Integrated Akt/PKB Signaling in Immunomodulation and Its Potential Role in Cancer Immunotherapy
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Title
Integrated Akt/PKB Signaling in Immunomodulation and Its Potential Role in Cancer Immunotherapy
Authors
Keywords
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Journal
JNCI-Journal of the National Cancer Institute
Volume 107, Issue 7, Pages djv171-djv171
Publisher
Oxford University Press (OUP)
Online
2015-06-13
DOI
10.1093/jnci/djv171
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Note: Only part of the references are listed.- Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy
- (2014) A. B. van der Waart et al. BLOOD
- MicroRNA-150 inhibits tumor invasion and metastasis by targeting the chemokine receptor CCR6, in advanced cutaneous T-cell lymphoma
- (2014) M. Ito et al. BLOOD
- Akt Inhibition Enhances Expansion of Potent Tumor-Specific Lymphocytes with Memory Cell Characteristics
- (2014) J. G. Crompton et al. CANCER RESEARCH
- Improving chemoradiation efficacy by PI3-K/AKT inhibition
- (2014) Hanneke Stegeman et al. CANCER TREATMENT REVIEWS
- Phase II Study of Perifosine and Sorafenib Dual-Targeted Therapy in Patients with Relapsed or Refractory Lymphoproliferative Diseases
- (2014) A. Guidetti et al. CLINICAL CANCER RESEARCH
- Interrogating Two Schedules of the AKT Inhibitor MK-2206 in Patients with Advanced Solid Tumors Incorporating Novel Pharmacodynamic and Functional Imaging Biomarkers
- (2014) T. A. Yap et al. CLINICAL CANCER RESEARCH
- Effects of MAPK and PI3K Pathways on PD-L1 Expression in Melanoma
- (2014) M. Atefi et al. CLINICAL CANCER RESEARCH
- Tumor-Associated Macrophages: From Mechanisms to Therapy
- (2014) Roy Noy et al. IMMUNITY
- FOXO1 Transcription Factor: A Critical Effector of the PI3K-AKT Axis in B-Cell Development
- (2014) Maciej Szydłowski et al. INTERNATIONAL REVIEWS OF IMMUNOLOGY
- Fibroblast heterogeneity in the cancer wound
- (2014) Daniel Öhlund et al. JOURNAL OF EXPERIMENTAL MEDICINE
- CCR6 Regulates the Migration of Inflammatory and Regulatory T Cells
- (2014) T. Yamazaki et al. JOURNAL OF IMMUNOLOGY
- Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways
- (2014) S. R. Jacobs et al. JOURNAL OF IMMUNOLOGY
- PI3K/Akt regulates survival during differentiation of human macrophages by maintaining NF-κB-dependent expression of antiapoptotic Bcl-xL
- (2014) Aurelia Busca et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
- (2014) Roy S. Herbst et al. NATURE
- The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis
- (2014) Sandra S. McAllister et al. NATURE CELL BIOLOGY
- PI3K and cancer: lessons, challenges and opportunities
- (2014) David A. Fruman et al. NATURE REVIEWS DRUG DISCOVERY
- Making new contacts: the mTOR network in metabolism and signalling crosstalk
- (2014) Mitsugu Shimobayashi et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Selective Inhibition of Regulatory T Cells by Targeting the PI3K-Akt Pathway
- (2014) R. Abu-Eid et al. Cancer Immunology Research
- PD-L1 Expression in Triple-Negative Breast Cancer
- (2014) E. A. Mittendorf et al. Cancer Immunology Research
- Proliferation-Independent Control of Tumor Glycolysis by PDGFR-Mediated AKT Activation
- (2013) C. Ran et al. CANCER RESEARCH
- Vemurafenib reverses immunosuppression by myeloid derived suppressor cells
- (2013) Bastian Schilling et al. INTERNATIONAL JOURNAL OF CANCER
- Host immunity contributes to the anti-melanoma activity of BRAF inhibitors
- (2013) Deborah A. Knight et al. JOURNAL OF CLINICAL INVESTIGATION
- PKB/Akt-Dependent Regulation of Cell Motility
- (2013) G. Xue et al. JNCI-Journal of the National Cancer Institute
- PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signaling
- (2013) M Conley-LaComb et al. Molecular Cancer
- Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch
- (2013) Patrick M Gubser et al. NATURE IMMUNOLOGY
- PTEN Loss Increases PD-L1 Protein Expression and Affects the Correlation between PD-L1 Expression and Clinical Parameters in Colorectal Cancer
- (2013) Minmin Song et al. PLoS One
- Novel Agents for Multiple Myeloma to Overcome Resistance in Phase III Clinical Trials
- (2013) Robert Z. Orlowski SEMINARS IN ONCOLOGY
- Signaling interplay between transforming growth factor-β receptor and PI3K/AKT pathways in cancer
- (2013) Long Zhang et al. TRENDS IN BIOCHEMICAL SCIENCES
- AEBP1 upregulation confers acquired resistance to BRAF (V600E) inhibition in melanoma
- (2013) W Hu et al. Cell Death & Disease
- PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function
- (2012) L. van de Laar et al. BLOOD
- HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCR -selected mouse thymocytes
- (2012) G. W. Wong et al. BLOOD
- TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma
- (2012) Pengyuan Yang et al. CANCER CELL
- Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
- (2012) Douglas Hanahan et al. CANCER CELL
- Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
- (2012) Patrick S. Ward et al. CANCER CELL
- Abstract 5204: PP2A- STAT3 pathway mediates suspension survival in colon cancer stem cells
