Chemical reporters for biological discovery

A Chemical Probe for Lysine Malonylation

(2013) Xiucong Bao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

(2013) Hong Jiang et al.   NATURE

Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ

(2013) Nikolay Burnaevskiy et al.   NATURE

QuaNCAT: quantitating proteome dynamics in primary cells

(2013) Andrew J M Howden et al.   NATURE METHODS

The Cellular and Molecular Basis of Bitter Tastant-Induced Bronchodilation

(2013) Cheng-Hai Zhang et al.   PLOS BIOLOGY

Tracing Fatty Acid Metabolism by Click Chemistry

(2012) Christoph Thiele et al.   ACS Chemical Biology

Protein Lysine Acylation and Cysteine Succination by Intermediates of Energy Metabolism

(2012) Hening Lin et al.   ACS Chemical Biology

Live-Cell Imaging of Cyclopropene Tags with Fluorogenic Tetrazine Cycloadditions

(2012) Jun Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Click-Mediated Labeling of Bacterial Membranes through Metabolic Modification of the Lipopolysaccharide Inner Core

(2012) Audrey Dumont et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Reporters for Monitoring RNA Synthesis and Poly(A) Tail Dynamics

(2012) Markus Grammel et al.   CHEMBIOCHEM

A Selenium-Based Click AdoMet Analogue for Versatile Substrate Labeling with Wild-Type Protein Methyltransferases

(2012) Sophie Willnow et al.   CHEMBIOCHEM

Se-Adenosyl-l-selenomethionine Cofactor Analogue as a Reporter of Protein Methylation

(2012) Ian R. Bothwell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetic Encoding of Bicyclononynes and trans-Cyclooctenes for Site-Specific Protein Labeling in Vitro and in Live Mammalian Cells via Rapid Fluorogenic Diels–Alder Reactions

(2012) Kathrin Lang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Probing the Mycobacterial Trehalome with Bioorthogonal Chemistry

(2012) Benjamin M. Swarts et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell-Selective Metabolic Glycan Labeling Based on Ligand-Targeted Liposomes

(2012) Ran Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Profiling Genome-Wide Chromatin Methylation with Engineered Posttranslation Apparatus within Living Cells

(2012) Rui Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective enrichment of newly synthesized proteins for quantitative secretome analysis

(2012) Katrin Eichelbaum et al.   NATURE BIOTECHNOLOGY

Expanding the genetic code of Drosophila melanogaster

(2012) Ambra Bianco et al.   Nature Chemical Biology

Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation

(2012) Jessica E Rexach et al.   Nature Chemical Biology

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

(2012) Bryan A. Gibson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic click-labeling with a fucose analog reveals pectin delivery, architecture, and dynamics in Arabidopsis cell walls

(2012) C. T. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions

(2011) Ellen M. Sletten et al.   ACCOUNTS OF CHEMICAL RESEARCH

Bioorthogonal Chemical Reporters for Analyzing Protein Lipidation and Lipid Trafficking

(2011) Howard C. Hang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Biomedical Applications of Tetrazine Cycloadditions

(2011) Neal K. Devaraj et al.   ACCOUNTS OF CHEMICAL RESEARCH

Expanding Cofactor Repertoire of Protein Lysine Methyltransferase for Substrate Labeling

(2011) Kabirul Islam et al.   ACS Chemical Biology

Tracking N-Acetyllactosamine on Cell-Surface Glycans In Vivo

(2011) Tianqing Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease

(2011) Gerald W. Hart et al.   Annual Review of Biochemistry

Identification of lysine acetyltransferase p300 substrates using 4-pentynoyl-coenzyme A and bioorthogonal proteomics

(2011) Yang Yu-Ying et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Intracellular Detection of Cytosine Incorporation in Genomic DNA by Using 5-Ethynyl-2′-Deoxycytidine

(2011) Lirui Guan et al.   CHEMBIOCHEM

Bioorthogonal chemical tagging of protein cholesterylation in living cells

(2011) William P. Heal et al.   CHEMICAL COMMUNICATIONS

Cell-selective labeling of bacterial proteomes with an orthogonal phenylalanine amino acid reporter

(2011) Markus Grammel et al.   CHEMICAL COMMUNICATIONS

DHHC5 Protein Palmitoylates Flotillin-2 and Is Rapidly Degraded on Induction of Neuronal Differentiation in Cultured Cells

(2011) Yi Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Chemical Reporter for Protein AMPylation

(2011) Markus Grammel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Labeling Substrates of Protein Arginine Methyltransferase with Engineered Enzymes and MatchedS-Adenosyl-l-methionine Analogues

(2011) Rui Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expanding the Genetic Code of an Animal

(2011) Sebastian Greiss et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Imaging of EdU, an Alkyne-Tagged Cell Proliferation Probe, by Raman Microscopy

(2011) Hiroyuki Yamakoshi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Legionella pneumophila SidD is a deAMPylase that modifies Rab1

(2011) Yunhao Tan et al.   NATURE

Chemical contrast for imaging living systems: molecular vibrations drive CARS microscopy

(2011) John Paul Pezacki et al.   Nature Chemical Biology

Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity

(2011) Candice E Paulsen et al.   Nature Chemical Biology

Global profiling of dynamic protein palmitoylation

(2011) Brent R Martin et al.   NATURE METHODS

Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1

(2011) B. W. Zaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic metabolic labeling of DNA in vivo with arabinosyl nucleosides

(2011) A. B. Neef et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin

(2011) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

(2011) Y.-F. He et al.   SCIENCE

Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

(2011) S. Ito et al.   SCIENCE

AMPylation: something old is new again

(2011) Andrew Woolery   Frontiers in Microbiology

Enzymatic Site-Specific Functionalization of Protein Methyltransferase Substrates with Alkynes for Click Labeling

(2010) Wibke Peters et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Adding New Chemistries to the Genetic Code

(2010) Chang C. Liu et al.   Annual Review of Biochemistry

Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation

(2010) Joseph Tcherkezian et al.   CELL

Evaluation of Alkyne-Modified Isoprenoids as Chemical Reporters of Protein Prenylation

(2010) Amanda J. DeGraw et al.   Chemical Biology & Drug Design

Residue-specific incorporation of non-canonical amino acids into proteins: recent developments and applications

(2010) Jeremiah A Johnson et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Bioorthogonal Chemical Reporters for Monitoring Protein Acetylation

(2010) Yu-Ying Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid Visualization and Large-Scale Profiling of Bacterial Lipoproteins with Chemical Reporters

(2010) Kavita J. Rangan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Strategy for the Selective Imaging of Glycans Using Caged Metabolic Precursors

(2010) Pamela V. Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Clickable NAD Analogues for Labeling Substrate Proteins of Poly(ADP-ribose) Polymerases

(2010) Hong Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alkynyl-farnesol reporters for detection ofproteinS-prenylation in cells

(2010) Guillaume Charron et al.   Molecular BioSystems

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine

(2010) Chun-Xiao Song et al.   NATURE BIOTECHNOLOGY

Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags

(2010) Jessica E Rexach et al.   Nature Chemical Biology

Palmitoylome profiling reveals S-palmitoylation–dependent antiviral activity of IFITM3

(2010) Jacob S Yount et al.   Nature Chemical Biology

Capture and release of alkyne-derivatized glycerophospholipids using cobalt chemistry

(2010) Stephen B Milne et al.   Nature Chemical Biology

In situ visualization and dynamics of newly synthesized proteins in rat hippocampal neurons

(2010) Daniela C Dieterich et al.   NATURE NEUROSCIENCE

Protein palmitoylation in neuronal development and synaptic plasticity

(2010) Yuko Fukata et al.   NATURE REVIEWS NEUROSCIENCE

Tandem fluorescence imaging of dynamic S-acylation and protein turnover

(2010) M. M. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Kinetics of Nucleosome Turnover Determined by Metabolic Labeling of Histones

(2010) R. B. Deal et al.   SCIENCE

The Legionella Effector Protein DrrA AMPylates the Membrane Traffic Regulator Rab1b

(2010) M. P. Muller et al.   SCIENCE

The Engineering of Bacteria Bearing Azido-Pseudaminic Acid-Modified Flagella

(2009) Feng Liu et al.   CHEMBIOCHEM

Cell-selective metabolic labeling of proteins

(2009) John T Ngo et al.   Nature Chemical Biology

Large-scale profiling of protein palmitoylation in mammalian cells

(2009) Brent R Martin et al.   NATURE METHODS

Metabolic labeling and direct imaging of choline phospholipids in vivo

(2009) C. Y. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans

(2009) T. Arnesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global and Site-Specific Quantitative Phosphoproteomics: Principles and Applications

(2008) Boris Macek et al.   Annual Review of Pharmacology and Toxicology

Cu-Catalyzed Azide−Alkyne Cycloaddition

(2008) Morten Meldal et al.   CHEMICAL REVIEWS

Lipid-independent Secretion of aDrosophilaWnt Protein

(2008) Wendy Ching et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity

(2008) Melissa L. Blackman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical approaches to understanding O-GlcNAc glycosylation in the brain

(2008) Jessica E Rexach et al.   Nature Chemical Biology

Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates

(2008) J. D. Blethrow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging the glycome

(2008) S. T. Laughlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A chemical method for fast and sensitive detection of DNA synthesis in vivo

(2008) A. Salic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploring RNA transcription and turnover in vivo by using click chemistry

(2008) C. Y. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish

(2008) S. T. Laughlin et al.   SCIENCE

AMPylation of Rho GTPases by Vibrio VopS Disrupts Effector Binding and Downstream Signaling

(2008) M. L. Yarbrough et al.   SCIENCE