Src and Fyn regulation of NMDA receptors in health and disease

Neurotransmitter‐gated ion channels, still front and centre stage

(2021) Derek Bowie   JOURNAL OF PHYSIOLOGY-LONDON

Fyn‐mediated phosphorylation of Pyk2 promotes its activation and dissociation downstream of gonadotropin‐releasing hormone receptor

(2020) Sayomi Higa‐Nakamine et al.   FEBS Journal

Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions

(2020) Carmela Matrone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Architecture and function of NMDA receptors: an evolutionary perspective

(2020) David Stroebel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Src Family Kinases in the Central Nervous System：Their Emerging Role in Pathophysiology of Migraine and Neuropathic Pain

(2020) Lingdi Nie et al.   Current Neuropharmacology

Leptin modulates pancreatic β-cell membrane potential through Src kinase-mediated phosphorylation of NMDA receptors

(2020) Veronica A. Cochrane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Strangers in strange lands: mitochondrial proteins found at extra-mitochondrial locations

(2019) David P. Scanlon et al.   BIOCHEMICAL JOURNAL

Src deficient mice demonstrate behavioral and electrophysiological alterations relevant to psychiatric and developmental disease

(2019) Katelyn R. Ward et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons

(2019) Pedro Afonso et al.   Science Signaling

MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome–nascent chain complex

(2019) Cong Wang et al.   EMBO REPORTS

Leptin Controls Glutamatergic Synaptogenesis and NMDA-Receptor Trafficking via Fyn Kinase Regulation of NR2B

(2019) Tyler Bland et al.   ENDOCRINOLOGY

An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors

(2017) David P. Scanlon et al.   Nature Communications

Dopamine promotes NMDA receptor hypofunction in the retina through D1 receptor-mediated Csk activation, Src inhibition and decrease of GluN2B phosphorylation

(2017) Renato Socodato et al.   Scientific Reports

Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing

(2016) Michael E. Hildebrand et al.   Cell Reports

Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder

(2016) M Föcking et al.   Translational Psychiatry

Fyn Kinase regulates GluN2B subunit-dominant NMDA receptors in human induced pluripotent stem cell-derived neurons

(2016) Wen-Bo Zhang et al.   Scientific Reports

STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit

(2016) Meng Tian et al.   Scientific Reports

Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors

(2015) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Src kinase as a mediator of convergent molecular abnormalities leading to NMDAR hypoactivity in schizophrenia

(2014) A Banerjee et al.   MOLECULAR PSYCHIATRY

Architecture of mammalian respiratory complex I

(2014) Kutti R. Vinothkumar et al.   NATURE

Crystal structure of a heterotetrameric NMDA receptor ion channel

(2014) E. Karakas et al.   SCIENCE

Group II metabotropic glutamate receptors modify N-methyl-D-aspartate receptors via Src kinase

(2013) Catherine Trepanier et al.   Scientific Reports

Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial

(2012) Michael D Hill et al.   LANCET NEUROLOGY

Loss of Function Studies in Mice and Genetic Association Link Receptor Protein Tyrosine Phosphatase α to Schizophrenia

(2011) Nagahide Takahashi et al.   BIOLOGICAL PSYCHIATRY

Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases

(2011) Kai Yang et al.   EMBO JOURNAL

Dysregulated Src upregulation of NMDA receptor activity: a common link in chronic pain and schizophrenia

(2011) Michael W. Salter et al.   FEBS Journal

Schizophrenia susceptibility pathway neuregulin 1–ErbB4 suppresses Src upregulation of NMDA receptors

(2011) Graham M Pitcher et al.   NATURE MEDICINE

Synaptic Dysbindin-1 Reductions in Schizophrenia Occur in an Isoform-Specific Manner Indicating Their Subsynaptic Location

(2011) Konrad Talbot et al.   PLoS One

Src family kinases: modulators of neurotransmitter receptor function and behavior

(2011) Hiroshi Ohnishi et al.   TRENDS IN NEUROSCIENCES

Impairment of CaMKII activation and attenuation of neuropathic pain in mice lacking NR2B phosphorylated at Tyr1472

(2010) Shinji Matsumura et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression

(2009) J. Tang et al.   HUMAN MOLECULAR GENETICS

ErbB4 is a suppressor of long-term potentiation in the adult hippocampus

(2009) Graham M. Pitcher et al.   NEUROREPORT

Control of Excitatory Synaptic Transmission by C-terminal Src Kinase

(2008) Jindong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex

(2008) Xue Jun Liu et al.   NATURE MEDICINE