Biosynthetic medicinal chemistry of natural product drugs

Marizomib, a Proteasome Inhibitor for All Seasons: Preclinical Profile and a Framework for Clinical Trials

(2011) B. C. Potts et al.   CURRENT CANCER DRUG TARGETS

Strategies to optimize the brain availability of central nervous system drug candidates

(2011) Travis T Wager et al.   Expert Opinion on Drug Discovery

Current and future directions in mammalian target of rapamycin inhibitors development

(2011) Angelica Fasolo et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Investigational antibody drug conjugates for solid tumors

(2011) Puja Sapra et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Fingolimod (FTY720): A Recently Approved Multiple Sclerosis Drug Based on a Fungal Secondary Metabolite

(2011) Cherilyn R. Strader et al.   JOURNAL OF NATURAL PRODUCTS

The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

(2011) Gilles P. van Wezel et al.   NATURAL PRODUCT REPORTS

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

The productivity crisis in pharmaceutical R&D

(2011) Fabio Pammolli et al.   NATURE REVIEWS DRUG DISCOVERY

Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate

(2011) J. N. Andexer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space

(2011) Alexander Alex et al.   MedChemComm

Salinosporamide Natural Products: Potent 20 S Proteasome Inhibitors as Promising Cancer Chemotherapeutics

(2010) Tobias A. M. Gulder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Heterologous Expression of the Oxytetracycline Biosynthetic Pathway in Myxococcus xanthus

(2010) D. C. Stevens et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Hsp90 inhibition: Elimination of shock and stress

(2010) Adam S. Duerfeldt et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes

(2010) Chantel D. Campbell et al.   BIOPOLYMERS

Biosynthesis of rapamycin and its regulation: past achievements and recent progress

(2010) Sung Ryeol Park et al.   JOURNAL OF ANTIBIOTICS

Origin of the Allyl Group in FK506 Biosynthesis

(2010) Dušan Goranovič et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineering Fluorometabolite Production: Fluorinase Expression inSalinispora tropicaYields Fluorosalinosporamide†

(2010) Alessandra S. Eustáquio et al.   JOURNAL OF NATURAL PRODUCTS

Natural Products Version 2.0: Connecting Genes to Molecules

(2010) Christopher T. Walsh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of the Allylmalonyl-CoA Extender Unit for the FK506 Polyketide Synthase Proceeds through a Dedicated Polyketide Synthase and Facilitates the Mutasynthesis of Analogues

(2010) SangJoon Mo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Generating a Generation of Proteasome Inhibitors: From Microbial Fermentation to Total Synthesis of Salinosporamide A (Marizomib) and Other Salinosporamides

(2010) Barbara C. Potts et al.   Marine Drugs

Grand Challenge Commentary: Accessing new chemical space for 'undruggable' targets

(2010) Sivaraman Dandapani et al.   Nature Chemical Biology

Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms

(2010) Marnix H. Medema et al.   NATURE REVIEWS MICROBIOLOGY

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

Geldanamycin and its anti-cancer activities

(2009) Yayoi Fukuyo et al.   CANCER LETTERS

New, Highly Active Nonbenzoquinone Geldanamycin Derivatives by Using Mutasynthesis

(2009) Simone Eichner et al.   CHEMBIOCHEM

Rational Biosynthetic Engineering for Optimization of Geldanamycin Analogues

(2009) Woncheol Kim et al.   CHEMBIOCHEM

Simultaneous determination of epothilone D and its hydrolytic metabolite in human plasma by high performance liquid chromatography–tandem mass spectrometry for pharmacokinetic studies

(2009) Chunling Zhang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Snapshots of the Fluorosalinosporamide/20S Complex Offer Mechanistic Insights for Fine Tuning Proteasome Inhibition

(2009) Michael Groll et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Chemical Space Exploration via Natural Products

(2009) Josefin Rosén et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanism of action of everolimus in renal cell carcinoma

(2009) Bernard Escudier et al.   MEDICAL ONCOLOGY

Recent advances in the chemistry, biosynthesis and pharmacology of rapamycin analogs

(2009) Edmund I. Graziani   NATURAL PRODUCT REPORTS

Development of Yondelis® (trabectedin, ET-743). A semisynthetic process solves the supply problem

(2009) Carmen Cuevas et al.   NATURAL PRODUCT REPORTS

Metabolic reprogramming of periwinkle plant culture

(2009) Weerawat Runguphan et al.   Nature Chemical Biology

Lessons from 60 years of pharmaceutical innovation

(2009) Bernard Munos   NATURE REVIEWS DRUG DISCOVERY

The influence of lead discovery strategies on the properties of drug candidates

(2009) György M. Keserü et al.   NATURE REVIEWS DRUG DISCOVERY

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine

(2009) A. S. Eustaquio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutasynthesis of Fluorosalinosporamide, a Potent and Reversible Inhibitor of the Proteasome

(2008) Alessandra S. Eustáquio et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Accessing natural product biosynthetic processes by mass spectrometry

(2008) Stefanie B Bumpus et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The impact of natural products upon modern drug discovery

(2008) A Ganesan   CURRENT OPINION IN CHEMICAL BIOLOGY

Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides

(2008) Rama Rao Manam et al.   JOURNAL OF MEDICINAL CHEMISTRY

Optimizing Natural Products by Biosynthetic Engineering: Discovery of Nonquinone Hsp90 Inhibitors†

(2008) Ming-Qiang Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Engineered Biosynthesis of Antiprotealide and Other Unnatural Salinosporamide Proteasome Inhibitors

(2008) Ryan P. McGlinchey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heterologous Expression And Genetic Engineering of the Phenalinolactone Biosynthetic Gene Cluster by Using Red/ET Recombineering

(2007) Tina M. Binz et al.   CHEMBIOCHEM

Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites

(2007) Kyeong Lee et al.   ORGANIC & BIOMOLECULAR CHEMISTRY