in more than 70% of surveyed institutions. There is an urgent need for personnel training and dissemination of information on this emerging issue.
Review
Biochemistry & Molecular Biology
Alexander N. Rodichkin, Tomas R. Guilarte
Summary: Clinical reports on childhood-onset manganese-induced dystonia-parkinsonism have provided valuable insights, but our understanding of the underlying neuropathophysiology remains limited. The availability of Slc39a14 knockout animal models offers a powerful platform for further research into the neurological effects of elevated manganese concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Junyan Huo, Gan Zhang, Wenjing Wang, Wen Cao, Mengxia Wan, Tao Huang, Dongsheng Fan, Yu Fu
Summary: In this study, the bidirectional causal relationship between migraine and white matter lesions was explored using a two-sample mendelian randomization method. The analysis of a recent large-scale genome-wide association study data did not provide evidence for causality between white matter lesions and migraine.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Don Gueu Park, Suk Yun Kang, Jin Yong Hong, Mun Kyung Sunwoo, Jung Han Yoon
Summary: In a study investigating determinants of motor severity in vascular parkinsonism (VaP), it was found that regional white matter intensity (WMH) burden and comorbidities such as periventricular hyperintensities (PVH) and diabetes were significantly associated with motor severity in patients with normal dopamine transporter (DAT) imaging. These results suggest that diabetes and white matter hyperintensities may play a significant role in the development of motor symptoms in VaP.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Susanne A. Schneider, Soaham Desai, Onanong Phokaewvarangkul, Elena Cecilia Rosca, Jirada Sringean, Pria Anand, Gary alvarez Bravo, Francisco Cardoso, Anna M. Cervantes-Arslanian, Harshad Chovatiya, David Crosiers, Femke Dijkstra, Conor Fearon, Francisco Grandas, Eric Guedj, Antonio Mendez-Guerrero, Muhammad Hassan, Joseph Jankovic, Anthony E. Lang, Karim Makhoul, Lorenzo Muccioli, Sarah A. O'Shea, Vahid Reza Ostovan, Javier Ricardo Perez-Sanchez, Ritesh Ramdhani, Victoria Ros-Castello, Christina Schulte, Priyank Shah, Lars Wojtecki, Pramod Kumar Pal
Summary: COVID-19-associated movement disorders usually occur around 12.6 days after symptom onset. Most patients recover without residual symptoms within weeks or months, while a small fraction may experience persistent movement disorders, which are associated with severe COVID-19 and the development of encephalopathy.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Mengfei Cai, Mina A. Jacob, Mark R. van Loenen, Mayra Bergkamp, Jose Marques, David G. Norris, Marco Duering, Anil M. Tuladhar, Frank-Erik De Leeuw
Summary: This study investigated the temporal dynamics of small vessel disease (SVD) and the impact of vascular risk factors and baseline SVD burden on its progression. The findings showed that SVD progresses significantly over time, but mild white matter hyperintensities (WMH) rarely progress to severe WMH. Older age, baseline SVD burden, and vascular risk factors were associated with faster WMH progression and incident lacunes.
Article
Neuroimaging
Corey J. Bolton, Omair A. Khan, Elizabeth E. Moore, Kimberly R. Pechman, L. Taylor Davis, Dandan Liu, Bennett A. Landman, Katherine A. Gifford, Timothy J. Hohman, Angela L. Jefferson
Summary: Functional independence is an important predictor of quality of life in aging. This study found that smaller baseline grey matter volumes, particularly in regions commonly affected by Alzheimer's disease, and greater baseline white matter hyperintensities were associated with faster functional decline over a mean 5-year follow-up. These effects were stronger in participants at increased risk of AD, particularly those who carried the APOE ε4 allele.
NEUROIMAGE-CLINICAL
(2023)
Article
Psychiatry
Anastasios Politis, Nikolaos Kokras, Michael Souvatzoglou, Kostas Siarkos, Panagiotis Toulas, Constantin Potagas, Theodoros Hatzipanagiotou, Georgios Limouris, Panagiotis Alexopoulos
Summary: Parkinsonian symptoms induced by antipsychotics in elderly patients require a comprehensive diagnostic workup for accurate detection of the cause. Research shows that some cases are drug-induced, while others are caused by diseases such as Parkinson's disease.