- (2012) Chia Chien Chang et al. CANCER RESEARCH
- Abstract 3928: Inhibition of the ubiquitin proteasome system differentially regulates glucocorticoid receptor-mediated transcriptional processes
- (2012) Kimberly R. Wiggins et al. CANCER RESEARCH
- Molecular Pathways: Next-Generation Immunotherapy--Inhibiting Programmed Death-Ligand 1 and Programmed Death-1
- (2012) D. S. Chen et al. CLINICAL CANCER RESEARCH
- Transcription Factor Foxo1 Represses T-bet-Mediated Effector Functions and Promotes Memory CD8+ T Cell Differentiation
- (2012) Rajesh R. Rao et al. IMMUNITY
- Signal Integration by Akt Regulates CD8 T Cell Effector and Memory Differentiation
- (2012) E. H. Kim et al. JOURNAL OF IMMUNOLOGY
- Cancer-Associated Fibroblasts Drive the Progression of Metastasis through both Paracrine and Mechanical Pressure on Cancer Tissue
- (2012) G. S. Karagiannis et al. MOLECULAR CANCER RESEARCH
- Novel Foxo1-dependent transcriptional programs control Treg cell function
- (2012) Weiming Ouyang et al. NATURE
- Inflammation linking EMT and cancer stem cells
- (2012) Chenchen Zhou et al. ORAL ONCOLOGY
- Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization
- (2012) A. Arranz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Akt/PKB-Mediated Phosphorylation of Twist1 Promotes Tumor Metastasis via Mediating Cross-Talk between PI3K/Akt and TGF-β Signaling Axes
- (2012) Gongda Xue et al. Cancer Discovery
- PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ
- (2012) Yutaka Kurebayashi et al. Cell Reports
- FOXO3 Regulates CD8 T Cell Memory by T Cell-Intrinsic Mechanisms
- (2012) Jeremy A. Sullivan et al. PLoS Pathogens
- Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasis
- (2011) Shouye Wang et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Natural Innate and Adaptive Immunity to Cancer
- (2011) Matthew D. Vesely et al. Annual Review of Immunology
- Tumor-Associated Neutrophils: New Targets for Cancer Therapy
- (2011) A. D. Gregory et al. CANCER RESEARCH
- Selective BRAF Inhibitors Induce Marked T-cell Infiltration into Human Metastatic Melanoma
- (2011) James S. Wilmott et al. CLINICAL CANCER RESEARCH
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- (2011) Andrew N. Macintyre et al. IMMUNITY
- GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice
- (2011) Elizabeth A. Wohlfert et al. JOURNAL OF CLINICAL INVESTIGATION
- Perifosine Plus Bortezomib and Dexamethasone in Patients With Relapsed/Refractory Multiple Myeloma Previously Treated With Bortezomib: Results of a Multicenter Phase I/II Trial
- (2011) Paul G. Richardson et al. JOURNAL OF CLINICAL ONCOLOGY
- Randomized Placebo-Controlled Phase II Trial of Perifosine Plus Capecitabine As Second- or Third-Line Therapy in Patients With Metastatic Colorectal Cancer
- (2011) Johanna C. Bendell et al. JOURNAL OF CLINICAL ONCOLOGY
- First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors
- (2011) Timothy A. Yap et al. JOURNAL OF CLINICAL ONCOLOGY
- MHC Class II Engagement by Its Ligand LAG-3 (CD223) Contributes to Melanoma Resistance to Apoptosis
- (2011) P. Hemon et al. JOURNAL OF IMMUNOLOGY
- CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
- (2011) Bin-Zhi Qian et al. NATURE
- Crosstalk in NF-κB signaling pathways
- (2011) Andrea Oeckinghaus et al. NATURE IMMUNOLOGY
- Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
- (2011) Paul B. Chapman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells
- (2011) A. C. Benitez et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
- (2011) Q. Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus
- (2011) L. Calderon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion
- (2011) R. D. Schreiber et al. SCIENCE
- Akt isoforms differentially regulate neutrophil functions
- (2010) J. Chen et al. BLOOD
- NF-κB promotes epithelial–mesenchymal transition, migration and invasion of pancreatic carcinoma cells
- (2010) Harald J. Maier et al. CANCER LETTERS
- Macrophage Diversity Enhances Tumor Progression and Metastasis
- (2010) Bin-Zhi Qian et al. CELL
- Clinical and Translational Studies of a Phase II Trial of the Novel Oral Akt Inhibitor Perifosine in Relapsed or Relapsed/Refractory Waldenstrom's Macroglobulinemia
- (2010) I. M. Ghobrial et al. CLINICAL CANCER RESEARCH
- Akt inhibitors in clinical development for the treatment of cancer
- (2010) Sumanta Kumar Pal et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells
- (2010) Jörg Schrader et al. HEPATOLOGY
- Foxo Transcription Factors Control Regulatory T Cell Development and Function
- (2010) Yann M. Kerdiles et al. IMMUNITY
- Role of PI3K in the generation and survival of B cells
- (2010) Markus Werner et al. IMMUNOLOGICAL REVIEWS
- CD34 antigen: Determination of specific sites of phosphorylation in vitro and in vivo
- (2010) Leesa J. Deterding et al. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
- Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells
- (2010) Yohsuke Harada et al. JOURNAL OF EXPERIMENTAL MEDICINE
- PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors: Figure 1.
