Functional xenobiotic metabolism and efflux transporters in trout hepatocyte spheroid cultures

Fluorometric assessment of acetaminophen-induced toxicity in rat hepatocyte spheroids seeded on micro-space cell culture plates

(2014) Seigo Sanoh et al.   TOXICOLOGY IN VITRO

ABC transporters in fish species: a review

(2014) Marta Ferreira et al.   Frontiers in Physiology

3D Organotypic Cultures of Human HepaRG Cells: A Tool for In Vitro Toxicity Studies

(2013) Patrina Gunness et al.   TOXICOLOGICAL SCIENCES

Expression of the 49 human ATP binding cassette (ABC) genes in pluripotent embryonic stem cells and in early- and late-stage multipotent mesenchymal stem cells

(2012) Romain Barbet et al.   CELL CYCLE

Mechanism of the ABC transporter ATPase domains: catalytic models and the biochemical and biophysical record

(2012) Peter M. Jones et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Organotypic liver culture models: Meeting current challenges in toxicity testing

(2012) Edward L. LeCluyse et al.   CRITICAL REVIEWS IN TOXICOLOGY

Towards a more representative in vitro method for fish ecotoxicology: morphological and biochemical characterisation of three-dimensional spheroidal hepatocytes

(2012) Matthew G. Baron et al.   ECOTOXICOLOGY

Three-Dimensional HepaRG Model As An Attractive Tool for Toxicity Testing

(2012) Sofia B. Leite et al.   TOXICOLOGICAL SCIENCES

In vitromodels of xenobiotic metabolism in trout for use in environmental bioaccumulation studies

(2012) Chibuzor Uchea et al.   XENOBIOTICA

Functional Significance of Genetic Polymorphisms in P-glycoprotein (MDR1, ABCB1) and Breast Cancer Resistance Protein (BCRP, ABCG2)

(2011) Ichiro Ieiri   Drug Metabolism and Pharmacokinetics

In vivo and in vitro liver and gill EROD activity in rainbow trout (Oncorhynchus mykiss) exposed to the beta-blocker propranolol

(2011) Abigail E. Bartram et al.   ENVIRONMENTAL TOXICOLOGY

Uptake from water, biotransformation, and biliary excretion of pharmaceuticals by rainbow trout

(2011) Marja Lahti et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Effects of the polycyclic ketone tonalide (AHTN) on some cell viability parameters and transcription of P450 and immunoregulatory genes in rainbow trout RTG-2 cells

(2011) Elisa Randelli et al.   TOXICOLOGY IN VITRO

Constitutive mRNA expression and protein activity levels of nine ABC efflux transporters in seven permanent cell lines derived from different tissues of rainbow trout (Oncorhynchus mykiss)

(2010) Stephan Fischer et al.   AQUATIC TOXICOLOGY

Expression Levels of Drug-Metabolizing Enzyme, Transporter, and Nuclear Receptor mRNAs in a Novel Three-Dimensional Culture System for Human Hepatocytes Using Micro-space Plates

(2010) Masuhiro Nishimura et al.   Drug Metabolism and Pharmacokinetics

Comparative Analysis of Gene Expression in Rat Liver Tissue and Monolayer- and Spheroid-Cultured Hepatocytes

(2009) Yusuke Sakai et al.   CELLS TISSUES ORGANS

Alkoxyresorufin O-dealkylase assay using a rat hepatocyte spheroid microarray

(2009) Yusuke Sakai et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Testing in the third dimension

(2009) Molly M. Stevens   Nature Nanotechnology

Human pharmaceuticals modulate P-gp1 (ABCB1) transport activity in the fish cell line PLHC-1

(2008) Daniel Caminada et al.   AQUATIC TOXICOLOGY

Cloning and molecular characterization of apical efflux transporters (ABCB1, ABCB11 and ABCC2) in rainbow trout (Oncorhynchus mykiss) hepatocytes

(2008) Roko Zaja et al.   AQUATIC TOXICOLOGY

The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME–Tox)

(2008) Gergely Szakács et al.   DRUG DISCOVERY TODAY

Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function

(2008) Colleen M. Brophy et al.   HEPATOLOGY

Cloning and mRNA expression analysis of an ABCG2 (BCRP) efflux transporter in rainbow trout (Oncorhynchus mykiss) liver and primary hepatocytes

(2008) Roko Žaja et al.   MARINE ENVIRONMENTAL RESEARCH

Development and characterization of P-glycoprotein 1 (Pgp1, ABCB1)-mediated doxorubicin-resistant PLHC-1 hepatoma fish cell line

(2007) Roko Zaja et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY