Strategies to optimize the brain availability of central nervous system drug candidates

Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes

(2010) Travis T. Wager et al.   ACS Chemical Neuroscience

Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties

(2010) Travis T. Wager et al.   ACS Chemical Neuroscience

Estimation of ADME Properties with Substructure Pattern Recognition

(2010) Jie Shen et al.   Journal of Chemical Information and Modeling

N-Methyl Phenylalanine-Rich Peptides as Highly Versatile Blood−Brain Barrier Shuttles

(2010) Morteza Malakoutikhah et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug Targeting of Erythropoietin Across the Primate Blood-Brain Barrier with an IgG Molecular Trojan Horse

(2010) R. J. Boado et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Ensemble Rule-Based Classification of Substrates of the Human ABC-Transporter ABCB1 Using Simple Physicochemical Descriptors

(2010) Michael A. Demel et al.   Molecular Informatics

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid concentrations in rhesus monkeys

(2009) Cuyue Tang et al.   BIOCHEMICAL PHARMACOLOGY

Development of Decision Tree Models for Substrates, Inhibitors, and Inducers of P-Glycoprotein

(2009) Felix Hammann et al.   CURRENT DRUG METABOLISM

Brain drug targeting: a computational approach for overcoming blood–brain barrier

(2009) Ahmad Reza Mehdipour et al.   DRUG DISCOVERY TODAY

Receptor Occupancy and Brain Free Fraction

(2009) J. Watson et al.   DRUG METABOLISM AND DISPOSITION

Unbound Brain Concentration Determines Receptor Occupancy: A Correlation of Drug Concentration and Brain Serotonin and Dopamine Reuptake Transporter Occupancy for Eighteen Compounds in Rats

(2009) X. Liu et al.   DRUG METABOLISM AND DISPOSITION

The potential for nanoparticle-based drug delivery to the brain: overcoming the blood–brain barrier

(2009) Eugen Barbu et al.   Expert Opinion on Drug Delivery

Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy

(2009) Patrick R. Verhoest et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vivo, in vitro and in silico methods for small molecule transfer across the BBB

(2009) Jurgen Mensch et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Uptake of ANG1005, A Novel Paclitaxel Derivative, Through the Blood-Brain Barrier into Brain and Experimental Brain Metastases of Breast Cancer

(2009) Fancy C. Thomas et al.   PHARMACEUTICAL RESEARCH

Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human

(2009) Mark S. Warren et al.   PHARMACOLOGICAL RESEARCH

Intracerebroventricular amyloid-  antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice

(2009) D. R. Thakker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure

(2009) Aina W Ravna et al.   Theoretical Biology and Medical Modelling

Utility of unbound plasma drug levels and P-glycoprotein transport data in prediction of central nervous system exposure

(2009) H. He et al.   XENOBIOTICA

ABCG2: A perspective

(2008) Robert W. Robey et al.   ADVANCED DRUG DELIVERY REVIEWS

Substrates and Inhibitors of Human Multidrug Resistance Associated Proteins and the Implications in Drug Development

(2008) Shu-Feng Zhou et al.   CURRENT MEDICINAL CHEMISTRY

Blood–brain barrier permeability considerations for CNS-targeted compound library design

(2008) Stephen A Hitchcock   CURRENT OPINION IN CHEMICAL BIOLOGY

Targeted Drugs and Nanomedicine: Present and Future

(2008) Paul Debbage   CURRENT PHARMACEUTICAL DESIGN

Unbound Drug Concentration in Brain Homogenate and Cerebral Spinal Fluid at Steady State as a Surrogate for Unbound Concentration in Brain Interstitial Fluid

(2008) X. Liu et al.   DRUG METABOLISM AND DISPOSITION

P-Glycoprotein Contributes to the Blood-Brain, but Not Blood-Cerebrospinal Fluid, Barrier in a Spontaneous Canine P-Glycoprotein Knockout Model

(2008) K. L. Mealey et al.   DRUG METABOLISM AND DISPOSITION

Polymeric nanoparticles for the drug delivery to the central nervous system

(2008) Giovanni Tosi et al.   Expert Opinion on Drug Delivery

Large Neutral Amino Acid Transporter Enables Brain Drug Delivery via Prodrugs

(2008) Mikko Gynther et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ultrasound Enhanced Delivery of Molecular Imaging and Therapeutic Agents in Alzheimer's Disease Mouse Models

(2008) Scott B. Raymond et al.   PLoS One

In silico prediction of brain and CSF permeation of small molecules using PLS regression models

(2007) Stefanie Bendels et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Prediction of blood–brain partitioning: A model based on ab initio calculated quantum chemical descriptors

(2007) Sofie Van Damme et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING