Inhibition of HIF-1α Reduced Blood Brain Barrier Damage by Regulating MMP-2 and VEGF During Acute Cerebral Ischemia

Hypoxia-inducible factor-1α is involved in isoflurane-induced blood-brain barrier disruption in aged rats model of POCD

(2018) Yiyun Cao et al.   BEHAVIOURAL BRAIN RESEARCH

β2-Adrenergic Receptor-Mediated HIF-1α Upregulation Mediates Blood Brain Barrier Damage in Acute Cerebral Ischemia

(2017) Yanyun Sun et al.   Frontiers in Molecular Neuroscience

Hypoxia-induced and HIF1α-VEGF-mediated tight junction dysfunction in choriocarcinoma cells: Implications for preeclampsia

(2017) Yuan Zhang et al.   CLINICA CHIMICA ACTA

Blood brain barrier breakdown was found in non-infarcted area after 2-h MCAO

(2016) Xiaona Wang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Early VEGF inhibition attenuates blood-brain barrier disruption in ischemic rat brains by regulating the expression of MMPs

(2016) Hai-Tao Zhang et al.   Molecular Medicine Reports

Normobaric Hyperoxia Extends Neuro- and Vaso-Protection of N-Acetylcysteine in Transient Focal Ischemia

(2016) Yushan Liu et al.   MOLECULAR NEUROBIOLOGY

Role of Hypoxia Inducible Factor 1 in Hyperglycemia-Exacerbated Blood-Brain Barrier Disruption in Ischemic Stroke

(2016) Ziyan Zhang et al.   NEUROBIOLOGY OF DISEASE

Pretreatment blood–brain barrier disruption and post-endovascular intracranial hemorrhage

(2016) Richard Leigh et al.   NEUROLOGY

Translational Stroke Research on Blood-Brain Barrier Damage: Challenges, Perspectives, and Goals

(2016) Yejie Shi et al.   Translational Stroke Research

Hypoxia-Induced Neuroinflammatory White-Matter Injury Reduced by Minocycline in SHR/SP

(2015) Fakhreya Y Jalal et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Activation of matrix metalloproteinase in dorsal hippocampus drives improvement in spatial working memory after intra-VTA nicotine infusion in rats

(2015) Hui Shu et al.   JOURNAL OF NEUROCHEMISTRY

Nitric Oxide Interacts with Caveolin-1 to Facilitate Autophagy-Lysosome-Mediated Claudin-5 Degradation in Oxygen-Glucose Deprivation-Treated Endothelial Cells

(2015) Jie Liu et al.   MOLECULAR NEUROBIOLOGY

Early Ischemic Blood Brain Barrier Damage: A Potential Indicator for Hemorrhagic Transformation Following Tissue Plasminogen Activator (tPA) Thrombolysis?

(2014) Xinchun Jin et al.   CURRENT NEUROVASCULAR RESEARCH

Pretreatment Blood–Brain Barrier Damage and Post-Treatment Intracranial Hemorrhage in Patients Receiving Intravenous Tissue-Type Plasminogen Activator

(2014) Richard Leigh et al.   STROKE

Hyperglycemia, Acute Ischemic Stroke, and Thrombolytic Therapy

(2014) Sherif Hafez et al.   Translational Stroke Research

VEGF Secreted by Hypoxic Muller Cells Induces MMP-2 Expression and Activity in Endothelial Cells to Promote Retinal Neovascularization in Proliferative Diabetic Retinopathy

(2013) M. Rodrigues et al.   DIABETES

Hypoxia Selectively Disrupts Brain Microvascular Endothelial Tight Junction Complexes Through a Hypoxia-Inducible Factor-1 (HIF-1) Dependent Mechanism

(2013) Sabrina Engelhardt et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Progesterone Attenuates Hemorrhagic Transformation after Delayed tPA Treatment in an Experimental Model of Stroke in Rats: Involvement of the VEGF–MMP Pathway

(2013) Soonmi Won et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ischemic neurons activate astrocytes to disrupt endothelial barrier via increasing VEGF expression

(2013) Ying-Na Li et al.   JOURNAL OF NEUROCHEMISTRY

Normobaric hyperoxia combined with minocycline provides greater neuroprotection than either alone in transient focal cerebral ischemia

(2012) Xinchun Jin et al.   EXPERIMENTAL NEUROLOGY

Matrix Metalloproteinase-2-Mediated Occludin Degradation and Caveolin-1-Mediated Claudin-5 Redistribution Contribute to Blood-Brain Barrier Damage in Early Ischemic Stroke Stage

(2012) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Spatiotemporal evolution of blood brain barrier damage and tissue infarction within the first 3h after ischemia onset

(2012) Xinchun Jin et al.   NEUROBIOLOGY OF DISEASE

Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury

(2011) Yong Gu et al.   JOURNAL OF NEUROCHEMISTRY

Differential Effects of HIF-1 Inhibition by YC-1 on the Overall Outcome and Blood-Brain Barrier Damage in a Rat Model of Ischemic Stroke

(2011) Jingqi Yan et al.   PLoS One

YC-1 attenuates hypoxia-induced pulmonary arterial hypertension in mice

(2011) Jin Won Huh et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Differential Changes of Glutathione Levels in Astrocytes and Neurons in Ischemic Brains by Two-Photon Imaging

(2010) Denis E Bragin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Suppression of hypoxia-inducible factor-1α and its downstream genes reduces acute hyperglycemia-enhanced hemorrhagic transformation in a rat model of cerebral ischemia

(2010) Chunhua Chen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Early inhibition of HIF-1α with small interfering RNA reduces ischemic–reperfused brain injury in rats

(2009) Chunhua Chen et al.   NEUROBIOLOGY OF DISEASE

VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown

(2009) Azeb Tadesse Argaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte responses to injury: VEGF simultaneously modulates cell death and proliferation

(2008) Nicole Schmid-Brunclik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke

(2008) Werner Hacke et al.   NEW ENGLAND JOURNAL OF MEDICINE