New trends in the use of aminoglycosides

Sequence-based design of bioactive small molecules that target precursor microRNAs

(2014) Sai Pradeep Velagapudi et al.   Nature Chemical Biology

A Random Sequential Mechanism of Aminoglycoside Acetylation by Mycobacterium tuberculosis Eis Protein

(2014) Oleg V. Tsodikov et al.   PLoS One

4′-O-substitutions determine selectivity of aminoglycoside antibiotics

(2014) Déborah Perez-Fernandez et al.   Nature Communications

Targeting the Production of Oncogenic MicroRNAs with Multimodal Synthetic Small Molecules

(2013) Duc Duy Vo et al.   ACS Chemical Biology

Synthetic Aminoglycosides Efficiently Suppress Cystic Fibrosis Transmembrane Conductance Regulator Nonsense Mutations and Are Enhanced by Ivacaftor

(2013) Xiaojiao Xue et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Redesign of Substrate Specificity and Identification of the Aminoglycoside Binding Residues of Eis from Mycobacterium tuberculosis

(2013) Benjamin C. Jennings et al.   BIOCHEMISTRY

Di-alkylated paromomycin derivatives: Targeting the membranes of Gram positive pathogens that cause skin infections

(2013) Yifat Berkov-Zrihen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Investigation of antibacterial mode of action for traditional and amphiphilic aminoglycosides

(2013) Venkatareddy Udumula et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Riboswitch Control of Aminoglycoside Antibiotic Resistance

(2013) Xu Jia et al.   CELL

Chemical and Structural Insights into the Regioversatility of the Aminoglycoside Acetyltransferase Eis

(2013) Jacob L. Houghton et al.   CHEMBIOCHEM

Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections

(2013) Kristin J Labby et al.   Future Medicinal Chemistry

Designer Aminoglycosides That Selectively Inhibit Cytoplasmic Rather than Mitochondrial Ribosomes Show Decreased Ototoxicity

(2013) Eli Shulman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and Evaluation of Hetero- and Homodimers of Ribosome-Targeting Antibiotics: Antimicrobial Activity, in Vitro Inhibition of Translation, and Drug Resistance

(2013) Yifat Berkov-Zrihen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tuning the Antibacterial Activity of Amphiphilic Neamine Derivatives and Comparison to Paromamine Homologues

(2013) Louis Zimmermann et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Role of Cytosolic Protein Synthesis Inhibition in Aminoglycoside Ototoxicity

(2013) S. P. Francis et al.   JOURNAL OF NEUROSCIENCE

Long-term nonsense suppression therapy moderates MPS I-H disease progression

(2013) Gwen Gunn et al.   MOLECULAR GENETICS AND METABOLISM

Topical Paromomycin with or without Gentamicin for Cutaneous Leishmaniasis

(2013) Afif Ben Salah et al.   NEW ENGLAND JOURNAL OF MEDICINE

Site-Selective Displacement of Tobramycin Hydroxyls for Preparation of Antimicrobial Cationic Amphiphiles

(2013) Yifat Berkov-Zrihen et al.   ORGANIC LETTERS

Membrane Lipid-Modulated Mechanism of Action and Non-Cytotoxicity of Novel Fungicide Aminoglycoside FG08

(2013) Sanjib Shrestha et al.   PLoS One

Identification of the molecular attributes required for aminoglycoside activity against Leishmania

(2013) M. Shalev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Impact of Aminoglycosides on the Dynamics of Translation Elongation

(2013) Albert Tsai et al.   Cell Reports

Rational Design of Bioactive, Modularly Assembled Aminoglycosides Targeting the RNA that Causes Myotonic Dystrophy Type 1

(2012) Jessica L. Childs-Disney et al.   ACS Chemical Biology

Aminoglycoside Antibiotics in the 21st Century

(2012) Bernd Becker et al.   ACS Chemical Biology

6′′-Thioether Tobramycin Analogues: Towards Selective Targeting of Bacterial Membranes

(2012) Ido M. Herzog et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In VitroSusceptibility of Pythium insidiosum Isolates to Aminoglycoside Antibiotics and Tigecycline

(2012) Deise Luiza Mahl et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cosubstrate Tolerance of the Aminoglycoside Resistance Enzyme Eis from Mycobacterium tuberculosis

(2012) Wenjing Chen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Aminoglycoside Multiacetylating Activity of the Enhanced Intracellular Survival Protein from Mycobacterium smegmatis and Its Inhibition

(2012) Wenjing Chen et al.   BIOCHEMISTRY

Efficacy of three drugs for protecting against gentamicin-induced hair cell and hearing losses

(2012) E Bas et al.   BRITISH JOURNAL OF PHARMACOLOGY

Selectively Guanidinylated Aminoglycosides as Antibiotics

(2012) Richard J. Fair et al.   ChemMedChem

Characterization of a compensatory mutant of Leishmania major that lacks ether lipids but exhibits normal growth, and G418 and hygromycin resistance

(2012) Rachel Zufferey et al.   EXPERIMENTAL PARASITOLOGY

Maternally transmitted aminoglycoside-induced and non-syndromic hearing loss caused by the 1494C > T mutation in the mitochondrial 12S rRNA gene in two Chinese families

(2012) Qinjun Wei et al.   INTERNATIONAL JOURNAL OF AUDIOLOGY

Aranorosin circumvents arbekacin-resistance in MRSA by inhibiting the bifunctional enzyme AAC(6′)/APH(2″)

(2012) Takuya Suga et al.   JOURNAL OF ANTIBIOTICS

Antibacterial activity of amphiphilic tobramycin

(2012) Ramesh Dhondikubeer et al.   JOURNAL OF ANTIBIOTICS

Combination of paromomycin and miltefosine promotes TLR4-dependent induction of antileishmanial immune response in vitro

(2012) S. Das et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Unexpected N-acetylation of capreomycin by mycobacterial Eis enzymes

(2012) J. L. Houghton et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Structural Basis for Dual Nucleotide Selectivity of Aminoglycoside 2″-Phosphotransferase IVa Provides Insight on Determinants of Nucleotide Specificity of Aminoglycoside Kinases

(2012) Kun Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aminoglycoside 2′′-Phosphotransferase IIIa (APH(2′′)-IIIa) Prefers GTP over ATP

(2012) Clyde A. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity of Plazomicin (ACHN-490) against MDR clinical isolates ofKlebsiella pneumoniae, Escherichia coli, andEnterobacterspp. from Athens, Greece

(2012) Irene Galani et al.   JOURNAL OF CHEMOTHERAPY

Design, Synthesis, and Antibacterial Activities of Conformationally Constrained Kanamycin A Derivatives

(2012) Wenxuan Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Prevention of gentamicin-induced apoptosis with the mitochondria-targeted antioxidant mitoquinone

(2012) Carolyn P. Ojano-Dirain et al.   LARYNGOSCOPE

Biochemical and structural analysis of aminoglycoside acetyltransferase Eis from Anabaena variabilis

(2012) Rachel E. Pricer et al.   Molecular BioSystems

Synthesis and Antibacterial Activities of Amphiphilic Neomycin B-based Bilipid Conjugates and Fluorinated Neomycin B-based Lipids

(2012) Smritilekha Bera et al.   MOLECULES

2-Deoxystreptamine-containing aminoglycoside antibiotics: Recent advances in the characterization and manipulation of their biosynthetic pathways

(2012) Sung Ryeol Park et al.   NATURAL PRODUCT REPORTS

Allosteric control of the ribosome by small-molecule antibiotics

(2012) Leyi Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin

(2012) T. Matt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7

(2012) K. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design of membrane targeting tobramycin-based cationic amphiphiles with reduced hemolytic activity

(2012) Ido M. Herzog et al.   MedChemComm

Riboswitches: Discovery of Drugs That Target Bacterial Gene-Regulatory RNAs

(2011) Katherine E. Deigan et al.   ACCOUNTS OF CHEMICAL RESEARCH

Antimony-Resistant Clinical Isolates of Leishmania donovani Are Susceptible to Paromomycin and Sitamaquine

(2011) Arpita Kulshrestha et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetics and Safety of Single and Multiple Doses of ACHN-490 Injection Administered Intravenously in Healthy Subjects

(2011) Robert T. Cass et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VivoEfficacy of the Novel Aminoglycoside ACHN-490 in Murine Infection Models

(2011) Noe Reyes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phylogenetic Sequence Variations in Bacterial rRNA Affect Species-Specific Susceptibility to Drugs Targeting Protein Synthesis

(2011) Subramanian Akshay et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular Recognition of 6′-N-5-Hexynoate Kanamycin A and RNA 1x1 Internal Loops Containing CA Mismatches

(2011) Tuan Tran et al.   BIOCHEMISTRY

The Pseudomonas aeruginosa membranes: A target for a new amphiphilic aminoglycoside derivative?

(2011) Myriam Ouberai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Synthesis and antibacterial activity of amphiphilic lysine-ligated neomycin B conjugates

(2011) Smritilekha Bera et al.   CARBOHYDRATE RESEARCH

A Small Molecule Discrimination Map of the Antibiotic Resistance Kinome

(2011) Tushar Shakya et al.   CHEMISTRY & BIOLOGY

Identification and Characterization of Inhibitors of the Aminoglycoside Resistance Acetyltransferase Eis from Mycobacterium tuberculosis

(2011) Keith D. Green et al.   ChemMedChem

Pharmacological Considerations for the Proper Clinical Use of Aminoglycosides

(2011) Spyridon Pagkalis et al.   DRUGS

PTC124-Mediated Translational Readthrough of a Nonsense Mutation Causing Usher Syndrome Type 1C

(2011) T. Goldmann et al.   HUMAN GENE THERAPY

Suppression of CFTR premature termination codons and rescue of CFTR protein and function by the synthetic aminoglycoside NB54

(2011) Steven M. Rowe et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Neomycin−Neomycin Dimer: An All-Carbohydrate Scaffold with High Affinity for AT-Rich DNA Duplexes

(2011) Sunil Kumar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Current Status of Pharmaceutical and Genetic Therapeutic Approaches to Treat DMD

(2011) Christophe Pichavant et al.   MOLECULAR THERAPY

Protective effect of N-acetylcysteine from drug-induced ototoxicity in uraemic patients with CAPD peritonitis

(2011) B. Tokgoz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

In vitro protection of auditory hair cells by salicylate from the gentamicin-induced but not neomycin-induced cell loss

(2011) Birgit Mazurek et al.   NEUROSCIENCE LETTERS

Rescue of Melanocortin 4 Receptor (MC4R) Nonsense Mutations by Aminoglycoside-Mediated Read-Through

(2011) Harald Brumm et al.   Obesity

Ex Vivo Treatment with a Novel Synthetic Aminoglycoside NB54 in Primary Fibroblasts from Rett Syndrome Patients Suppresses MECP2 Nonsense Mutations

(2011) Manuela Vecsler et al.   PLoS One

Crystal Structures of Two Aminoglycoside Kinases Bound with a Eukaryotic Protein Kinase Inhibitor

(2011) Desiree H. Fong et al.   PLoS One

Functional Hair Cell Mechanotransducer Channels Are Required for Aminoglycoside Ototoxicity

(2011) Abdelrahman Alharazneh et al.   PLoS One

Readthrough of Premature Termination Codons in the Adenomatous Polyposis Coli Gene Restores Its Biological Activity in Human Cancer Cells

(2011) Célia Floquet et al.   PLoS One

Paromomycin Affects Translation and Vesicle-Mediated Trafficking as Revealed by Proteomics of Paromomycin –Susceptible –Resistant Leishmania donovani

(2011) Bhavna Chawla et al.   PLoS One

Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB

(2011) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the Bacterial Ribosome in Classical and Hybrid States of tRNA Binding

(2011) J. A. Dunkle et al.   SCIENCE

Genetic Reconstruction of Protozoan rRNA Decoding Sites Provides a Rationale for Paromomycin Activity against Leishmania and Trypanosoma

(2011) Sven N. Hobbie et al.   PLoS Neglected Tropical Diseases

Highly Modular Structure and Ligand Binding by Conformational Capture in a Minimalistic Riboswitch

(2010) Elke Duchardt-Ferner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nucleotide Selectivity of Antibiotic Kinases

(2010) T. Shakya et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Differential Effects of Paromomycin on Ribosomes ofLeishmania mexicanaand Mammalian Cells

(2010) Marisa M. Fernández et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and Spectrum of the Neoglycoside ACHN-490

(2010) J. B. Aggen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Dissecting the cosubstrate structure requirements of the Staphylococcus aureus aminoglycoside resistance enzyme ANT(4′)

(2010) Vanessa R. Porter et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Two-Dimensional Combinatorial Screening of a Bacterial rRNA A-Site-like Motif Library: Defining Privileged Asymmetric Internal Loops That Bind Aminoglycosides

(2010) Tuan Tran et al.   BIOCHEMISTRY

NMR resonance assignments of an engineered neomycin-sensing riboswitch RNA bound to ribostamycin and tobramycin

(2010) Sina R. Schmidtke et al.   Biomolecular NMR Assignments

Repairing faulty genes by aminoglycosides: Development of new derivatives of geneticin (G418) with enhanced suppression of diseases-causing nonsense mutations

(2010) Igor Nudelman et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Evaluation of amphiphilic aminoglycoside–peptide triazole conjugates as antibacterial agents

(2010) Smritilekha Bera et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Future of Aminoglycosides: The End or Renaissance?

(2010) Jacob L. Houghton  et al.   CHEMBIOCHEM

Three Decades of  -Lactamase Inhibitors

(2010) S. M. Drawz et al.   CLINICAL MICROBIOLOGY REVIEWS

Cellular mechanisms of aminoglycoside ototoxicity

(2010) Mark E Warchol   Current Opinion in Otolaryngology & Head and Neck Surgery

Aminoglycoside modifying enzymes

(2010) Maria S. Ramirez et al.   DRUG RESISTANCE UPDATES

Antibacterial to antifungal conversion of neamine aminoglycosides through alkyl modification. Strategy for reviving old drugs into agrofungicides

(2010) Cheng-Wei T Chang et al.   JOURNAL OF ANTIBIOTICS

Antibacterial activity of guanidinylated neomycin B- and kanamycin A-derived amphiphilic lipid conjugates

(2010) Smritilekha Bera et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates

(2010) D. M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Antimicrobial activity of a novel aminoglycoside, ACHN-490, against Acinetobacter baumannii and Pseudomonas aeruginosa from New York City

(2010) D. Landman et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Activity of a novel aminoglycoside, ACHN-490, against clinical isolates of Escherichia coli and Klebsiella pneumoniae from New York City

(2010) D. Landman et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Antibacterial Activities of Aminoglycoside Antibiotics-Derived Cationic Amphiphiles. Polyol-Modified Neomycin B-, Kanamycin A-, Amikacin-, and Neamine-Based Amphiphiles with Potent Broad Spectrum Antibacterial Activity

(2010) Smritilekha Bera et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Role of L1 Stalk–tRNA Interaction in the Ribosome Elongation Cycle

(2010) Leonardo G. Trabuco et al.   JOURNAL OF MOLECULAR BIOLOGY

Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model

(2010) Cornelia Brendel et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

PELDOR Spectroscopy Reveals Preorganization of the Neomycin-Responsive Riboswitch Tertiary Structure

(2010) Ivan Krstić et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mitochondrial 12S rRNA mutations associated with aminoglycoside ototoxicity

(2010) Min-Xin Guan   MITOCHONDRION

Rescue of non-sense mutated p53 tumor suppressor gene by aminoglycosides

(2010) Célia Floquet et al.   NUCLEIC ACIDS RESEARCH

Binding of aminoglycoside antibiotics to helix 69 of 23S rRNA

(2010) Ann E. Scheunemann et al.   NUCLEIC ACIDS RESEARCH

Mechanistic insights into an engineered riboswitch: a switching element which confers riboswitch activity

(2010) Julia E. Weigand et al.   NUCLEIC ACIDS RESEARCH

Paromomycin for the Treatment of Visceral Leishmaniasis in Sudan: A Randomized, Open-Label, Dose-Finding Study

(2010) Ahmed M. Musa et al.   PLoS Neglected Tropical Diseases

Geographical Variation in the Response of Visceral Leishmaniasis to Paromomycin in East Africa: A Multicentre, Open-Label, Randomized Trial

(2010) Asrat Hailu et al.   PLoS Neglected Tropical Diseases

Aminoglycoside-induced mutation suppression (stop codon readthrough) as a therapeutic strategy for Duchenne muscular dystrophy

(2010) Vinod Malik et al.   Therapeutic Advances in Neurological Disorders

Rational and Modular Design of Potent Ligands Targeting the RNA That Causes Myotonic Dystrophy 2

(2009) Melissa M. Lee et al.   ACS Chemical Biology

In Vitro Activity of NXL104 in Combination with  -Lactams against Klebsiella pneumoniae Isolates Producing KPC Carbapenemases

(2009) A. Endimiani et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Subcutaneous administration of TC007 reduces disease severity in an animal model of SMA

(2009) Virginia B Mattis et al.   BMC NEUROSCIENCE

Delivery of a read-through inducing compound, TC007, lessens the severity of a spinal muscular atrophy animal model

(2009) Virginia B. Mattis et al.   HUMAN MOLECULAR GENETICS

Trafficking of Systemic Fluorescent Gentamicin into the Cochlea and Hair Cells

(2009) Qi Wang et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Synthesis and combinational antibacterial study of 5″-modified neomycin

(2009) Jianjun Zhang et al.   JOURNAL OF ANTIBIOTICS

Poly-l-aspartic Acid Enhances and Prolongs Gentamicin-mediated Suppression of theCFTR-G542X Mutation in a Cystic Fibrosis Mouse Model

(2009) Ming Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of Novel Aminoglycoside (NB54) with Reduced Toxicity and Enhanced Suppression of Disease-Causing Premature Stop Mutations

(2009) Igor Nudelman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Antimicrobial Evaluation of Amphiphilic Neamine Derivatives

(2009) Isabelle Baussanne et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aminoglycoside activity observed on single pre-translocation ribosome complexes

(2009) Michael B Feldman et al.   Nature Chemical Biology

Taurine attenuates aminoglycoside ototoxicity by inhibiting inducible nitric oxide synthase expression in the cochlea

(2009) Hai-ying Liu et al.   NEUROREPORT

Two-dimensional combinatorial screening and the RNA Privileged Space Predictor program efficiently identify aminoglycoside–RNA hairpin loop interactions

(2009) Dustin J. Paul et al.   NUCLEIC ACIDS RESEARCH

Suppression of Nonsense Mutations in Rett Syndrome by Aminoglycoside Antibiotics

(2009) Cornelia Brendel et al.   PEDIATRIC RESEARCH

Fluorescently labeled ribosomes as a tool for analyzing antibiotic binding

(2009) B. Llano-Sotelo et al.   RNA

WR279,396, a Third Generation Aminoglycoside Ointment for the Treatment of Leishmania major Cutaneous Leishmaniasis: A Phase 2, Randomized, Double Blind, Placebo Controlled Study

(2009) Afif Ben Salah et al.   PLoS Neglected Tropical Diseases

Two-Dimensional Combinatorial Screening Identifies Specific 6′-Acylated Kanamycin A− and 6′-Acylated Neamine−RNA Hairpin Interactions†

(2008) Olga Aminova et al.   BIOCHEMISTRY

Structure–toxicity relationship of aminoglycosides: Correlation of 2′-amine basicity with acute toxicity in pseudo-disaccharide scaffolds

(2008) Lilach Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease

(2008) M. Moosajee et al.   HUMAN MOLECULAR GENETICS

Surprising Alteration of Antibacterial Activity of 5′′-Modified Neomycin against Resistant Bacteria

(2008) Jianjun Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Antibacterial Activities of Neomycin−Lipid Conjugates: Polycationic Lipids with Potent Gram-Positive Activity

(2008) Smritilekha Bera et al.   JOURNAL OF MEDICINAL CHEMISTRY

Paromomycin: Uptake and resistance in Leishmania donovani

(2008) Anupam Jhingran et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The evolution of our thinking about microRNAs

(2008) Victor Ambros   NATURE MEDICINE

Mitochondrial deafness alleles confer misreading of the genetic code

(2008) S. N. Hobbie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model

(2008) M. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity

(2008) S. N. Hobbie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aminoglycoside induced ototoxicity

(2008) O’neil W. Guthrie   TOXICOLOGY

Introducing sense into nonsense in treatments of human genetic diseases

(2008) Liat Linde et al.   TRENDS IN GENETICS

Drug-induced readthrough of premature stop codons leads to the stabilization of laminin α2 chain mRNA in CMD myotubes

(2007) Valérie Allamand et al.   JOURNAL OF GENE MEDICINE

Designer aminoglycosides: the race to develop improved antibiotics and compounds for the treatment of human genetic diseases

(2007) Mariana Hainrichson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY