PKB/Akt-Dependent Regulation of Cell Motility

BMK1 Kinase Suppresses Epithelial-Mesenchymal Transition through the Akt/GSK3  Signaling Pathway

(2012) R. Chen et al.   CANCER RESEARCH

Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer

(2012) Karim Nacerddine et al.   JOURNAL OF CLINICAL INVESTIGATION

Effective guidance of collective migration based on differences in cell states

(2012) M. Inaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt/PKB-Mediated Phosphorylation of Twist1 Promotes Tumor Metastasis via Mediating Cross-Talk between PI3K/Akt and TGF-β Signaling Axes

(2012) Gongda Xue et al.   Cancer Discovery

Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2

(2011) Christel Boutonnet et al.   CELL CYCLE

A comparison between Skp2 and FOXO1 for their cytoplasmic localization by Akt1

(2011) Hongbo Wang et al.   CELL CYCLE

Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization

(2011) Tarig Bashir et al.   CELL CYCLE

Vimentin in cancer and its potential as a molecular target for cancer therapy

(2011) Arun Satelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The PI3K/Akt pathway mediates the expression of type I collagen induced by TGF-β2 in human retinal pigment epithelial cells

(2011) Katsuhiko Yokoyama et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway

(2011) Marco A. O. Magalhaes et al.   JOURNAL OF CELL BIOLOGY

Identification of RhoGAP22 as an Akt-Dependent Regulator of Cell Motility in Response to Insulin

(2011) A. F. Rowland et al.   MOLECULAR AND CELLULAR BIOLOGY

Akt2 interacts with Snail1 in the E-cadherin promoter

(2011) P Villagrasa et al.   ONCOGENE

Akt1 deficiency delays tumor progression, vascular invasion and distant metastasis in a murine model of thyroid cancer

(2011) M Saji et al.   ONCOGENE

Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion and metastasis

(2011) E K Kim et al.   ONCOGENE

Girdin maintains the stemness of glioblastoma stem cells

(2011) A Natsume et al.   ONCOGENE

Ptenb Mediates Gastrulation Cell Movements via Cdc42/AKT1 in Zebrafish

(2011) Chen-Min Yeh et al.   PLoS One

Intracellular pH gradients in migrating cells

(2010) Christine Martin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Control of Actin Filament Treadmilling in Cell Motility

(2010) Beáta Bugyi et al.   Annual Review of Biophysics

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

(2010) Sonja J. Heidorn et al.   CELL

Akt2 regulates expression of the actin-bundling protein palladin

(2010) Y. Rebecca Chin et al.   FEBS LETTERS

β-Actin is a downstream effector of the PI3K/AKT signaling pathway in myeloma cells

(2010) Yen-Peng Ho et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Actin-Bundling Protein Palladin Is an Akt1-Specific Substrate that Regulates Breast Cancer Cell Migration

(2010) Y. Rebecca Chin et al.   MOLECULAR CELL

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

(2010) Georgia Hatzivassiliou et al.   NATURE

Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition

(2010) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

Vimentin is a novel AKT1 target mediating motility and invasion

(2010) Q-S Zhu et al.   ONCOGENE

Differential roles of ERK and Akt pathways in regulation of EGFR-mediated signaling and motility in prostate cancer cells

(2010) Y Gan et al.   ONCOGENE

Vimentin Is a Novel Anti-Cancer Therapeutic Target; Insights from In Vitro and In Vivo Mice Xenograft Studies

(2010) Guy Lahat et al.   PLoS One

Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation

(2010) K. Ericson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altering PI3K-Akt signalling in zebrafish embryos affects PTEN phosphorylation and gastrulation

(2009) Ariel Finkielsztein et al.   BIOLOGY OF THE CELL

EphA2 Mediates Ligand-Dependent Inhibition and Ligand-Independent Promotion of Cell Migration and Invasion via a Reciprocal Regulatory Loop with Akt

(2009) Hui Miao et al.   CANCER CELL

Translational Activation of Snail1 and Other Developmentally Regulated Transcription Factors by YB-1 Promotes an Epithelial-Mesenchymal Transition

(2009) Valentina Evdokimova et al.   CANCER CELL

Akt1 and Akt2 Play Distinct Roles in the Initiation and Metastatic Phases of Mammary Tumor Progression

(2009) R. L. Dillon et al.   CANCER RESEARCH

Girding for migratory cues: roles of the Akt substrate Girdin in cancer progression and angiogenesis

(2009) Liang Weng et al.   CANCER SCIENCE

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Identification of novel cell migration-promoting genes by a functional genetic screen

(2009) Minchul Seo et al.   FASEB JOURNAL

The Sodium-Hydrogen Exchanger NHE1 Is an Akt Substrate Necessary for Actin Filament Reorganization by Growth Factors

(2009) Marcel E. Meima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasticity of cell migration: a multiscale tuning model

(2009) Peter Friedl et al.   JOURNAL OF CELL BIOLOGY

Inhibition of Akt activity induces the mesenchymal-to-epithelial reverting transition with restoring E-cadherin expression in KB and KOSCC-25B oral squamous cell carcinoma cells

(2009) Kyoung-Ok Hong et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

(2009) Daming Gao et al.   NATURE CELL BIOLOGY

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

(2009) Hui-Kuan Lin et al.   NATURE CELL BIOLOGY

Nitric oxide and TNF-  trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice

(2009) S. E. Erdman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs Differentially Regulated by Akt Isoforms Control EMT and Stem Cell Renewal in Cancer Cells

(2009) D. Iliopoulos et al.   Science Signaling

An Actin-Binding Protein Girdin Regulates the Motility of Breast Cancer Cells

(2008) P. Jiang et al.   CANCER RESEARCH

PDGF signalling controls the migration of mesoderm cells during chick gastrulation by regulating N-cadherin expression

(2008) X. Yang et al.   DEVELOPMENT

Integrin Trafficking Regulated by Rab21 Is Necessary for Cytokinesis

(2008) Teijo Pellinen et al.   DEVELOPMENTAL CELL

Integrin-linked kinase regulates E-cadherin expression through PARP-1

(2008) Timothy R. McPhee et al.   DEVELOPMENTAL DYNAMICS

Filamin A is a novel caveolin-1-dependent target in IGF-I-stimulated cancer cell migration

(2008) Dana Ravid et al.   EXPERIMENTAL CELL RESEARCH

Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation

(2008) J. Egea et al.   GENES & DEVELOPMENT

Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments

(2008) Patrick T. Caswell et al.   JOURNAL OF CELL BIOLOGY

Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K–Akt signaling

(2008) Naoto Kakinuma et al.   JOURNAL OF CELL BIOLOGY

Scaffolding function of PAK in the PDK1–Akt pathway

(2008) Maiko Higuchi et al.   NATURE CELL BIOLOGY

Membrane recognition by phospholipid-binding domains

(2008) Mark A. Lemmon   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Involvement of PI3K/Akt Pathway in TGF-β2-Mediated Epithelial Mesenchymal Transition in Human Lens Epithelial Cells

(2008) Ke Yao et al.   OPHTHALMIC RESEARCH

Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis

(2008) P. G. Rychahou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA