Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life

Preliminary Study of Two Antiviral Agents for Hepatitis C Genotype 1

(2012) Anna S. Lok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Second-phase hepatitis C virus RNA decline during telaprevir-based therapy increases with drug effectiveness: Implications for treatment duration

(2011) Jeremie Guedj et al.   HEPATOLOGY

Hepatitis C viral kinetics with the nucleoside polymerase inhibitor mericitabine (RG7128)

(2011) Jeremie Guedj et al.   HEPATOLOGY

Small Molecules Targeting Hepatitis C Virus-Encoded NS5A Cause Subcellular Redistribution of Their Target: Insights into Compound Modes of Action

(2011) P. Targett-Adams et al.   JOURNAL OF VIROLOGY

A Comprehensive Hepatitis C Viral Kinetic Model Explaining Cure

(2010) E Snoeck et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Protease Inhibitor–Resistant Hepatitis C Virus Mutants With Reduced Fitness From Impaired Production of Infectious Virus

(2010) Tetsuro Shimakami et al.   GASTROENTEROLOGY

All Three Domains of the Hepatitis C Virus Nonstructural NS5A Protein Contribute to RNA Binding

(2010) T. L. Foster et al.   JOURNAL OF VIROLOGY

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

(2010) Min Gao et al.   NATURE

Domain III of NS5A contributes to both RNA replication and assembly of hepatitis C virus particles

(2009) M. Hughes et al.   JOURNAL OF GENERAL VIROLOGY

Modeling Subgenomic Hepatitis C Virus RNA Kinetics during Treatment with Alpha Interferon

(2009) H. Dahari et al.   JOURNAL OF VIROLOGY

Interaction of Hepatitis C Virus Nonstructural Protein 5A with Core Protein Is Critical for the Production of Infectious Virus Particles

(2008) T. Masaki et al.   JOURNAL OF VIROLOGY

Essential Role of Domain III of Nonstructural Protein 5A for Hepatitis C Virus Infectious Particle Assembly

(2008) Nicole Appel et al.   PLoS Pathogens

Regulation of Hepatitis C Virion Production via Phosphorylation of the NS5A Protein

(2008) Timothy L. Tellinghuisen et al.   PLoS Pathogens