Article
Chemistry, Multidisciplinary
Weitao Yang, Cuijun Deng, Xiudong Shi, Yan Xu, Chenyu Dai, Hui Wang, Kexin Bian, Tianming Cui, Bingbo Zhang
Summary: This study presents a structural and molecular fusion MRI nanoprobe for differential diagnosis of benign and malignant tumors. The nanoprobe enables both structural and molecular imaging of tumors, and can catalyze chemodynamic therapy within the tumor. This innovative nanoprobe strategy allows for the diagnosis of tumors from both spatial and molecular perspectives in a single-step MRI imaging, with potential applications in precision intervention.
Letter
Clinical Neurology
Vasilios C. Constantinides, Christina Deligianni, Antonios Dimitrakopoulos, George P. Paraskevas, Elisabeth Kapaki
Summary: The lentiform fork sign is a rare MRI finding typically associated with metabolic acidosis, but can also occur in autoimmune disorders. This case report describes a 73-year-old female patient with systemic lupus erythematosus presenting with the lentiform fork sign, which resolved with treatment. Further research is needed to explore the association between the lentiform fork sign and autoimmune disorders in the absence of metabolic acidosis.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Fang Yi, Mengfei Cai, Mina A. Jacob, Jose Marques, David G. Norris, Marco Duering, Anil M. Tuladhar, Frank-Erik de Leeuw
Summary: This study investigated the spatial distribution pattern and MRI predictors of incident lacunes in relation to white matter hyperintensity (WMH) in sporadic small vessel disease. The results suggest that the different distribution patterns of lacunes in relation to WMH may imply distinct underlying mechanisms, possibly linked to the pathophysiology of WMH.
Article
Clinical Neurology
Sonja Holm-Yildiz, Thomas Krag, Nanna Witting, Britt Staevnsbo Pedersen, Tina Dysgaard, Louise Sloth, Jonas Pedersen, Rebecca Kjaer, Linda Kannuberg, Julia Dahlqvist, Josefine de Stricker Borch, Tuva Solheim, Freja Fornander, Anne-Sofie Eisum, John Vissing
Summary: This study found that HypoPP can be a progressive myopathy in both patients with and without attacks of paralysis. The study also found that fat replacement of muscles increased in these patients.
JOURNAL OF NEUROLOGY
(2023)
Article
Psychiatry
Mina A. Jacob, Mengfei Cai, Vera van de Donk, Mayra Bergkamp, Jose Marques, David G. Norris, Roy P. C. Kessels, Jurgen A. H. R. Claassen, Marco Duering, Anil M. Tuladhar, Frank-Erik de Leeuw
Summary: The study investigated the relationship between baseline severity and progression of cerebral small vessel disease (SVD) on MRI markers and incident dementia over a 14-year follow-up period. The results showed that both baseline SVD severity and SVD progression were independently associated with an increased risk of all-cause dementia. Slowing SVD progression may delay the onset of dementia.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Matteo Lucchini, Sara Bortolani, Mauro Monforte, Manuela Papacci, Enzo Ricci, Massimiliano Mirabella, Giorgio Tasca
Summary: BCIM is an inflammatory myopathy that predominantly affects neck and proximal upper limb muscles, with MRI showing greater involvement in upper girdle and neck muscles compared with lower limbs. Early and appropriate treatment can lead to partial clinical and radiologic improvement in most patients.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Neurosciences
Valentina Bordin, Ilaria Bertani, Irene Mattioli, Vaanathi Sundaresan, Paul McCarthy, Sana Suri, Eniko Zsoldos, Nicola Filippini, Abda Mahmood, Luca Melazzini, Maria Marcella Lagana, Giovanna Zamboni, Archana Singh-Manoux, Mika Kivimaki, Klaus P. Ebmeier, Giuseppe Baselli, Mark Jenkinson, Clare E. Mackay, Eugene P. Duff, Ludovica Griffanti
Summary: This study explores the harmonization of white matter hyperintensity (WMH) measures across two major studies of healthy elderly populations, using preprocessing strategies and multivariate regression to reduce dataset differences and provide highly calibrated results.
Article
Clinical Neurology
Mari Muldmaa, Niccolo Emanuele Mencacci, Alan Pittman, Liis Kadastik-Eerme, Katrin Sikk, Pille Taba, John Hardy, Sulev Koks
Summary: In Estonian Parkinson's disease patients, GBA variants are the most common genetic mutations identified, with an overall pathogenic variant frequency of 1.1%. The frequency of any GBA variant was significantly higher in PD patients compared to controls.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Clinical Neurology
T. J. von Oertzen, A. Macerollo, M. A. Leone, E. Beghi, M. Crean, S. Oztuk, C. Bassetti, A. Twardzik, D. Bereczki, G. Di Liberto, R. Helbok, C. Oreja- Guevara, A. Pisani, A. Sauerbier, J. Sellner, R. Soffietti, M. Zedde, E. Bianchi, B. Bodini, F. Cavallieri, L. Campiglio, L. F. Maia, A. Priori, M. Rakusa, P. Taba, E. Moro, T. M. Jenkins
Summary: This paper presents expert consensus statements by the European Academy of Neurology (EAN) to guide neurologists caring for patients with COVID-19, using a refined Delphi methodology. While general recommendations for preventing COVID-19 transmission had high levels of agreement and importance, opinions varied regarding statements related to therapy.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Obstetrics & Gynecology
Ragnheidur Valdimarsdottir, Anna-Karin Wikstrom, Theodora Kunovac Kallak, Evangelia Elenis, Ove Axelsson, Hubert Preissl, S. J. Kumari A. Ubhayasekera, Jonas Bergquist, Inger Sundstrom Poromaa
Summary: Women with PCOS have higher testosterone levels during pregnancy than women without PCOS. High maternal testosterone levels in early second trimester are associated with an increased risk of developing preeclampsia in women with PCOS.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Public, Environmental & Occupational Health
Oskar Karlsson, Joacim Rocklov, Alizee P. Lehoux, Jonas Bergquist, Anna Rutgersson, Martin J. Blunt, Linda S. Birnbaum
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Clinical Neurology
Valter Niemela, Anne-Marie Landtblom, Dag Nyholm, Maria Kneider, Radu Constantinescu, Martin Paucar, Per Svenningsson, Sandy Abujrais, Joachim Burman, Ganna Shevchenko, Jonas Bergquist, Jimmy Sundblom
Summary: Identifying molecular changes in Huntington's disease is crucial for therapy development. Mass-spectrometry analysis revealed differences in protein expression between HD patients and controls, with PENK levels potentially serving as a marker for the state of medium spiny neurons in HD.
MOVEMENT DISORDERS
(2021)
Article
Genetics & Heredity
Amir Fallahshahroudi, Martin Johnsson, Enrico Sorato, S. J. Kumari A. Ubhayasekera, Jonas Bergquist, Jordi Altimiras, Per Jensen
Summary: The genetic variation in TSHR between red junglefowl and domestic chicken is reflected in differences in abundance, gene expression levels, hormone levels, sexual maturity, and behavior.
Article
Medicine, General & Internal
Dominic Stanculescu, Lars Larsson, Jonas Bergquist
Summary: This study suggests that maladaptive mechanisms inhibiting recovery in some ICU patients may also be present in ME/CFS, involving the suppression of pituitary gland tropic hormone secretion and a vicious circle of inflammation, oxidative and nitrosative stress (O&NS), and low thyroid hormone function. Further investigation through collaborative research projects is recommended.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Maria Victoria Ruiz-Perez, Lourdes Sainero-Alcolado, Ganna Oliynyk, Isabell Matuschek, Nicola Balboni, S. J. Kumari A. Ubhayasekera, Marteinn Thor Snaebjornsson, Kamil Makowski, Kristina Aaltonen, Daniel Bexell, Dolors Serra, Roland Nilsson, Jonas Bergquist, Almut Schulze, Marie Arsenian-Henriksson
Summary: Metabolic pathways, especially lipid metabolism, are rewired in tumors to support their growth and adaptation to stressful environments. In neuroblastoma, inhibition of fatty acid synthesis led to increased neural differentiation and reduced tumor burden independently of MYCN-status, showing promise as a pharmacological intervention strategy.
Article
Oncology
Ariadna Lara Gutierrez, Julia Hedlund Lindberg, Ganna Shevchenko, Inger Gustavsson, Jonas Bergquist, Ulf Gyllensten, Stefan Enroth
Summary: Cervical cancer is the fourth most common cancer among women worldwide, and screening programs increase its detection rate and survivability. Molecular screening for the presence of HPV as an alternative to physical examinations offers cost-efficient solutions, and our study found that protein biomarkers can aid in the detection of cervical cancer pre-stages.
Article
Biochemistry & Molecular Biology
Henrik Hill, Andris Elksnis, Per Lundkvist, Kumari Ubhayasekera, Jonas Bergquist, Bryndis Birnir, Per-Ola Carlsson, Daniel Espes
Summary: Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter found in the central nervous system and immune cells. Research has shown that GABA has immune-modulatory and beta-cell stimulatory effects and could potentially be used to treat type 1 diabetes. However, a study measuring the levels of GABA in T1D patients found that the levels were unchanged compared to healthy controls, suggesting that GABA secretion from beta-cells has minimal impact on systemic levels. The study also found correlations between GABA levels and certain cytokines and GAD-autoantibodies, indicating potential alterations in local GABA levels within pancreatic islets.
Article
Biochemistry & Molecular Biology
Wei Hu, Yaorui Hu, Yao Pei, Rongrong Li, Fuyi Xu, Xiaodong Chi, Jia Mi, Jonas Bergquist, Lu Lu, Luping Zhang, Chunhua Yang
Summary: A study found that there were 46 differentially expressed proteins between cervical carcinoma (CC) and normal tissues, with Integrin beta 6, PPP1CB, TMPO, PTGES3, and DTX3L significantly upregulated in CC, while Desmin was significantly downregulated. Silencing DTX3L could suppress CC cell proliferation, migration, invasion, and tumorigenesis, and enhance cell apoptosis. Furthermore, DTX3L silencing inhibited the activity of the PI3K/AKT/mTOR signaling pathway. These findings suggest that DTX3L may regulate CC progression through the PI3K/AKT/mTOR signaling pathway and could serve as a potential biomarker and therapeutic target for CC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sofia Persson, Kumari A. Ubhayasekera, Jonas Bergquist, Sahruh Turkmen, Inger Sundstroem Poromaa, Evangelia Elenis
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women, and hyperandrogenism can cause psychological morbidity and impaired quality of life. This study aimed to investigate whether hyperandrogenism persists into midlife and its impact on quality of life.
Article
Food Science & Technology
Julio Cesar Espana Amortegui, Heidi Pekar, Mark Dennis Chico Retrato, Malin Persson, Bengt Karlson, Jonas Bergquist, Aida Zuberovic-Muratovic
Summary: A LC-MS/MS method was developed for the simultaneous identification and quantification of cyanotoxins in edible bivalves. The method successfully detected and resolved two previously detected cyanotoxin congeners separately. The method showed limitations for certain cyanotoxins but overall was specific and robust for the parameters investigated. The method was applied to analyze mussel and oyster samples collected along the Swedish coast, and the results can contribute to future regulatory monitoring for cyanotoxins to ensure seafood safety.
Article
Infectious Diseases
Anja Naas, Peng Li, Clas Ahlm, Elisabeth Aurelius, Josef D. Jarhult, Silvia Schliamser, Marie Studahl, Wenzhong Xiao, Jonas Bergquist, Gabriel Westman
Summary: This study investigated the temporal changes of the CSF proteome in patients with herpes simplex encephalitis (HSE) and its association with factors such as anti-NMDAR serostatus, corticosteroid treatment, brain MRI, and neurocognitive performance. The results showed that the composition and activation pathways of CSF proteins vary at different stages of the disease. Additionally, it was found that several proteins were less abundant in patients with anti-NMDAR seropositivity compared to seronegativity.
INFECTIOUS DISEASES
(2023)
Article
Chemistry, Analytical
Mark Dennis Chico Retrato, Siyuan Qiu, Anna Lundquist, Aida Zuberovic Muratovic, Farshid Mashayekhy Rad, S. J. Kumari A. Ubhayasekera, Jonas Bergquist
Summary: This study describes a simple and robust method for the identification and quantification of 22 fatty acids in TPN components using gas chromatography-mass spectrometry. The method was evaluated according to the guidelines from FDA, EMA, and ICH, and demonstrated good methodological performance. The developed method has potential applications for quality assurance and control of TPN products.
ANALYTICAL METHODS
(2023)