Article
Biochemistry & Molecular Biology
Xu He, Lingling Yang, Meiqiu Wang, Pei Zhang, Ren Wang, Daxi Ji, Chunlin Gao, Zhengkun Xia
Summary: This study found that reduced expression of GPX4 is associated with focal segmental glomerulosclerosis (FSGS) and targeting ferroptosis could be a promising therapeutic option for FSGS patients. Treatment with the ferroptosis inhibitor Fer1 reduced proteinuria, prevented glomerulosclerosis, and attenuated podocyte injury in an FSGS mouse model.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Urology & Nephrology
Sara Falcone, Thomas Nicol, Andrew Blease, Michael J. Randles, Elizabeth Angus, Anton Page, Frederick W. K. Tam, Charles D. Pusey, Rachel Lennon, Paul K. Potter
Summary: Nephrotic syndrome is a disease characterized by severe proteinuria, hypoalbuminaemia, edema, and hyperlipidaemia. Genetic studies have identified proteins that play important roles in the signaling of the slit diaphragm, regulation of actin cytoskeleton dynamics, and cell-matrix interactions in nephrotic syndrome. In this study, a novel missense mutation in the L4a domain of the LAMA5 gene was identified in mice, leading to the development of nephrotic syndrome with histological and ultrastructural changes similar to those seen in patients. The reduced levels of LAMA5 and alteration in the matrix composition suggest the involvement of LAMA5 in the progression of nephrotic syndrome. Additionally, the genetic background of the mice affected the disease progression, indicating the influence of genetic factors in kidney diseases. Overall, this novel model provides valuable insights into the pathogenic mechanisms and potential therapeutic targets for nephrotic syndrome.
KIDNEY INTERNATIONAL
(2022)
Review
Urology & Nephrology
Robert Bronstein, Jesse Pace, Yogesh Gowthaman, David J. Salant, Sandeep K. Mallipattu
Summary: Podocytes and parietal epithelial cells (PECs) are principal cell types within the kidney glomerulus, with the former serving as a crucial part of the kidney filtration barrier and the latter representing a supporting epithelial layer. They share a developmental lineage and a conserved gene expression program. In addition to their homeostatic functions, podocytes and PECs also play roles in kidney pathogenesis, with PEC proliferation and migration being closely associated with podocyte loss in certain diseases.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Transplantation
Paola Romagnani, A. Richard Kitching, Nelson Leung, Hans-Joachim Anders
Summary: Glomerulonephritis (GN) is a diverse group of immune-mediated disorders, which cannot be properly classified or treated based on histological patterns alone. To overcome this problem, a new classification system is proposed that considers disease category, immunological activity, and chronicity, which will guide the therapeutic approach.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Medicine, General & Internal
Dominic Cosgrove, Jacob Madison
Summary: Alport syndrome is caused by variants in the COL4A3, COL4A4, or COL4A5 genes, resulting in glomerular pathology and other tissue abnormalities. Defects in the glomerular basement membrane lead to progressive glomerulosclerosis, requiring dialysis and kidney transplantation.
FRONTIERS IN MEDICINE
(2022)
Article
Cell Biology
Sweta Talyan, Samantha Filipow, Michael Ignarski, Magdalena Smieszek, He Chen, Lucas Kuehne, Linus Butt, Heike Gobel, K. Johanna R. Hoyer-Allo, Felix C. Koehler, Janine Altmuller, Paul Brinkkoeter, Bernhard Schermer, Thomas Benzing, Martin Kann, Roman-Ulrich Mueller, Christoph Dieterich
Summary: Diseases of the glomerulus are a common cause of chronic kidney disease, with FSGS being a classic example leading to proteinuria and scarring. Current lack of targeted treatments is due to limited understanding of podocyte defects. Emerging studies on lncRNAs in FSGS reveal a potential for new insights, with the bioinformatic pipeline CALINCA offering a solution for further exploration.
Article
Medicine, General & Internal
Hiddo J. L. Heerspink, Jai Radhakrishnan, Charles E. Alpers, Jonathan Barratt, Stewart Bieler, Ulysses Diva, Jula Inrig, Radko Komers, Alex Mercer, Irene L. Noronha, Michelle N. Rheault, William Rote, Brad Rovin, Howard Trachtman, Hernin Trimarchi, Muh Geot Wong, Vlado Perkovic
Summary: This study investigates the efficacy and safety of sparsentan, a novel medication, in adults with IgA nephropathy. The results demonstrate that sparsentan treatment significantly reduces proteinuria compared to irbesartan, with similar safety profiles. Further long-term studies are required to confirm the nephroprotective potential of sparsentan.
Article
Biochemistry & Molecular Biology
Supabhorn Yimthiang, David A. Vesey, Phisit Pouyfung, Tanaporn Khamphaya, Glenda C. Gobe, Soisungwan Satarug
Summary: Chronic cadmium exposure can cause kidney damage, leading to a decline in glomerular filtration rate (GFR) and tubular proteinuria. Diabetic kidney disease (DKD) is characterized by albuminuria and declining GFR, and exposure to cadmium can worsen the progression of kidney disease in diabetics. A study involving 88 diabetics and 88 controls found that even low levels of cadmium exposure were associated with tubular dysfunction and increased risk of albuminuria, especially in individuals with a higher body burden of cadmium, hypertension, and reduced eGFR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Urology & Nephrology
Lorena Schult, Rebecca Halbgebauer, Ebru Karasu, Markus Huber-Lang
Summary: Acute kidney injury is a common occurrence after trauma, burn, or sepsis and remains a challenging issue in the scientific and clinical field. While much is known about the effects on the renal tubular system, little is understood about the changes that occur within the glomerulus. This article aims to provide an overview of the immune response and inflammatory processes within the glomerulus during these critical illnesses, and identify potential targets for future research and treatment strategies.
JOURNAL OF NEPHROLOGY
(2023)
Article
Endocrinology & Metabolism
Bin Wang, Jing-Yi Qian, Tao-Tao Tang, Li-Lu Lin, Nan Yu, Hong-Lei Guo, Wei-Jie Ni, Ling-Li Lv, Yi Wen, Zuo-Lin Li, Min Wu, Jing-Yuan Cao, Bi-Cheng Liu
Summary: The study revealed that deficiency in the VDR/Atg3 axis leads to SD-TJ transition and foot process effacement in diabetic nephropathy by blocking the p62-mediated autophagy pathway.
Article
Physiology
Ramzi Khalil, Josephine D. D. Bonnemaijer, Reinhold Kreutz, Herman P. Spaink, Pancras C. W. Hogendoorn, Hans J. Baelde
Summary: Transmembrane protein 14A (TMEM14A) is an important protein involved in maintaining the integrity of the glomerular filtration barrier. It suppresses Bax-mediated apoptosis and its expression is increased in proteinuric renal diseases.
PHYSIOLOGICAL REPORTS
(2023)
Article
Cell Biology
Jan Boeckhaus, Lea Mohr, Hassan Dihazi, Burkhard Toenshoff, Lutz T. T. Weber, Lars Pape, Kay Latta, Henry Fehrenbach, Baerbel Lange-Sperandio, Matthias Kettwig, Hagen Staude, Sabine Koenig, Ulrike John-Kroegel, Jutta Gellermann, Bernd Hoppe, Matthias Galiano, Dieter Haffner, Heidrun Rhode, Oliver Gross
Summary: This study compares the urinary albumin-to-creatinine ratio (UACR) versus the urinary protein-to-creatinine ratio (UPCR) in early stages of chronic kidney disease (CKD), using Alport syndrome (AS) as a model disease. The findings suggest that measuring UACR and UPCR in spot urine is a reliable alternative to 24-hour urine collection in patients with normal glomerular filtration rate and low amounts of albuminuria.
Article
Medicine, Research & Experimental
Mohamed A. Saleh, Ahmed A. Shaaban, Iman M. Talaat, Atef Elmougy, Saryia F. Adra, Firdos Ahmad, Rizwan Qaisar, Adel B. Elmoselhi, Eman Abu-Gharbieh, Waseem El-Huneidi, Mohamed A. Eladl, George Shehatou, Hoda E. Kafl
Summary: This study investigated the potential role of ET-1 receptors in kidney diseases and found that ET-1 increases glomerular permeability and albuminuria by modulating the activity of the ETA-RhoA/ROCK-1/2 pathway. Selective ETA receptor blockade may represent a potential therapeutic strategy to limit glomerular injury and albuminuria.
Review
Cell Biology
Catherine Meyer-Schwesinger
Summary: The lysosome serves as a crucial regulatory platform in various vesicle trafficking pathways, enabling the degradation of a wide range of cargoes. Its central role in cell metabolism, immune response, inter-organelle and inter-cellular signaling, as well as membrane repair, has established the lysosome as a key component in cellular homeostasis.
CELL AND TISSUE RESEARCH
(2021)
Review
Medicine, General & Internal
Noorain Ahmad, Harish Veerapalli, Chetan Reddy Lankala, Everardo E. Castaneda, Afia Aziz, Amy G. Rockferry, Pousette Hamid
Summary: This systematic review found that endothelin receptor antagonists in combination with renin-angiotensin-aldosterone system inhibitors effectively reduce albuminuria and prevent the progression of diabetic kidney disease. However, more extensive clinical trials are still needed to confirm these relationships.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Virology
Christiane Mbianda, Ashraf El-Meanawy, Andrey Sorokin
JOURNAL OF CLINICAL VIROLOGY
(2015)
Article
Cardiac & Cardiovascular Systems
Andreas M. Beyer, Natalya Zinkevich, Bradley Miller, Yanping Liu, April L. Wittenburg, Michael Mitchell, Ralph Galdieri, Andrey Sorokin, David D. Gutterman
BASIC RESEARCH IN CARDIOLOGY
(2017)
Review
Biochemistry & Molecular Biology
Andrey Sorokin
CURRENT MEDICINAL CHEMISTRY
(2016)
Article
Biochemistry & Molecular Biology
Allison Gartung, Jiawei Zhao, Simon Chen, Emilio Mottillo, Garrett C. VanHecke, Young-Hoon Ahn, Krishna Rao Maddipati, Andrey Sorokin, James Granneman, Menq-Jer Lee
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Medicine, Research & Experimental
Bradley Miller, Oleg Palygin, Victoriya A. Rufanova, Andrew Chong, Jozef Lazar, Howard J. Jacob, David Mattson, Richard J. Roman, Jan M. Williams, Allen W. Cowley, Aron M. Geurts, Alexander Staruschenko, John D. Imig, Andrey Sorokin
JOURNAL OF CLINICAL INVESTIGATION
(2016)
Article
Medicine, Research & Experimental
Oleg Palygin, Bradley Miller, Daria V. Ilatovskaya, Andrey Sorokin, Alexander Staruschenko
Review
Cell Biology
Anna Alexanian, Andrey Sorokin
PHYSIOLOGICAL GENOMICS
(2017)
Article
Endocrinology & Metabolism
Bradley S. Miller, Shoshana R. Blumenthal, Alexey Shalygin, Kevin D. Wright, Alexander Staruschenko, John D. Imig, Andrey Sorokin
Article
Urology & Nephrology
Tengis S. Pavlov, Vladislav Levchenko, Paul M. O'Connor, Daria V. Ilatovskaya, Oleg Palygin, Takefumi Mori, David L. Mattson, Andrey Sorokin, Julian H. Lombard, Allen W. Cowley, Alexander Staruschenko
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2013)
Article
Biochemistry & Molecular Biology
Chen Yang, Chen Chen, Andrey Sorokin
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2014)
Article
Oncology
Anna Alexanian, Bradley Miller, Marla Chesnik, Shama Mirza, Andrey Sorokin
Article
Cardiac & Cardiovascular Systems
William E. Hughes, Joe Hockenberry, Bradley Miller, Andrey Sorokin, Andreas M. Beyer
Summary: This study demonstrates that modulation of p66Shc signaling impairs cerebral artery myogenic tone in a low renin model of hypertension, but this effect depends on the genetic background as modulated p66Shc signaling in Sprague-Dawley rats does not impair cerebral artery myogenic tone.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bradley Miller, Kevin Regner, Andrey Sorokin
Summary: Renal ischemia-reperfusion injury is a major cause of acute kidney injury, and p66Shc adaptor protein plays an important role in this process. However, this study found that p66Shc expression or its signaling did not contribute to renal damage in a rat model.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Physiology
Kevin D. Wright, Alexander Staruschenko, Andrey Sorokin
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2018)