Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections
Authors
Keywords
-
Journal
Future Medicinal Chemistry
Volume 5, Issue 11, Pages 1285-1309
Publisher
Future Science, LTD
Online
2013-07-17
DOI
10.4155/fmc.13.80
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Direct Observation of Aminoglycoside–RNA Binding by Localized Surface Plasmon Resonance Spectroscopy
- (2013) Ludmila Frolov et al. ANALYTICAL CHEMISTRY
- Domain dissection and characterization of the aminoglycoside resistance enzyme ANT(3″)-Ii/AAC(6′)-IId from Serratia marcescens
- (2013) Keith D. Green et al. BIOCHIMIE
- Molecular genetics of Mycobacterium tuberculosis resistant to aminoglycosides and cyclic peptide capreomycin antibiotics in Korea
- (2013) Hum Nath Jnawali et al. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
- Inhibitors of Aminoglycoside Resistance Activated in Cells
- (2012) Kenward Vong et al. ACS Chemical Biology
- A fluorescence-based screen for ribosome binding antibiotics
- (2012) Derrick Watkins et al. ANALYTICAL BIOCHEMISTRY
- 6′′-Thioether Tobramycin Analogues: Towards Selective Targeting of Bacterial Membranes
- (2012) Ido M. Herzog et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Small-Angle X-Ray Scattering Analysis of the Bifunctional Antibiotic Resistance Enzyme Aminoglycoside (6′) Acetyltransferase-Ie/Aminoglycoside (2″) Phosphotransferase-Ia Reveals a Rigid Solution Structure
- (2012) Shane J. Caldwell et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Aminoglycoside Multiacetylating Activity of the Enhanced Intracellular Survival Protein from Mycobacterium smegmatis and Its Inhibition
- (2012) Wenjing Chen et al. BIOCHEMISTRY
- Selectively Guanidinylated Aminoglycosides as Antibiotics
- (2012) Richard J. Fair et al. ChemMedChem
- Improving known classes of antibiotics: an optimistic approach for the future
- (2012) Karen Bush CURRENT OPINION IN PHARMACOLOGY
- Development of Aminoglycoside Antibiotics Effective Against Resistant Bacterial Strains
- (2012) Lin Yang et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Comparison of the next-generation aminoglycoside plazomicin to gentamicin, tobramycin and amikacin
- (2012) George G Zhanel et al. Expert Review of Anti-Infective Therapy
- Increased high-level gentamicin resistance in invasiveEnterococcus faeciumis associated withaac(6′)Ie-aph(2″)Ia-encoding transferable megaplasmids hosted by major hospital-adapted lineages
- (2012) Torill C.S. Rosvoll et al. FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
- Microevolution of extensively drug-resistant tuberculosis in Russia
- (2012) N. Casali et al. GENOME RESEARCH
- Aranorosin circumvents arbekacin-resistance in MRSA by inhibiting the bifunctional enzyme AAC(6′)/APH(2″)
- (2012) Takuya Suga et al. JOURNAL OF ANTIBIOTICS
- Antibacterial activity of amphiphilic tobramycin
- (2012) Ramesh Dhondikubeer et al. JOURNAL OF ANTIBIOTICS
- Unexpected N-acetylation of capreomycin by mycobacterial Eis enzymes
- (2012) J. L. Houghton et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- From multidrug-resistant to extensively drug-resistant tuberculosis in Lisbon, Portugal: the stepwise mode of resistance acquisition
- (2012) J. Perdigao et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- The role of eis mutations in the development of kanamycin resistance in Mycobacterium tuberculosis isolates from the Moscow region
- (2012) M. B. Gikalo et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Revisiting the Nucleotide and Aminoglycoside Substrate Specificity of the Bifunctional Aminoglycoside Acetyltransferase(6′)-Ie/Aminoglycoside Phosphotransferase(2″)-Ia Enzyme
- (2012) Hilary Frase et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural Basis for Dual Nucleotide Selectivity of Aminoglycoside 2″-Phosphotransferase IVa Provides Insight on Determinants of Nucleotide Specificity of Aminoglycoside Kinases
- (2012) Kun Shi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Aminoglycoside 2′′-Phosphotransferase IIIa (APH(2′′)-IIIa) Prefers GTP over ATP
- (2012) Clyde A. Smith et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activity of Plazomicin (ACHN-490) against MDR clinical isolates ofKlebsiella pneumoniae, Escherichia coli, andEnterobacterspp. from Athens, Greece
- (2012) Irene Galani et al. JOURNAL OF CHEMOTHERAPY
- Detection of First- and Second-Line Drug Resistance in Mycobacterium tuberculosis Clinical Isolates by Pyrosequencing
- (2012) Anna Engström et al. JOURNAL OF CLINICAL MICROBIOLOGY
- Biochemical and structural analysis of aminoglycoside acetyltransferase Eis from Anabaena variabilis
- (2012) Rachel E. Pricer et al. Molecular BioSystems
- Synthesis and Antibacterial Activities of Amphiphilic Neomycin B-based Bilipid Conjugates and Fluorinated Neomycin B-based Lipids
- (2012) Smritilekha Bera et al. MOLECULES
- 2-Deoxystreptamine-containing aminoglycoside antibiotics: Recent advances in the characterization and manipulation of their biosynthetic pathways
- (2012) Sung Ryeol Park et al. NATURAL PRODUCT REPORTS
- Evaluation of Genetic Mutations Associated with Mycobacterium tuberculosis Resistance to Amikacin, Kanamycin and Capreomycin: A Systematic Review
- (2012) Sophia B. Georghiou et al. PLoS One
- Exploiting Adaptive Laboratory Evolution of Streptomyces clavuligerus for Antibiotic Discovery and Overproduction
- (2012) Pep Charusanti et al. PLoS One
- Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin
- (2012) T. Matt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7
- (2012) K. H. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Activity of ACHN-490 Tested Alone and in Combination with Other Agents against Pseudomonas aeruginosa
- (2011) Glenn A. Pankuch et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Effects of Altering Aminoglycoside Structures on Bacterial Resistance Enzyme Activities
- (2011) Keith D. Green et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Pharmacokinetics and Safety of Single and Multiple Doses of ACHN-490 Injection Administered Intravenously in Healthy Subjects
- (2011) Robert T. Cass et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- In VivoEfficacy of the Novel Aminoglycoside ACHN-490 in Murine Infection Models
- (2011) Noe Reyes et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Crystal Structures of Antibiotic-Bound Complexes of Aminoglycoside 2′′-Phosphotransferase IVa Highlight the Diversity in Substrate Binding Modes among Aminoglycoside Kinases
- (2011) Kun Shi et al. BIOCHEMISTRY
- Synthesis and Spectroscopic Studies of the Aminoglycoside (Neomycin)−Perylene Conjugate Binding to Human Telomeric DNA
- (2011) Liang Xue et al. BIOCHEMISTRY
- Identification and Characterization of New Inhibitors of Fungal Homoserine Kinase
- (2011) Gianfranco De Pascale et al. CHEMBIOCHEM
- Molecular mechanisms of antibiotic resistance
- (2011) Gerard D. Wright CHEMICAL COMMUNICATIONS
- A Small Molecule Discrimination Map of the Antibiotic Resistance Kinome
- (2011) Tushar Shakya et al. CHEMISTRY & BIOLOGY
- Inhibition of Aminoglycoside-Deactivating Enzymes APH(3′)-IIIa and AAC(6′)-Ii by Amphiphilic Paromomycin O2′′-Ether Analogues
- (2011) Janek Szychowski et al. ChemMedChem
- Identification and Characterization of Inhibitors of the Aminoglycoside Resistance Acetyltransferase Eis from Mycobacterium tuberculosis
- (2011) Keith D. Green et al. ChemMedChem
- Antibiotic adjuvants: multicomponent anti-infective strategies
- (2011) Lindsay Kalan et al. EXPERT REVIEWS IN MOLECULAR MEDICINE
- Activity of ACHN-490 against meticillin-resistant Staphylococcus aureus (MRSA) isolates from patients in US hospitals
- (2011) Fred C. Tenover et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Structural Analysis of a Putative Aminoglycoside N-Acetyltransferase from Bacillus anthracis
- (2011) Maria M. Klimecka et al. JOURNAL OF MOLECULAR BIOLOGY
- Neomycin−Neomycin Dimer: An All-Carbohydrate Scaffold with High Affinity for AT-Rich DNA Duplexes
- (2011) Sunil Kumar et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The designer aminoglycoside NB84 significantly reduces glycosaminoglycan accumulation associated with MPS I-H in the Idua-W392X mouse
- (2011) Dan Wang et al. MOLECULAR GENETICS AND METABOLISM
- Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy
- (2011) Linda Ejim et al. Nature Chemical Biology
- Assessment of 6′- and 6′′′-N-acylation of aminoglycosides as a strategy to overcome bacterial resistance
- (2011) Pazit Shaul et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Hybrid Aminoglycoside AntibioticsviaTsuji Palladium-Catalyzed Allylic Deoxygenation
- (2011) Stephen Hanessian et al. ORGANIC LETTERS
- Crystal Structures of Two Aminoglycoside Kinases Bound with a Eukaryotic Protein Kinase Inhibitor
- (2011) Desiree H. Fong et al. PLoS One
- Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB
- (2011) W. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Biverlactones A–D, new circumventors of arbekacin resistance in MRSA, produced by Penicillium sp. FKI-4429
- (2011) Masato Iwatsuki et al. TETRAHEDRON
- Understanding and overcoming aminoglycoside resistance caused by N-6′-acetyltransferase
- (2011) Kenward Vong et al. MedChemComm
- Synthetic RNA Silencing in Bacteria ? Antimicrobial Discovery and Resistance Breaking
- (2011) Liam Good et al. Frontiers in Microbiology
- Nucleotide Selectivity of Antibiotic Kinases
- (2010) T. Shakya et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Antistaphylococcal Activity of ACHN-490 Tested Alone and in Combination with Other Agents by Time-Kill Assay
- (2010) G. Lin et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Synthesis and Spectrum of the Neoglycoside ACHN-490
- (2010) J. B. Aggen et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Dissecting the cosubstrate structure requirements of the Staphylococcus aureus aminoglycoside resistance enzyme ANT(4′)
- (2010) Vanessa R. Porter et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Repairing faulty genes by aminoglycosides: Development of new derivatives of geneticin (G418) with enhanced suppression of diseases-causing nonsense mutations
- (2010) Igor Nudelman et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Rational design and synthesis of potent aminoglycoside antibiotics against resistant bacterial strains
- (2010) Ri-Bai Yan et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: A synergistic hydrophobic effect against resistant bacteria
- (2010) Stephen Hanessian et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Evaluation of amphiphilic aminoglycoside–peptide triazole conjugates as antibacterial agents
- (2010) Smritilekha Bera et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- A Chemoenzymatic Route to Diversify Aminolgycosides Enables a Microarray-Based Method to Probe Acetyltransferase Activity
- (2010) Pavel B. Tsitovich et al. CHEMBIOCHEM
- The Future of Aminoglycosides: The End or Renaissance?
- (2010) Jacob L. Houghton et al. CHEMBIOCHEM
- Three Decades of -Lactamase Inhibitors
- (2010) S. M. Drawz et al. CLINICAL MICROBIOLOGY REVIEWS
- Combating evolution with intelligent design: the neoglycoside ACHN-490
- (2010) Eliana S Armstrong et al. CURRENT OPINION IN MICROBIOLOGY
- Aminoglycoside modifying enzymes
- (2010) Maria S. Ramirez et al. DRUG RESISTANCE UPDATES
- Antibiotic biosynthesis following horizontal gene transfer: new milestone for novel natural product discovery?
- (2010) Kazuhiko Kurosawa et al. Expert Opinion on Drug Discovery
- Dual-acting hybrid antibiotics: a promising strategy to combat bacterial resistance
- (2010) Varvara Pokrovskaya et al. Expert Opinion on Drug Discovery
- New aminoglycoside antibiotics
- (2010) Paola Dozzo et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Antibacterial activity of guanidinylated neomycin B- and kanamycin A-derived amphiphilic lipid conjugates
- (2010) Smritilekha Bera et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates
- (2010) D. M. Livermore et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Antimicrobial activity of a novel aminoglycoside, ACHN-490, against Acinetobacter baumannii and Pseudomonas aeruginosa from New York City
- (2010) D. Landman et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Activity of a novel aminoglycoside, ACHN-490, against clinical isolates of Escherichia coli and Klebsiella pneumoniae from New York City
- (2010) D. Landman et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Structure of the Antibiotic Resistance Factor Spectinomycin Phosphotransferase fromLegionella pneumophila
- (2010) Desiree H. Fong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure and Function of APH(4)-Ia, a Hygromycin B Resistance Enzyme
- (2010) Peter J. Stogios et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Antibacterial Activities of Aminoglycoside Antibiotics-Derived Cationic Amphiphiles. Polyol-Modified Neomycin B-, Kanamycin A-, Amikacin-, and Neamine-Based Amphiphiles with Potent Broad Spectrum Antibacterial Activity
- (2010) Smritilekha Bera et al. JOURNAL OF MEDICINAL CHEMISTRY
- Crystal structure and kinetic mechanism of aminoglycoside phosphotransferase-2″-IVa
- (2010) Marta Toth et al. PROTEIN SCIENCE
- Structural Basis of APH(3')-IIIa-Mediated Resistance to N1-Substituted Aminoglycoside Antibiotics
- (2009) D. H. Fong et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- In Vitro Activity of NXL104 in Combination with -Lactams against Klebsiella pneumoniae Isolates Producing KPC Carbapenemases
- (2009) A. Endimiani et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Exploring the Substrate Promiscuity of Drug-Modifying Enzymes for the Chemoenzymatic Generation of N-Acylated Aminoglycosides
- (2009) Keith D. Green et al. CHEMBIOCHEM
- Synthesis of a Phosphonate-Linked Aminoglycoside-Coenzyme A Bisubstrate and Use in Mechanistic Studies of an Enzyme Involved in Aminoglycoside Resistance
- (2009) Feng Gao et al. CHEMISTRY-A EUROPEAN JOURNAL
- The Crystal Structures of Substrate and Nucleotide Complexes of Enterococcus faecium Aminoglycoside-2''-Phosphotransferase-IIa [APH(2'')-IIa] Provide Insights into Substrate Selectivity in the APH(2'') Subfamily
- (2009) P. G. Young et al. JOURNAL OF BACTERIOLOGY
- Search for Novel Aminoglycosides by Combining Fragment-Based Virtual Screening and 3D-QSAR Scoring
- (2009) Piotr Setny et al. Journal of Chemical Information and Modeling
- Design, Synthesis, and Evaluation of Novel Fluoroquinolone−Aminoglycoside Hybrid Antibiotics
- (2009) Varvara Pokrovskaya et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and Antimicrobial Evaluation of Amphiphilic Neamine Derivatives
- (2009) Isabelle Baussanne et al. JOURNAL OF MEDICINAL CHEMISTRY
- Overexpression of the chromosomally encoded aminoglycoside acetyltransferase eis confers kanamycin resistance in Mycobacterium tuberculosis
- (2009) M. A. Zaunbrecher et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis
- (2009) J.-E. Hugonnet et al. SCIENCE
- Mechanistic and Structural Analysis of AminoglycosideN-Acetyltransferase AAC(6′)-Ib and Its Bifunctional, Fluoroquinolone-Active AAC(6′)-Ib-cr Variant†‡
- (2008) Matthew W. Vetting et al. BIOCHEMISTRY
- Synthesis and use of sulfonamide-, sulfoxide-, or sulfone-containing aminoglycoside–CoA bisubstrates as mechanistic probes for aminoglycoside N-6′-acetyltransferase
- (2008) Feng Gao et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- NMR-Guided Fragment-Based Approach for the Design of AAC(6′)-Ib Ligands
- (2008) Thomas Lombès et al. CHEMBIOCHEM
- Chemoenzymatic acylation of aminoglycoside antibiotics
- (2008) Nicholas M. Llewellyn et al. CHEMICAL COMMUNICATIONS
- Design, Synthesis, and Antibacterial Activities of Neomycin−Lipid Conjugates: Polycationic Lipids with Potent Gram-Positive Activity
- (2008) Smritilekha Bera et al. JOURNAL OF MEDICINAL CHEMISTRY
- Two-Dimensional Combinatorial Screening Identifies Specific Aminoglycoside−RNA Internal Loop Partners
- (2008) Matthew D. Disney et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Rhodostreptomycins, Antibiotics Biosynthesized Following Horizontal Gene Transfer fromStreptomyces padanustoRhodococcus fascians
- (2008) Kazuhiko Kurosawa et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- High-throughput kinase profiling as a platform for drug discovery
- (2008) David M. Goldstein et al. NATURE REVIEWS DRUG DISCOVERY
- Kinetic and Structural Analysis of Bisubstrate Inhibition of theSalmonella entericaAminoglycoside 6‘-N-Acetyltransferase†,‡
- (2007) Maria L. B. Magalhães et al. BIOCHEMISTRY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now