- (2010) Matthias Merkenschlager et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Human CD34-Derived Myeloid Dendritic Cell Development Requires Intact Phosphatidylinositol 3-Kinase-Protein Kinase B-Mammalian Target of Rapamycin Signaling
- (2010) L. van de Laar et al. JOURNAL OF IMMUNOLOGY
- Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells
- (2010) Weiming Ouyang et al. NATURE IMMUNOLOGY
- Foxo: in command of T lymphocyte homeostasis and tolerance
- (2010) Weiming Ouyang et al. TRENDS IN IMMUNOLOGY
- CCR7 and CCR9 together recruit hematopoietic progenitors to the adult thymus
- (2009) D. A. Zlotoff et al. BLOOD
- Akt1 and Akt2 promote peripheral B-cell maturation and survival
- (2009) M. Calamito et al. BLOOD
- Induction of granzyme B expression in T-cell receptor/CD28-stimulated human regulatory T cells is suppressed by inhibitors of the PI3K-mTOR pathway
- (2009) Olga V Efimova et al. BMC IMMUNOLOGY
- Cancer Metastasis Is Accelerated through Immunosuppression during Snail-Induced EMT of Cancer Cells
- (2009) Chie Kudo-Saito et al. CANCER CELL
- EphA2 Mediates Ligand-Dependent Inhibition and Ligand-Independent Promotion of Cell Migration and Invasion via a Reciprocal Regulatory Loop with Akt
- (2009) Hui Miao et al. CANCER CELL
- Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion
- (2009) Yadi Wu et al. CANCER CELL
- Lymphocytes in cancer development: Polarization towards pro-tumor immunity
- (2009) Brian Ruffell et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Leptin exerts an anti-apoptotic effect on human dendritic cells via the PI3K-Akt signaling pathway
- (2009) Benedetta Mattioli et al. FEBS LETTERS
- Akt-mediated regulation of NFκB and the essentialness of NFκB for the oncogenicity of PI3K and Akt
- (2009) Dong Bai et al. INTERNATIONAL JOURNAL OF CANCER
- The nuts and bolts of AGC protein kinases
- (2009) Laura R. Pearce et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- TOR complex 2: a signaling pathway of its own
- (2009) Nadine Cybulski et al. TRENDS IN BIOCHEMICAL SCIENCES
- PD-1 and Its Ligands in Tolerance and Immunity
- (2008) Mary E. Keir et al. Annual Review of Immunology
- Antagonizing dopamine D1-like receptor inhibits Th17 cell differentiation: Preventive and therapeutic effects on experimental autoimmune encephalomyelitis
- (2008) Kazuhisa Nakano et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Tumor Escape Mechanism Governed by Myeloid-Derived Suppressor Cells
- (2008) S. Nagaraj et al. CANCER RESEARCH
- Molecular regulation of T-cell anergy
- (2008) Yan Zheng et al. EMBO REPORTS
- Akt-dependent regulation of NF- B is controlled by mTOR and Raptor in association with IKK
- (2008) H. C. Dan et al. GENES & DEVELOPMENT
- CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer
- (2008) Yoshiki Mizukami et al. INTERNATIONAL JOURNAL OF CANCER
- Foxp3 Inhibits RORγt-mediatedIL-17AmRNA Transcription through Direct Interaction with RORγt
- (2008) Kenji Ichiyama et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells
- (2008) Sokol Haxhinasto et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Activation of Akt as a Mechanism for Tumor Immune Evasion
- (2008) Kyung Hee Noh et al. MOLECULAR THERAPY
- TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function
- (2008) Liang Zhou et al. NATURE
- Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin
- (2008) Tomoya Kitamura et al. NATURE CELL BIOLOGY
- PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer
- (2008) C A Crane et al. ONCOGENE
- T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
- (2008) S. Sauer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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