Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling

A Broadly Conserved G-Protein-Coupled Receptor Kinase Phosphorylation Mechanism Controls Drosophila Smoothened Activity

(2014) Dominic Maier et al.   PLoS Genetics

Functionally biased signalling properties of 7TM receptors - opportunities for drug development for the ghrelin receptor

(2013) B Sivertsen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Functional selectivity of GPCR signaling in animals

(2013) Lei Zhou et al.   CURRENT OPINION IN CELL BIOLOGY

Hedgehog Pathway Modulation by Multiple Lipid Binding Sites on the Smoothened Effector of Signal Response

(2013) Benjamin R. Myers et al.   DEVELOPMENTAL CELL

Smoothened Oligomerization/Higher Order Clustering in Lipid Rafts Is Essential for High Hedgehog Activity Transduction

(2013) Dawei Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biased Agonism as a Mechanism for Differential Signaling by Chemokine Receptors

(2013) Sudarshan Rajagopal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Unfolded Protein Response Selectively Targets Active Smoothened Mutants

(2013) S. Marada et al.   MOLECULAR AND CELLULAR BIOLOGY

Biased signalling in follicle stimulating hormone action

(2013) Flavie Landomiel et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Structure of the human smoothened receptor bound to an antitumour agent

(2013) Chong Wang et al.   NATURE

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling

(2013) Daniel Nedelcu et al.   Nature Chemical Biology

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cocaine Inhibits Dopamine D2 Receptor Signaling via Sigma-1-D2 Receptor Heteromers

(2013) Gemma Navarro et al.   PLoS One

Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling

(2013) Rajashree Rana et al.   Nature Communications

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

(2013) Sigrid Nachtergaele et al.   eLife

The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation

(2012) C. E. Carroll et al.   DEVELOPMENT

Oxysterols are allosteric activators of the oncoprotein Smoothened

(2012) Sigrid Nachtergaele et al.   Nature Chemical Biology

The Hedgehog Signal Transduction Network

(2012) D. J. Robbins et al.   Science Signaling

USP8 Promotes Smoothened Signaling by Preventing Its Ubiquitination and Changing Its Subcellular Localization

(2012) Ruohan Xia et al.   PLOS BIOLOGY

Hedgehog-Regulated Ubiquitination Controls Smoothened Trafficking and Cell Surface Expression in Drosophila

(2012) Shuang Li et al.   PLOS BIOLOGY

Heterotrimeric GiProteins Link Hedgehog Signaling to Activation of Rho Small GTPases to Promote Fibroblast Migration

(2011) Ariel H. Polizio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Applying label-free dynamic mass redistribution technology to frame signaling of G protein–coupled receptors noninvasively in living cells

(2011) Ralf Schröder et al.   Nature Protocols

Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord

(2011) Y. H. Belgacem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Are circulating gonadotropin isoforms naturally occurring biased agonists? Basic and therapeutic implications

(2011) Brian J. Arey et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Sonic Hedgehog Activates the GTPases Rac1 and RhoA in a Gli-Independent Manner Through Coupling of Smoothened to Gi Proteins

(2011) A. H. Polizio et al.   Science Signaling

Deconvolution of complex G protein–coupled receptor signaling in live cells using dynamic mass redistribution measurements

(2010) Ralf Schröder et al.   NATURE BIOTECHNOLOGY

Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer

(2010) Monique T. Barakat et al.   TRENDS IN MOLECULAR MEDICINE

Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process

(2009) R. Rohatgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G protein Gαi functions immediately downstream of Smoothened in Hedgehog signalling

(2008) Stacey K. Ogden et al.   NATURE

 -Arrestin-Mediated Localization of Smoothened to the Primary Cilium

(2008) J. J. Kovacs et al.   SCIENCE