The Parkinson’s Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway
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Title
The Parkinson’s Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway
Authors
Keywords
Notch signaling, Neurons, Dopaminergics, Drosophila melanogaster, Immunoprecipitation, RNA interference, Neuronal differentiation, Parkinson disease
Journal
PLoS Genetics
Volume 11, Issue 9, Pages e1005503
Publisher
Public Library of Science (PLoS)
Online
2015-09-11
DOI
10.1371/journal.pgen.1005503
References
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Note: Only part of the references are listed.- Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy
- (2014) Eszter Zavodszky et al. Nature Communications
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- (2014) Kahori Shiba-Fukushima et al. PLoS Genetics
- Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering
- (2014) Kahori Shiba-Fukushima et al. PLoS Genetics
- RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk
- (2013) David A. MacLeod et al. NEURON
- Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres
- (2012) Ji Li et al. EMBO REPORTS
- GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2
- (2012) A. Biosa et al. HUMAN MOLECULAR GENETICS
- Identification and Proteomic Analysis of Distinct UBE3A/E6AP Protein Complexes
- (2012) G. Martinez-Noel et al. MOLECULAR AND CELLULAR BIOLOGY
- The Nitric Oxide-Cyclic GMP Pathway Regulates FoxO and Alters Dopaminergic Neuron Survival in Drosophila
- (2012) Tomoko Kanao et al. PLoS One
- Notch Signaling Activates Yorkie Non-Cell Autonomously in Drosophila
- (2012) Hillary K. Graves et al. PLoS One
- PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy
- (2012) Kahori Shiba-Fukushima et al. Scientific Reports
- A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease
- (2011) Alexander Zimprich et al. AMERICAN JOURNAL OF HUMAN GENETICS
- VPS35 Mutations in Parkinson Disease
- (2011) Carles Vilariño-Güell et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Mechanism and Significance of cis-Inhibition in Notch Signalling
- (2011) David del Álamo et al. CURRENT BIOLOGY
- LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice
- (2011) Martin C. Herzig et al. HUMAN MOLECULAR GENETICS
- Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning
- (2011) M. W. Dodson et al. HUMAN MOLECULAR GENETICS
- Distinct intracellular motifs of Delta mediate its ubiquitylation and activation by Mindbomb1 and Neuralized
- (2011) Aikaterini Daskalaki et al. JOURNAL OF CELL BIOLOGY
- Not(ch) just development: Notch signalling in the adult brain
- (2011) Jessica L. Ables et al. NATURE REVIEWS NEUROSCIENCE
- Activity-Induced Notch Signaling in Neurons Requires Arc/Arg3.1 and Is Essential for Synaptic Plasticity in Hippocampal Networks
- (2011) Lavinia Alberi et al. NEURON
- DSL-Notch Signaling in the Drosophila Brain in Response to Olfactory Stimulation
- (2011) Toby Lieber et al. NEURON
- Genetic Manipulation of Genes and Cells in the Nervous System of the Fruit Fly
- (2011) Koen J.T. Venken et al. NEURON
- Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor
- (2011) Hiroshi Hanafusa et al. Nature Communications
- The cell giveth and the cell taketh away: An overview of Notch pathway activation by endocytic trafficking of ligands and receptors
- (2010) Emily B. Pratt et al. ACTA HISTOCHEMICA
- Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila
- (2010) Tomoko Kanao et al. HUMAN MOLECULAR GENETICS
- Expression of leucine-rich-repeat-kinase 2 (LRRK2) during embryonic development
- (2010) Sabrina Zechel et al. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
- Presenilin 1 Mutants Impair the Self-Renewal and Differentiation of Adult Murine Subventricular Zone-Neuronal Progenitors via Cell-Autonomous Mechanisms Involving Notch Signaling
- (2010) K. Veeraraghavalu et al. JOURNAL OF NEUROSCIENCE
- Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice
- (2010) B. Winner et al. NEUROBIOLOGY OF DISEASE
- Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of -synuclein, and apoptotic cell death in aged mice
- (2010) Y. Tong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- GTPase Activity Plays a Key Role in the Pathobiology of LRRK2
- (2010) Yulan Xiong et al. PLoS Genetics
- Neurogenesis and Alzheimer's disease: At the crossroads
- (2009) Orly Lazarov et al. EXPERIMENTAL NEUROLOGY
- Leucine-rich repeat kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease
- (2009) K. Venderova et al. HUMAN MOLECULAR GENETICS
- Dependence of Leucine-rich Repeat Kinase 2 (LRRK2) Kinase Activity on Dimerization
- (2009) Saurabh Sen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Unexpected Lack of Hypersensitivity in LRRK2 Knock-Out Mice to MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine)
- (2009) E. Andres-Mateos et al. JOURNAL OF NEUROSCIENCE
- Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi
- (2009) Jennifer L. Mummery-Widmer et al. NATURE
- Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
- (2009) Wataru Satake et al. NATURE GENETICS
- Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein
- (2009) Xian Lin et al. NEURON
- PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
- (2009) C. Vives-Bauza et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Drosophila HOPS and AP-3 Complex Genes Are Required for a Deltex-Regulated Activation of Notch in the Endosomal Trafficking Pathway
- (2008) Marian Wilkin et al. DEVELOPMENTAL CELL
- Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
- (2008) Yuzuru Imai et al. EMBO JOURNAL
- The Roco protein family: a functional perspective
- (2008) Ignacio Marín et al. FASEB JOURNAL
- The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation
- (2008) Elisa Greggio et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- -Synuclein Alters Notch-1 Expression and Neurogenesis in Mouse Embryonic Stem Cells and in the Hippocampus of Transgenic Mice
- (2008) L. Crews et al. JOURNAL OF NEUROSCIENCE
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