Interplay between Cellular Metabolism and Cytokine Responses during Viral Infection

Metabolic reprogramming of host cells upon bacterial infection: Why shift to a Warburg-like metabolism?

(2018) Pedro Escoll et al.   FEBS Journal

Regulation of the Immune Response by the Aryl Hydrocarbon Receptor

(2018) Cristina Gutiérrez-Vázquez et al.   IMMUNITY

Interleukin 4 affects lipid metabolism and the expression of pro-inflammatory factors in mature rat adipocytes

(2018) Dawid Szczepankiewicz et al.   IMMUNOBIOLOGY

The essential role of mitochondrial dynamics in antiviral immunity

(2018) Seong-Jun Kim et al.   MITOCHONDRION

Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity

(2018) Wooseong Lee et al.   Nature Communications

Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice

(2018) Nick D. Van Skike et al.   PLoS Pathogens

Interkingdom microbial consortia mechanisms to guide biotechnological applications

(2018) Shu Zhang et al.   Microbial Biotechnology

Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication

(2018) Junjie Zhang et al.   Cell Host & Microbe

Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose

(2018) Ping Zhou et al.   NATURE

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

(2018) Monika Bambouskova et al.   NATURE

IL-10 prevents aging-associated inflammation and insulin resistance in skeletal muscle

(2017) Sezin Dagdeviren et al.   FASEB JOURNAL

Glutamine supplementation suppresses herpes simplex virus reactivation

(2017) Kening Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

PPAR-delta modulates membrane cholesterol and cytokine signaling in malignant B cells

(2017) L Sun et al.   LEUKEMIA

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Effects of glutamine, taurine and their association on inflammatory pathway markers in macrophages

(2017) Talita Sartori et al.   INFLAMMOPHARMACOLOGY

RLR-mediated antiviral innate immunity requires oxidative phosphorylation activity

(2017) Takuma Yoshizumi et al.   Scientific Reports

Antiviral activity of various interferons and pro-inflammatory cytokines in non-transformed cultured hepatocytes infected with hepatitis B virus

(2016) Nathalie Isorce et al.   ANTIVIRAL RESEARCH

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation

(2016) Jun Zhao et al.   Cell Host & Microbe

Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses

(2016) Laurent Chatel-Chaix et al.   Cell Host & Microbe

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Bacterial membrane vesicles: Biogenesis, immune regulation and pathogenesis

(2016) Rishi D. Pathirana et al.   CELLULAR MICROBIOLOGY

Current topics in HIV pathogenesis, part 2: Inflammation drives a Warburg-like effect on the metabolism of HIV-infected subjects

(2016) Mouna Aounallah et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The role of AHR-inducible cytochrome P450s in metabolism of polyunsaturated fatty acids

(2016) Oliver Hankinson   DRUG METABOLISM REVIEWS

Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function

(2016) Duojiao Wu et al.   IMMUNITY

MicroRNAs Regulate Cytokine Responses in Gingival Epithelial Cells

(2016) Steven C. Y. Chen et al.   INFECTION AND IMMUNITY

Emerging Roles of Protein Deamidation in Innate Immune Signaling

(2016) Jun Zhao et al.   JOURNAL OF VIROLOGY

The microbiome and innate immunity

(2016) Christoph A. Thaiss et al.   NATURE

Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling

(2016) C. Rutherford et al.   Science Signaling

Activation of cellular metabolism during latent Kaposi's Sarcoma herpesvirus infection

(2016) Michael Lagunoff   Current Opinion in Virology

Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling

(2016) C. Rutherford et al.   Science Signaling

The Roles of mTOR Complexes in Lipid Metabolism

(2015) Alexandre Caron et al.   Annual Review of Nutrition

How Low Cholesterol Is Good for Anti-viral Immunity

(2015) Luke A.J. O’Neill   CELL

Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling

(2015) Autumn G. York et al.   CELL

Beyond Energy Homeostasis: the Expanding Role of AMP-Activated Protein Kinase in Regulating Metabolism

(2015) David Carling et al.   Cell Metabolism

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells

(2015) John P. Ray et al.   IMMUNITY

Mitochondria in the Regulation of Innate and Adaptive Immunity

(2015) Samuel E. Weinberg et al.   IMMUNITY

Immunometabolism: Cellular Metabolism Turns Immune Regulator

(2015) Róisín M. Loftus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interference with Virus Infection

(2015) Michael Gale   JOURNAL OF IMMUNOLOGY

Viral Pseudo-Enzymes Activate RIG-I via Deamidation to Evade Cytokine Production

(2015) Shanping He et al.   MOLECULAR CELL

Autophagy and autophagy-related proteins in the immune system

(2015) Shusaku T Shibutani et al.   NATURE IMMUNOLOGY

Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation

(2015) Xiaodi Su et al.   NATURE IMMUNOLOGY

Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity

(2015) R. G. Gaudet et al.   SCIENCE

Stealing the Keys to the Kitchen: Viral Manipulation of the Host Cell Metabolic Network

(2015) Christopher M. Goodwin et al.   TRENDS IN MICROBIOLOGY

Viral activation of cellular metabolism

(2015) Erica L. Sanchez et al.   VIROLOGY

Innate immune recognition of DNA: A recent history

(2015) Alan Dempsey et al.   VIROLOGY

Recent advances on viral manipulation of NF-κB signaling pathway

(2015) Jun Zhao et al.   Current Opinion in Virology

How RIG-I like receptors activate MAVS

(2015) Bin Wu et al.   Current Opinion in Virology

Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease

(2014) Mark D. Turner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The interplay between central metabolism and innate immune responses

(2014) Shih-Chin Cheng et al.   CYTOKINE & GROWTH FACTOR REVIEWS

New insights into the role of the aryl hydrocarbon receptor in the function of CD11c+cells during respiratory viral infection

(2014) Guang-Bi Jin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Roles of Lysosomes in Inflammation and Autoimmune Diseases

(2014) Wei Ge et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Dengue Virus Induces and Requires Glycolysis for Optimal Replication

(2014) Krystal A. Fontaine et al.   JOURNAL OF VIROLOGY

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

(2014) Jan Mauer et al.   NATURE IMMUNOLOGY

Hepatitis C virus triggers mitochondrial fission and attenuates apoptosis to promote viral persistence

(2014) S.-J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity

(2014) Takuma Yoshizumi et al.   Nature Communications

Kaposi's Sarcoma Associated Herpesvirus Tegument Protein ORF75 Is Essential for Viral Lytic Replication and Plays a Critical Role in the Antagonization of ND10-Instituted Intrinsic Immunity

(2014) Florian Full et al.   PLoS Pathogens

Kaposi's Sarcoma Herpesvirus MicroRNAs Induce Metabolic Transformation of Infected Cells

(2014) Ohad Yogev et al.   PLoS Pathogens

Cyclic Dinucleotides and the Innate Immune Response

(2013) Olga Danilchanka et al.   CELL

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

AMPKα1 Regulates Macrophage Skewing at the Time of Resolution of Inflammation during Skeletal Muscle Regeneration

(2013) Rémi Mounier et al.   Cell Metabolism

Foam cells in atherosclerosis

(2013) Xiao-Hua Yu et al.   CLINICA CHIMICA ACTA

Cytokine synergy: An underappreciated contributor to innate anti-viral immunity

(2013) Eric Bartee et al.   CYTOKINE

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation

(2013) M. E. Heid et al.   JOURNAL OF IMMUNOLOGY

Interleukin-4 regulates lipid metabolism by inhibiting adipogenesis and promoting lipolysis

(2013) Chang-Hui Tsao et al.   JOURNAL OF LIPID RESEARCH

Role of proinflammatory cytokines on expression of vitamin D metabolism and target genes in colon cancer cells

(2013) Doris M. Hummel et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Fatty acid–induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis

(2013) Stefan Freigang et al.   NATURE IMMUNOLOGY

Tumor necrosis factor alpha increases aerobic glycolysis and reduces oxidative metabolism in prostate epithelial cells

(2013) Roger A. Vaughan et al.   PROSTATE

Control of Cellular Bcl-xL Levels by Deamidation-Regulated Degradation

(2013) So Hee Dho et al.   PLOS BIOLOGY

COX5B Regulates MAVS-mediated Antiviral Signaling through Interaction with ATG5 and Repressing ROS Production

(2013) Yuanyuan Zhao et al.   PLoS Pathogens

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

(2012) Alfredo Castello et al.   CELL

The Nucleotide Synthesis Enzyme CAD Inhibits NOD2 Antibacterial Function in Human Intestinal Epithelial Cells

(2012) Amy L. Richmond et al.   GASTROENTEROLOGY

Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol

(2012) Su-Yang Liu et al.   IMMUNITY

Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon by Binding to MAVS and Decreasing Mitochondrial Membrane Potential

(2012) Zsuzsanna T. Varga et al.   JOURNAL OF VIROLOGY

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

The mitochondrial citrate carrier: a new player in inflammation

(2011) Vittoria Infantino et al.   BIOCHEMICAL JOURNAL

Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice

(2011) Shigeki Nakamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Nitric Oxide-Induced Activation of the AMP-Activated Protein Kinase α2 Subunit Attenuates IκB Kinase Activity and Inflammatory Responses in Endothelial Cells

(2011) Elke Bess et al.   PLoS One

Viral effects on metabolism: changes in glucose and glutamine utilization during human cytomegalovirus infection

(2011) Yongjun Yu et al.   TRENDS IN MICROBIOLOGY

Inflammatory Cytokine Response to Bacillus anthracis Peptidoglycan Requires Phagocytosis and Lysosomal Trafficking

(2010) J. K. Iyer et al.   INFECTION AND IMMUNITY

Culprits with evolutionary ties

(2010) Carolyn S. Calfee et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Fatty acids alter glycerolipid metabolism and induce lipid droplet formation, syncytialisation and cytokine production in human trophoblasts with minimal glucose effect or interaction

(2010) A.N. Pathmaperuma et al.   PLACENTA

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

miRNA regulation of cytokine genes

(2009) Ananthi J. Asirvatham et al.   CYTOKINE

Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway

(2009) Céline Castanier et al.   EMBO REPORTS

A Systems Biology Approach To Identify the Combination Effects of Human Herpesvirus 8 Genes on NF- B Activation

(2009) A. Konrad et al.   JOURNAL OF VIROLOGY

Glutamine Metabolism Is Essential for Human Cytomegalovirus Infection

(2009) J. W. Chambers et al.   JOURNAL OF VIROLOGY

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

(2009) Michal Caspi Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling

(2009) K. Yasukawa et al.   Science Signaling

Glutamine supplementation increases Th1-cytokine responses in murine intestinal intraepithelial lymphocytes

(2008) Yoshiaki Horio et al.   CYTOKINE

Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle

(2008) I. Nieto-Vazquez et al.   DIABETES

Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells

(2008) Frank Schmitz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE