Review
Immunology
Megumi Kurosawa, Masayuki Sekine, Manako Yamaguchi, Risa Kudo, Sharon J. B. Hanley, Megumi Hara, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Sayaka Ikeda, Asami Yagi, Takayuki Enomoto
Summary: The preventive effect of HPV vaccines against anogenital and oropharyngeal cancers has been proven in both clinical trials and real-world data, with different durations of effectiveness for different vaccines. The 4-valent vaccine has shown the longest sustained clinical effect, while further observation is needed for the 9-valent vaccine.
Article
Immunology
Ikponmwosa Osaghae, Charles Darkoh, Onyema Greg Chido-Amajuoyi, Wenyaw Chan, Paige Padgett Wermuth, Mala Pande, Sonia A. Cunningham, Sanjay Shete
Summary: This study aimed to determine the association between healthcare providers' self-efficacy in HPV vaccination hesitancy counseling and HPV vaccination acceptance. The results showed that healthcare providers with higher self-efficacy observed higher HPV vaccination acceptance after initial and follow-up counseling sessions. Therefore, healthcare providers should receive training in HPV vaccination counseling and utilize every visit to counsel hesitant patients.
Article
Immunology
Yang Xing, Feroza Yasinjan, Yajie Du, Huayue Geng, Ying Zhang, Minghua He, Rui Guo, Lei Yang, Jiayue Cui, Dongmei Mu, Ziling Liu, Hong Wang
Summary: Cervical cancer is a major global health issue, with limited treatment options for advanced cases. Immunotherapy has emerged as a promising approach for these patients and has shown significant progress in recent years.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
David Robert Grimes, Edward M. A. Corry, Talia Malagon, Ciaran O'Riain, Eduardo L. Franco, Donal J. Brennan
Summary: The study compared different cervical cancer screening modalities on a simulated population of women aged >= 25 years, considering the increasing uptake of the HPV vaccine. HPV-based modalities outperformed LBC-based approaches, with reflex approaches and appropriate test intervals maximizing therapeutic efficacy. Increasing HPV vaccination rates resulted in fewer unnecessary colposcopies with HPV-based screening approaches.
Article
Immunology
Katarzyna Smolarczyk, Anna Duszewska, Slawomir Drozd, Slawomir Majewski
Summary: The study reveals that parents in Poland have low knowledge about HPV and HPV vaccines, with only 49.4% providing correct answers. Parents' attitudes are influenced solely by knowledge and education.
Review
Immunology
Ayazhan Akhatova, Azliyati Azizan, Kuralay Atageldiyeva, Aiymkul Ashimkhanova, Aizada Marat, Yerbolat Iztleuov, Assem Suleimenova, Saikal Shamkeeva, Gulzhanat Aimagambetova
Summary: Immunization is a highly successful method for preventing infectious diseases, including HPV infection. Multiple HPV vaccines have been developed and proven to be effective and safe. However, concerns and negative perceptions have hindered the implementation of HPV vaccination campaigns in some countries. Therefore, it is important to promote health education interventions to increase acceptance of HPV vaccines.
Article
Engineering, Multidisciplinary
Fernando Saldana, Jose A. Camacho-Gutierrez, Geiser Villavicencio-Pulido, Jorge X. Velasco-Hernandez
Summary: HPV vaccines have shown positive results in reducing HPV infection and related diseases. This study presents a mathematical model to assess the impact of HPV immunization programs and determine the optimal deployment strategy for vaccination. The findings suggest that girls-only programs complemented with catch-up vaccination for adult females can achieve HPV-associated cancers eradication. The optimal vaccine deployment is to allocate more vaccines in the initial phase of the epidemic and then gradually decrease vaccination rates.
APPLIED MATHEMATICAL MODELLING
(2022)
Review
Gastroenterology & Hepatology
Paul Y. Kwo, Tushar Patel
Summary: Clinical trials are crucial for advancing new therapies for liver diseases and adapting to emerging capabilities and external forces. The COVID-19 pandemic has prompted changes in clinical trial operations and opportunities for innovation in hepatology trials. Technological advances will drive future trials, incorporating digital capabilities and expanded data collection, computing, and analytics. Innovative trial designs and broader participant engagement will shape trial conduct, along with evolving regulatory needs and new stakeholders. The evolution of clinical trials presents unique opportunities to improve the lives of patients with liver diseases.
Review
Medicine, General & Internal
Ojone Illah, Adeola Olaitan
Summary: Cervical cancer remains a significant global challenge, but developed countries have made progress with structured screening programs and HPV vaccination. In a few decades, countries with national HPV vaccination programs are on track for cervical cancer elimination. However, developing countries without these programs still face high rates of morbidity and mortality from cervical cancer. Increasing global HPV vaccine coverage and uptake is crucial for addressing the unequal distribution of cervical cancer incidence.
Article
Public, Environmental & Occupational Health
Ilkka Kalliala, Tiina Eriksson, Karoliina Aro, Mari Hokkanen, Matti Lehtinen, Mika Gissler, Pekka Nieminen
Summary: The study found that the rates of preterm birth, especially early preterm birth, were lower among women who received HPV vaccination, indicating that prophylactic HPV vaccination may help reduce preterm birth rates.
PREVENTIVE MEDICINE
(2021)
Review
Immunology
Mahdi Kohansal Vajari, Mohammad-Javad Sanaei, Sina Salari, Alireza Rezvani, Mehrnaz Sadat Ravari, Davood Bashash
Summary: Breast cancer is a challenging malignancy due to its heterogeneity, tumor resistance, metastasis, and recurrence. Cancer immunotherapy, including therapeutic cancer vaccination, holds great promise for the treatment of breast cancer. However, the application of cancer vaccines in breast cancer as monotherapy has not been satisfying in inducing anti-tumor immunity. Combination therapies and different vaccine platforms could influence the clinical benefits of breast cancer treatment. Majority of breast cancer vaccine trials are in phase I and II, indicating the need for further development and favorable outcomes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Caitlin Swift, Aditi Dey, Harunor Rashid, Katrina Clark, Ramesh Manocha, Julia Brotherton, Frank Beard
Summary: Australia has been a leader in HPV vaccination, implementing a national program since 2007. The program has recently transitioned to a 2-dose schedule and has been well accepted by schools and students, reducing costs and resource requirements. However, completion rates have not increased as anticipated due to dosing intervals and limited opportunities for catch-up vaccination. Vaccine hesitancy is not currently a major issue but remains a potential threat. Measures to optimize the program's impact and address potential barriers are important.
Article
Immunology
Lara Colome-Ceballos, Josep Lluis Clua-Espuny, Concepcion Ceballos-Garcia, Josep Clua-Queralt, Maria Jesus Pla-Farnos, Jose Fernandez-Saez
Summary: This study aims to identify independent prognostic factors that affect HPV vaccination in a rural community, specifically related to sexual and reproductive health. Age and immigrant origin were found to be barriers to HPV vaccination, while HPV PCR was found to be a facilitating factor.
Article
Immunology
Gulzhanat Aimagambetova, Aisha Babi, Torgyn Issa, Alpamys Issanov
Summary: The study found that Kazakhstani women have contrasting attitudes towards the HPV vaccine, with approximately half having positive attitudes and almost half having negative or neutral attitudes. Women with low education levels, high number of children, belief in alternative medicine, and impacted by the failed vaccination program in 2013 are less likely to have a positive attitude towards the vaccine.
Article
Immunology
Beth Sundstrom, Kathleen B. Cartmell, Ashley A. White, Henry Well, Jennifer Young Pierce, Heather M. Brandt
Summary: A social media campaign in South Carolina aimed to increase parental awareness and build confidence around HPV vaccination. The campaign, conducted over ten weeks, resulted in strong engagement on Facebook and Twitter, reaching a significant number of individuals and garnering over 1000 followers.
Article
Oncology
Sarah Dilley, Britt K. Erickson, Caroline E. Phillips, Caroline R. Kennemer, Bin Zhang, Tasnia Matin, Jovana Y. Martin, Monjri S. Shah, J. Michael Straughn, Charles A. Leath
GYNECOLOGIC ONCOLOGY
(2018)
Article
Obstetrics & Gynecology
Akila Subramaniam, Christina T. Blanchard, Britt K. Erickson, Jeff Szychowski, Charles A. Leath, Joseph R. Biggio, Warner K. Huh
OBSTETRICS AND GYNECOLOGY
(2018)
Article
Immunology
Abigail M. Schnaith, Erica M. Evans, Caleb Vogt, Andrea M. Tinsay, Thomas E. Schmidt, Katelyn M. Tessier, Britt K. Erickson
Article
Oncology
Anne R. Van Arsdale, Rebecca C. Arend, Maria J. Cossio, Britt K. Erickson, Yanhua Wang, David W. Doo, Charles A. Leath, Gary L. Goldberg, Gloria S. Huang
Article
Obstetrics & Gynecology
Alexandra M. Schefter, John Fischer, Britt K. Erickson
FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY
(2018)
Article
Oncology
Camille C. Gunderson, Britt K. Erickson, Ivy Wilkinson-Ryan, Sara K. Vesely, Charles A. Leath, Paola A. Gehrig, Kathleen N. Moore
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2019)
Article
Oncology
Akila Subramaniam, Brett D. Einerson, Christina T. Blanchard, Britt K. Erickson, Jeff Szychowski, Charles A. Leath, Joseph R. Biggio, Warner K. Huh
GYNECOLOGIC ONCOLOGY
(2019)
Article
Oncology
Sabrina M. Bedell, Chloe Hedberg, Anna Griffin, Hannah Pearson, Annelise Wilhite, Nathan Rubin, Britt K. Erickson
GYNECOLOGIC ONCOLOGY
(2019)
Article
Obstetrics & Gynecology
Annelise M. Wilhite, Makinna C. Oestreich, Megan Olson, Sabrina M. Bedell, Danielle Westenberg, Ananta Bangdiwala, Salman Ikramuddin, Monica Sanchez-Avila, Robert D. Madoff, Mahmoud A. Khalifa, Britt K. Erickson
OBSTETRICS AND GYNECOLOGY
(2019)
Article
Oncology
Artur A. Serebrenik, Prokopios P. Argyris, Matthew C. Jarvis, William L. Brown, Martina Bazzaro, Rachel I. Vogel, Britt K. Erickson, Sun-Hee Lee, Krista M. Goergen, Matthew J. Maurer, Ethan P. Heinzen, Ann L. Oberg, Yajue Huang, Xiaonan Hou, S. John Weroha, Scott H. Kaufmann, Reuben S. Harris
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Valentino Clemente, Asumi Hoshino, Mihir Shetty, Andrew Nelson, Britt K. Erickson, Ruth Baker, Nathan Rubin, Mahmoud Khalifa, S. John Weroha, Emil Lou, Martina Bazzaro
Summary: Targeting glutamine metabolism has been proposed as a therapeutic strategy for ovarian cancer, and the kidney isoform of glutaminase, GLS1, has emerged as a potential target. CB839, a first-in-class GLS1 inhibitor, has shown promise in clinical trials and is being investigated in platinum-resistant ovarian cancer patients. In OCCC, the presence of ARID1A mutations has been suggested to drive GLS1 expression and metabolism reprogramming. However, our study found that GLS1 overexpression was not correlated with ARID1A loss in clinical specimens of OCCC, and was associated with better clinical outcomes. This suggests that blockade of GLS1 may not be beneficial for OCCC patients.
CANCER RESEARCH COMMUNICATIONS
(2022)
Article
Obstetrics & Gynecology
Jennifer Hagen, Annelise Wilhite, Maryna Tarbunova, Britt Erickson
GYNECOLOGIC ONCOLOGY REPORTS
(2019)
Article
Obstetrics & Gynecology
Emily M. Hartsougha, Britt K. Erickson, Anil Chauhan, Mahmoud A. Khalifa
GYNECOLOGIC ONCOLOGY REPORTS
(2019)
Article
Obstetrics & Gynecology
Khalid Amin, Beatrice Brumley, Britt K. Erickson, Mahmoud A. Khalifa
GYNECOLOGIC ONCOLOGY REPORTS
(2018)
Article
Obstetrics & Gynecology
Laura R. Daily, Britt K. Erickson, Daniel N. Pasko, J. Michael Straughn, Warner K. Huh, Charles A. Leath
JOURNAL OF LOWER GENITAL TRACT DISEASE
(2018)