Article
Neurosciences
Vishaal Rajani, Ameet S. Sengar, Michael W. Salter
Summary: SFKs are crucial non-receptor tyrosine kinases in multiple signalling pathways, playing a key role in regulating NMDAR function and neuronal transduction pathways. Src and Fyn members of SFKs are essential for inducing plasticity at hippocampal synapses, while aberrant regulation of NMDARs by SFKs is implicated in diseases like schizophrenia and pain hypersensitivity. The targeting of SFK protein-protein interactions could be a potential therapeutic strategy for restoring glutamatergic dysregulation in CNS disease pathophysiology.
Review
Cell Biology
Xianzheng Zhang, Dan Mei, Lingling Zhang, Wei Wei
Summary: Autoimmune diseases encompass a spectrum of over 80 known disorders, with B cells playing a critical role in their development. Src family protein kinases (SFKs), including LYN, BLK, and Fyn, are important regulators in B lymphocytes, impacting the risk and progression of autoimmune disorders. Understanding the functions of these SFKs in autoimmune diseases could provide valuable insights for future therapeutic strategies.
Review
Cell Biology
Andra Fortner, Alexandra Chera, Antoanela Tanca, Octavian Bucur
Summary: C-terminal Src kinase (CSK) plays a crucial role in regulating critical cellular decisions, mainly through negative regulation of the SRC family of tyrosine kinases (SFKs) to promote apoptosis. Abnormal functioning of CSK and activation of SFKs are associated with diseases such as cancer, cardiovascular, and neurological disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Verena Korte, Guenther Gademann, Ahmed Gawish, Hans-Joachim Ochel
Summary: This study investigated the antiproliferative effects of simvastatin in combination with ionizing radiation on prostate cancer cells, and found that radiation had a stronger inhibitory effect compared to simvastatin alone. However, the combined application of both modalities had a synergistic effect. Simvastatin exerted its antiproliferative effects by inducing the elevation of HMG-CoA reductase levels.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Alan Alfano, Jin Xu, Xi Yang, Dhanraj Deshmukh, Yun Qiu
Summary: Tubulin is a vital component of the cytoskeleton and plays crucial roles in cellular signaling, maintenance, and division. Increased expression of TUBB3, a type of beta-tubulin primarily found in neural cells, is associated with taxane resistance and poor prognosis. Here, we discovered that TUBB3 is phosphorylated at Tyrosine 340 (Y340) by c-Src in prostate cancer cells. Phosphorylation at Y340 regulates TUBB3 protein stability and subcellular localization. Inhibition of SRC kinase activity affects spindle stability in mitotic cells due to the lack of TUBB3 Y340 phosphorylation. Understanding the posttranslational regulation of TUBB3 could serve as potential biomarkers for disease recurrence and treatment failure.
Review
Plant Sciences
Maria Camila Rodriguez Gallo, R. Glen Uhrig
Summary: This mini-review summarizes the current knowledge of plant-specific protein kinase families involved in alternative splicing (AS) regulation and compares them to their counterparts in animals. The extensive phosphorylation of splicing-related proteins in plants is highlighted, underscoring the importance of investigating the impact of AS on protein and post-translational modifications.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jianmei Hou, Elizabeth Nguyen, Minglyanna Surudoi, Michael J. Roy, Onisha Patel, Isabelle S. Lucet, Xiuquan Ma, Roger J. Daly
Summary: This article investigates the regulation and role of pseudokinase scaffolds PEAK1 and PEAK2 in cell signaling. The study finds that PEAK3, the third family member, also plays a crucial role in promoting cell proliferation, migration, and invasion by interacting with various proteins.
Article
Hematology
Michael H. Kramer, Qiang Zhang, Robert Sprung, Ryan B. Day, Petra Erdmann-Gilmore, Yang Li, Ziheng Xu, Nichole M. Helton, Daniel R. George, Yiling Mi, Peter Westervelt, Jacqueline E. Payton, Sai M. Ramakrishnan, Christopher A. Miller, Daniel C. Link, John F. DiPersio, Matthew J. Walter, R. Reid Townsend, Timothy J. Ley
Summary: This study revealed previously undescribed features of AML patients through proteomic and phosphoproteomic data, such as posttranscriptionally regulated proteins and abnormal phosphorylation sites. These findings provide insights into protein dysregulation in AML pathogenesis.
Article
Biochemistry & Molecular Biology
Deisy Perdomo, Jose Bubis
Summary: The study identified the presence of Src family tyrosine kinases in dark-adapted retinas but found that the purified kinase was unable to use transducin as a substrate. This suggests that the specific cellular role of this retinal Src family member remains unknown.
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
(2021)
Article
Otorhinolaryngology
Anh Thu Vu, Lara Akingunsade, Konstantin Hoffer, Cordula Petersen, Christian Stephan Betz, Kai Rothkamm, Thorsten Rieckmann, Lara Bussmann, Malte Kriegs
Summary: The study demonstrates the potential benefits of SFK inhibition in HNSCC, but highlights the challenges due to non-specific effects of different drugs.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Samia Mohammed, Achraf A. Shamseddine, Benjamin Newcomb, Ronald S. Chavez, Tyler D. Panzner, Allen H. Lee, Daniel Canals, Chioma M. Okeoma, Christopher J. Clarke, Yusuf A. Hannun
Summary: Sublethal doses of Doxorubicin induce increased migration and invasion in cancer cells, independent of EMT and cancer stem cell population. Activation of SFKs, including Fyn, Yes, and Src, partly in a p53 and ATR-dependent manner, mediates these effects. Inhibiting SFKs with Dasatinib offers a potential therapeutic strategy to mitigate local invasion.
BREAST CANCER RESEARCH
(2021)
Article
Cell Biology
Chen Wang, Jie Zeng, Li-Jie Li, Min Xue, Si-Li He
Summary: The study showed that Cdc25A regulates ferroptosis in cervical cancer cells by modulating the levels of PKM2 and ErbB2, affecting the response of cervical cancer cells to sorafenib treatment.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Mamatha Kakarla, Sathyavathi ChallaSivaKanaka, Mary F. Dufficy, Victoria Gil, Yana Filipovich, Renee Vickman, Susan E. Crawford, Simon W. Hayward, Omar E. Franco
Summary: The increase of EFNB ligands in CAF in the TME of PCa plays a crucial role in promoting tumor growth and modulating the tumor environment. Activation of EFNB by Src family kinases transforms normal fibroblasts into CAF that affect PCa progression by secreting factors that enhance tumor growth and invasion. Through stromal-epithelial interactions, CAF contribute significantly to the tumorigenicity of PCa cells.
Review
Veterinary Sciences
Tong Zhou, Mingshu Wang, Anchun Cheng, Qiao Yang, Bin Tian, Ying Wu, Renyong Jia, Shun Chen, Mafeng Liu, Xin-Xin Zhao, Xuming Ou, Sai Mao, Di Sun, Shaqiu Zhang, Dekang Zhu, Juan Huang, Qun Gao, Yanling Yu, Ling Zhang
Summary: This article mainly describes the viral protein kinases and their mechanisms of regulating viral protein function through phosphorylation. The study of post-translational modification of viral proteins is of great significance for understanding viral infection mechanisms and developing antiviral treatment.
VETERINARY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Nannan Li, Guoxin Lin, Hao Zhang, Jian Sun, Ming Gui, Yan Liu, Wei Li, Jishi Liu, Juan Tang
Summary: Src family kinases (SFKs) have been found to play a crucial role in acute kidney injury (AKI), making them potential therapeutic targets.
Review
Virology
Christiane Mbianda, Ashraf El-Meanawy, Andrey Sorokin
JOURNAL OF CLINICAL VIROLOGY
(2015)
Review
Urology & Nephrology
Matthias Barton, Andrey Sorokin
SEMINARS IN NEPHROLOGY
(2015)
Article
Cardiac & Cardiovascular Systems
Andreas M. Beyer, Natalya Zinkevich, Bradley Miller, Yanping Liu, April L. Wittenburg, Michael Mitchell, Ralph Galdieri, Andrey Sorokin, David D. Gutterman
BASIC RESEARCH IN CARDIOLOGY
(2017)
Review
Biochemistry & Molecular Biology
Andrey Sorokin
CURRENT MEDICINAL CHEMISTRY
(2016)
Article
Biochemistry & Molecular Biology
Allison Gartung, Jiawei Zhao, Simon Chen, Emilio Mottillo, Garrett C. VanHecke, Young-Hoon Ahn, Krishna Rao Maddipati, Andrey Sorokin, James Granneman, Menq-Jer Lee
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Medicine, Research & Experimental
Bradley Miller, Oleg Palygin, Victoriya A. Rufanova, Andrew Chong, Jozef Lazar, Howard J. Jacob, David Mattson, Richard J. Roman, Jan M. Williams, Allen W. Cowley, Aron M. Geurts, Alexander Staruschenko, John D. Imig, Andrey Sorokin
JOURNAL OF CLINICAL INVESTIGATION
(2016)
Article
Medicine, Research & Experimental
Oleg Palygin, Bradley Miller, Daria V. Ilatovskaya, Andrey Sorokin, Alexander Staruschenko
Review
Cell Biology
Anna Alexanian, Andrey Sorokin
PHYSIOLOGICAL GENOMICS
(2017)
Article
Endocrinology & Metabolism
Bradley S. Miller, Shoshana R. Blumenthal, Alexey Shalygin, Kevin D. Wright, Alexander Staruschenko, John D. Imig, Andrey Sorokin
Article
Urology & Nephrology
Tengis S. Pavlov, Vladislav Levchenko, Paul M. O'Connor, Daria V. Ilatovskaya, Oleg Palygin, Takefumi Mori, David L. Mattson, Andrey Sorokin, Julian H. Lombard, Allen W. Cowley, Alexander Staruschenko
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2013)
Article
Biochemistry & Molecular Biology
Chen Yang, Chen Chen, Andrey Sorokin
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2014)
Article
Cardiac & Cardiovascular Systems
William E. Hughes, Joe Hockenberry, Bradley Miller, Andrey Sorokin, Andreas M. Beyer
Summary: This study demonstrates that modulation of p66Shc signaling impairs cerebral artery myogenic tone in a low renin model of hypertension, but this effect depends on the genetic background as modulated p66Shc signaling in Sprague-Dawley rats does not impair cerebral artery myogenic tone.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bradley Miller, Kevin Regner, Andrey Sorokin
Summary: Renal ischemia-reperfusion injury is a major cause of acute kidney injury, and p66Shc adaptor protein plays an important role in this process. However, this study found that p66Shc expression or its signaling did not contribute to renal damage in a rat model.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Physiology
Kevin D. Wright, Alexander Staruschenko, Andrey Sorokin
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2018)