Towards the development of mechanism-based biomarkers to diagnose drug hypersensitivity

The dynamics of herpesvirus reactivations during and after severe drug eruptions: their relation to the clinical phenotype and therapeutic outcome

(2014) T. Ishida et al.   ALLERGY

Innate immune cells express IL-17A/F in acute generalized exanthematous pustulosis and generalized pustular psoriasis

(2014) M. Kakeda et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Severe flucloxacillin-induced acute generalized exanthematous pustulosis (AGEP), with toxic epidermal necrolysis (TEN)-like features: does overlap between AGEP and TEN exist? Clinical report and review of the literature

(2014) S. van Hattem et al.   BRITISH JOURNAL OF DERMATOLOGY

The complexity of miRNA-mediated repression

(2014) A Wilczynska et al.   CELL DEATH AND DIFFERENTIATION

Abacavir Forms Novel Cross-Linking Abacavir Protein Adducts in Patients

(2014) Xiaoli Meng et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Aminopenicillin-associated exanthem: lymphocyte transformation testing revisited

(2014) A. Trautmann et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Increased ratio of FoxP3+ regulatory T cells/CD3+ T cells in skin lesions in drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms

(2014) H. Morito et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

The importance of hapten–protein complex formation in the development of drug allergy

(2014) Lee Faulkner et al.   Current Opinion in Allergy and Clinical Immunology

MicroRNAs play a role in spontaneous recovery from acute liver failure

(2014) Katharina John et al.   HEPATOLOGY

Immuno-miRs: critical regulators of T-cell development, function and ageing

(2014) Bart-Jan Kroesen et al.   IMMUNOLOGY

Identification and consequences of miRNA–target interactions — beyond repression of gene expression

(2014) Jean Hausser et al.   NATURE REVIEWS GENETICS

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Study of Protein Haptenation by Amoxicillin Through the Use of a Biotinylated Antibiotic

(2014) Adriana Ariza et al.   PLoS One

A Pilot Study of Serum MicroRNAs Panel as Potential Biomarkers for Diagnosis of Nonalcoholic Fatty Liver Disease

(2014) Youwen Tan et al.   PLoS One

Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis

(2014) J. Ward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Potential of MicroRNAs in Personalized Medicine against Cancers

(2014) Anne Saumet et al.   Biomed Research International

Granulysin as a Marker for Early Diagnosis of the Stevens–Johnson Syndrome

(2013) Riichiro Abe et al.   ANNALS OF INTERNAL MEDICINE

T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms

(2013) Catherine C. Bell et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Identification of Danger Signals in Nevirapine-Induced Skin Rash

(2013) Xiaochu Zhang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine–Albumin Conjugate Formation in Patients

(2013) Xiaoli Meng et al.   CHEMICAL RESEARCH IN TOXICOLOGY

In vitrodrug causality assessment in Stevens-Johnson syndrome - alternatives for lymphocyte transformation test

(2013) G. Porebski et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity

(2013) Krzysztof Bryniarski et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Upregulation of miR-18a-5p contributes to epidermal necrolysis in severe drug eruptions

(2013) Asako Ichihara et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dendritic Cell-Derived Exosomes Need To Activate Both T and B Cells To Induce Antitumor Immunity

(2013) T. I. Naslund et al.   JOURNAL OF IMMUNOLOGY

HLA Haplotype Determines Hapten or p-i T Cell Reactivity to Flucloxacillin

(2013) N. Wuillemin et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-based discovery of barriers to dedifferentiation of fibroblasts to pluripotent stem cells

(2013) Robert L Judson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-Wide and Species-Wide In Silico Screening for Intragenic MicroRNAs in Human, Mouse and Chicken

(2013) Irena Godnic et al.   PLoS One

Intracellular Modulation, Extracellular Disposal and Serum Increase of MiR-150 Mark Lymphocyte Activation

(2013) Paola de Candia et al.   PLoS One

Dual Role of miR-21 in CD4+ T-Cells: Activation-Induced miR-21 Supports Survival of Memory T-Cells and Regulates CCR7 Expression in Naive T-Cells

(2013) Katarzyna Smigielska-Czepiel et al.   PLoS One

Sulfamethoxazole Induces a Switch Mechanism in T Cell Receptors Containing TCRVβ20-1, Altering pHLA Recognition

(2013) Stephan Watkins et al.   PLoS One

The origin, function, and diagnostic potential of extracellular microRNAs in human body fluids

(2013) Hongwei Liang et al.   Wiley Interdisciplinary Reviews-RNA

Allergic contact dermatitis induces upregulation of identical microRNAs in humans and mice

(2012) Marie T. Vennegaard et al.   CONTACT DERMATITIS

Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases

(2012) Shashi Bala et al.   HEPATOLOGY

Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury

(2012) Manal M. Monshi et al.   HEPATOLOGY

Possible role of TH17 cells in the pathogenesis of Stevens-Johnson syndrome and toxic epidermal necrolysis

(2012) Yuichi Teraki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver

(2012) Shu-hao Hsu et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis

(2012) Wei-Chih Tsai et al.   JOURNAL OF CLINICAL INVESTIGATION

15 kDa Granulysin Causes Differentiation of Monocytes to Dendritic Cells but Lacks Cytotoxic Activity

(2012) C. Clayberger et al.   JOURNAL OF IMMUNOLOGY

Protein haptenation by amoxicillin: High resolution mass spectrometry analysis and identification of target proteins in serum

(2012) Adriana Ariza et al.   Journal of Proteomics

Landscape of transcription in human cells

(2012) Sarah Djebali et al.   NATURE

Recovered Patients with Stevens–Johson Syndrome and Toxic Epidermal Necrolysis Maintain Long-Lived IFN-γ and sFasL Memory Response

(2012) Meng Fu et al.   PLoS One

Adverse Drug Reactions Causing Admission to a Paediatric Hospital

(2012) Ruairi M. Gallagher et al.   PLoS One

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire

(2012) D. A. Ostrov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating microRNAs as Biomarkers, Therapeutic Targets, and Signaling Molecules

(2012) Seena K. Ajit   SENSORS

Secreted microRNAs: a new form of intercellular communication

(2012) Xi Chen et al.   TRENDS IN CELL BIOLOGY

Modulating the Strength and Threshold of NOTCH Oncogenic Signals by mir-181a-1/b-1

(2012) Rita Fragoso et al.   PLoS Genetics

The danger theory: 20 years later

(2012) Thomas Pradeu et al.   Frontiers in Immunology

NKp46+ cells express granulysin in multiple cutaneous adverse drug reactions

(2011) C. Schlapbach et al.   ALLERGY

High-Mobility Group Box 1 Protein (HMGB1) as a Novel Diagnostic Tool for Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome

(2011) Saeko Nakajima   ARCHIVES OF DERMATOLOGY

Death ligand TRAIL, secreted by CD1a+ and CD14+ cells in blister fluids, is involved in killing keratinocytes in toxic epidermal necrolysis

(2011) Elisabeth de Araujo et al.   EXPERIMENTAL DERMATOLOGY

Circulating microRNAs as potential markers of human drug-induced liver injury

(2011) Philip J. Starkey Lewis et al.   HEPATOLOGY

Drug hypersensitivity: Pharmacogenetics and clinical syndromes

(2011) Elizabeth J. Phillips et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis

(2011) Ayman Elsheikh et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T cell–mediated acute localized exanthematous pustulosis caused by finasteride

(2011) Sandra Tresch et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

MicroRNA Regulation of Molecular Networks Mapped by Global MicroRNA, mRNA, and Protein Expression in Activated T Lymphocytes

(2011) Y. A. Grigoryev et al.   JOURNAL OF IMMUNOLOGY

Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients

(2011) X. Meng et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Rapid immunochromatographic test for serum granulysin is useful for the prediction of Stevens-Johnson syndrome and toxic epidermal necrolysis

(2011) Yasuyuki Fujita et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Open letter to UK Prime Minister David Cameron and Health Secretary Andrew Lansley on safety of medicines

(2011) Kathy Archibald et al.   LANCET

Toward the blood-borne miRNome of human diseases

(2011) Andreas Keller et al.   NATURE METHODS

Evolution of microRNA diversity and regulation in animals

(2011) Eugene Berezikov   NATURE REVIEWS GENETICS

HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans

(2011) Mark McCormack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expression of α-defensin 1-3 in T cells from severe cutaneous drug-induced hypersensitivity reactions

(2010) E. Morel et al.   ALLERGY

Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis

(2010) Nobuyoshi Kosaka et al.   CANCER SCIENCE

Cutaneous adverse drug reactions in a hospital-based Chinese population

(2010) H.-Y. Huang et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

CD94/NKG2C is a killer effector molecule in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis

(2010) Esther Morel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Stimulation of human T cells with sulfonamides and sulfonamide metabolites

(2010) J. Luis Castrejon et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Drug Antigenicity, Immunogenicity, and Costimulatory Signaling: Evidence for Formation of a Functional Antigen through Immune Cell Metabolism

(2010) A. Elsheikh et al.   JOURNAL OF IMMUNOLOGY

IL-17 Amplifies Human Contact Hypersensitivity by Licensing Hapten Nonspecific Th1 Cells to Kill Autologous Keratinocytes

(2010) D. Pennino et al.   JOURNAL OF IMMUNOLOGY

Increased circulating Th17 frequencies and serum IL-22 levels in patients with acute generalized exanthematous pustulosis

(2010) R Kabashima et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Circulating MicroRNAs: a novel class of biomarkers to diagnose and monitor human cancers

(2010) Ke Zen et al.   MEDICINAL RESEARCH REVIEWS

Posttranscriptional Regulation of MicroRNA Biogenesis in Animals

(2010) Haruhiko Siomi et al.   MOLECULAR CELL

Human activated CD4+ T lymphocytes increase IL-2 expression by downregulating microRNA-181c

(2010) Qian Xue et al.   MOLECULAR IMMUNOLOGY

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A Multiorgan Antiviral T Cell Response

(2010) D. Picard et al.   Science Translational Medicine

Drug-specificin vitrorelease of IL-2, IL-5, IL-13 and IFN-γ in patients with delayed-type drug hypersensitivity

(2009) P. Lochmatter et al.   ALLERGY

In vitro detection and characterization of drug hypersensitivity using flow cytometry

(2009) M. Martin et al.   ALLERGY

An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes

(2009) G. Curtale et al.   BLOOD

MicroRNA Control in the Immune System: Basic Principles

(2009) Changchun Xiao et al.   CELL

Multiple Adduction Reactions of Nitroso Sulfamethoxazole with Cysteinyl Residues of Peptides and Proteins: Implications for Hapten Formation

(2009) Hayley E. Callan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Metabolic and Chemical Origins of Cross-Reactive Immunological Reactions to Arylamine Benzenesulfonamides: T-Cell Responses to Hydroxylamine and Nitroso Derivatives

(2009) J. Luis Castrejon et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Human drug hepatotoxicity: a contemporary clinical perspective

(2009) David N Assis et al.   Expert Opinion on Drug Metabolism & Toxicology

Th17 cytokines and their emerging roles in inflammation and autoimmunity

(2009) Lynette A. Fouser et al.   IMMUNOLOGICAL REVIEWS

"Danger" Conditions Increase Sulfamethoxazole-Protein Adduct Formation in Human Antigen-Presenting Cells

(2009) S. N. Lavergne et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Incidence of adverse cutaneous drug reactions in a Mexican sample: an exploratory study on their association to tumour necrosis factor alpha TNF2 allele

(2009) Y Charli-Joseph et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Many roads to maturity: microRNA biogenesis pathways and their regulation

(2009) Julia Winter et al.   NATURE CELL BIOLOGY

TNF,LTA,HSPA1LandHLA-DRgene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole

(2009) Ana Alfirevic et al.   PHARMACOGENOMICS

Circulating microRNAs, potential biomarkers for drug-induced liver injury

(2009) K. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytokine and chemokine expression in the skin from patients with maculopapular exanthema to drugs

(2008) T. D. Fernandez et al.   ALLERGY

Exosomes – nanovesicles with possible roles in allergic inflammation

(2008) C. Admyre et al.   ALLERGY

No association between HLA-B and cutaneous reactions to sulphonamides in human immunodeficiency virus-infected patients

(2008) Z.G. Vitezica et al.   BRITISH JOURNAL OF DERMATOLOGY

Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

(2008) Xi Chen et al.   CELL RESEARCH

Increased soluble Fas ligand levels in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis preceding skin detachment

(2008) Junko Murata et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

(2008) Changchun Xiao et al.   NATURE IMMUNOLOGY

Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis

(2008) Wen-Hung Chung et al.   NATURE MEDICINE

Detection of microRNA Expression in Human Peripheral Blood Microvesicles

(2008) Melissa Piper Hunter et al.   PLoS One

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA