Normobaric Hyperoxia Extends Neuro- and Vaso-Protection of N-Acetylcysteine in Transient Focal Ischemia

Blood brain barrier breakdown was found in non-infarcted area after 2-h MCAO

(2016) Xiaona Wang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Normobaric Hyperoxia Slows Blood-Brain Barrier Damage and Expands the Therapeutic Time Window for Tissue-Type Plasminogen Activator Treatment in Cerebral Ischemia

(2015) J. Liang et al.   STROKE

Early Ischemic Blood Brain Barrier Damage: A Potential Indicator for Hemorrhagic Transformation Following Tissue Plasminogen Activator (tPA) Thrombolysis?

(2014) Xinchun Jin et al.   CURRENT NEUROVASCULAR RESEARCH

Chelating Intracellularly Accumulated Zinc Decreased Ischemic Brain Injury Through Reducing Neuronal Apoptotic Death

(2014) Yongmei Zhao et al.   STROKE

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Reduced apoptosis by combining normobaric oxygenation with ethanol in transient ischemic stroke

(2013) Xiaokun Geng et al.   BRAIN RESEARCH

Hypoxia-inducible factor 1 contributes to N-acetylcysteine’s protection in stroke

(2013) Ziyan Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Antioxidant N-Acetylcysteine Prevents HIF-1 Stabilization under Hypoxia In Vitro but Does Not Affect Tumorigenesis in Multiple Breast Cancer Models In Vivo

(2013) Jaclyn Sceneay et al.   PLoS One

Synergetic Neuroprotection of Normobaric Oxygenation and Ethanol in Ischemic Stroke Through Improved Oxidative Mechanism

(2013) Xiaokun Geng et al.   STROKE

Normobaric hyperoxia combined with minocycline provides greater neuroprotection than either alone in transient focal cerebral ischemia

(2012) Xinchun Jin et al.   EXPERIMENTAL NEUROLOGY

Acute carbonyl stress induces occludin glycation and brain microvascular endothelial barrier dysfunction: Role for glutathione-dependent metabolism of methylglyoxal

(2012) Wei Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Evaluation of Combination Therapy in Animal Models of Cerebral Ischemia

(2012) Victoria E O'Collins et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Matrix Metalloproteinase-2-Mediated Occludin Degradation and Caveolin-1-Mediated Claudin-5 Redistribution Contribute to Blood-Brain Barrier Damage in Early Ischemic Stroke Stage

(2012) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Spatiotemporal evolution of blood brain barrier damage and tissue infarction within the first 3h after ischemia onset

(2012) Xinchun Jin et al.   NEUROBIOLOGY OF DISEASE

The neurovascular unit and combination treatment strategies for stroke

(2012) Li Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Up-regulation of caveolin-1 and blood–brain barrier breakdown are attenuated by N-acetylcysteine in thiamine deficiency

(2010) Élizabeth Beauchesne et al.   NEUROCHEMISTRY INTERNATIONAL

Targeting the Ischemic Penumbra

(2010) P. Ramos-Cabrer et al.   STROKE

Increased intranuclear matrix metalloproteinase activity in neurons interferes with oxidative DNA repair in focal cerebral ischemia

(2009) Yi Yang et al.   JOURNAL OF NEUROCHEMISTRY

Combination Treatment with Normobaric Hyperoxia and Cilostazol Protects Mice against Focal Cerebral Ischemia-Induced Neuronal Damage Better Than Each Treatment Alone

(2009) Y. Nonaka et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Early inhibition of HIF-1α with small interfering RNA reduces ischemic–reperfused brain injury in rats

(2009) Chunhua Chen et al.   NEUROBIOLOGY OF DISEASE

VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown

(2009) Azeb Tadesse Argaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normobaric hyperoxia attenuates early blood-brain barrier disruption by inhibiting MMP-9-mediated occludin degradation in focal cerebral ischemia

(2008) Wenlan Liu et al.   JOURNAL OF NEUROCHEMISTRY

Combination effects of normobaric hyperoxia and edaravone on focal cerebral ischemia-induced neuronal damage in mice

(2008) Yuko Nonaka et al.   NEUROSCIENCE LETTERS