The Parkinson’s Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway

Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy

(2014) Eszter Zavodszky et al.   Nature Communications

PINK1-Mediated Phosphorylation of Parkin Boosts Parkin Activity in Drosophila

(2014) Kahori Shiba-Fukushima et al.   PLoS Genetics

Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering

(2014) Kahori Shiba-Fukushima et al.   PLoS Genetics

RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk

(2013) David A. MacLeod et al.   NEURON

Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres

(2012) Ji Li et al.   EMBO REPORTS

GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2

(2012) A. Biosa et al.   HUMAN MOLECULAR GENETICS

Identification and Proteomic Analysis of Distinct UBE3A/E6AP Protein Complexes

(2012) G. Martinez-Noel et al.   MOLECULAR AND CELLULAR BIOLOGY

The Nitric Oxide-Cyclic GMP Pathway Regulates FoxO and Alters Dopaminergic Neuron Survival in Drosophila

(2012) Tomoko Kanao et al.   PLoS One

Notch Signaling Activates Yorkie Non-Cell Autonomously in Drosophila

(2012) Hillary K. Graves et al.   PLoS One

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

(2012) Kahori Shiba-Fukushima et al.   Scientific Reports

A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease

(2011) Alexander Zimprich et al.   AMERICAN JOURNAL OF HUMAN GENETICS

VPS35 Mutations in Parkinson Disease

(2011) Carles Vilariño-Güell et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mechanism and Significance of cis-Inhibition in Notch Signalling

(2011) David del Álamo et al.   CURRENT BIOLOGY

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

(2011) Martin C. Herzig et al.   HUMAN MOLECULAR GENETICS

Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning

(2011) M. W. Dodson et al.   HUMAN MOLECULAR GENETICS

Distinct intracellular motifs of Delta mediate its ubiquitylation and activation by Mindbomb1 and Neuralized

(2011) Aikaterini Daskalaki et al.   JOURNAL OF CELL BIOLOGY

Not(ch) just development: Notch signalling in the adult brain

(2011) Jessica L. Ables et al.   NATURE REVIEWS NEUROSCIENCE

Activity-Induced Notch Signaling in Neurons Requires Arc/Arg3.1 and Is Essential for Synaptic Plasticity in Hippocampal Networks

(2011) Lavinia Alberi et al.   NEURON

DSL-Notch Signaling in the Drosophila Brain in Response to Olfactory Stimulation

(2011) Toby Lieber et al.   NEURON

Genetic Manipulation of Genes and Cells in the Nervous System of the Fruit Fly

(2011) Koen J.T. Venken et al.   NEURON

Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor

(2011) Hiroshi Hanafusa et al.   Nature Communications

The cell giveth and the cell taketh away: An overview of Notch pathway activation by endocytic trafficking of ligands and receptors

(2010) Emily B. Pratt et al.   ACTA HISTOCHEMICA

Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila

(2010) Tomoko Kanao et al.   HUMAN MOLECULAR GENETICS

Expression of leucine-rich-repeat-kinase 2 (LRRK2) during embryonic development

(2010) Sabrina Zechel et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Presenilin 1 Mutants Impair the Self-Renewal and Differentiation of Adult Murine Subventricular Zone-Neuronal Progenitors via Cell-Autonomous Mechanisms Involving Notch Signaling

(2010) K. Veeraraghavalu et al.   JOURNAL OF NEUROSCIENCE

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

(2010) B. Winner et al.   NEUROBIOLOGY OF DISEASE

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of  -synuclein, and apoptotic cell death in aged mice

(2010) Y. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GTPase Activity Plays a Key Role in the Pathobiology of LRRK2

(2010) Yulan Xiong et al.   PLoS Genetics

Neurogenesis and Alzheimer's disease: At the crossroads

(2009) Orly Lazarov et al.   EXPERIMENTAL NEUROLOGY

Leucine-rich repeat kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

(2009) K. Venderova et al.   HUMAN MOLECULAR GENETICS

Dependence of Leucine-rich Repeat Kinase 2 (LRRK2) Kinase Activity on Dimerization

(2009) Saurabh Sen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unexpected Lack of Hypersensitivity in LRRK2 Knock-Out Mice to MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine)

(2009) E. Andres-Mateos et al.   JOURNAL OF NEUROSCIENCE

Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi

(2009) Jennifer L. Mummery-Widmer et al.   NATURE

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

(2009) Wataru Satake et al.   NATURE GENETICS

Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein

(2009) Xian Lin et al.   NEURON

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila HOPS and AP-3 Complex Genes Are Required for a Deltex-Regulated Activation of Notch in the Endosomal Trafficking Pathway

(2008) Marian Wilkin et al.   DEVELOPMENTAL CELL

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

(2008) Yuzuru Imai et al.   EMBO JOURNAL

The Roco protein family: a functional perspective

(2008) Ignacio Marín et al.   FASEB JOURNAL

The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation

(2008) Elisa Greggio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Synuclein Alters Notch-1 Expression and Neurogenesis in Mouse Embryonic Stem Cells and in the Hippocampus of Transgenic Mice

(2008) L. Crews et al.   JOURNAL OF NEUROSCIENCE