Role of innate immunity-triggered pathways in the pathogenesis of Sickle Cell Disease: a meta-analysis of gene expression studies

Causes and consequences of coagulation activation in sepsis: an evolutionary medicine perspective

(2015) Maiara Marx Luz Fiusa et al.   BMC Medicine

Excess of heme induces tissue factor-dependent activation of coagulation in mice

(2015) E. M. Sparkenbaugh et al.   HAEMATOLOGICA

Key endothelial cell angiogenic mechanisms are stimulated by the circulating milieu in sickle cell disease and attenuated by hydroxyurea

(2015) F. C. M. Lopes et al.   HAEMATOLOGICA

Pathway and network analysis of cancer genomes

(2015)   NATURE METHODS

Sickle cell disease: renal manifestations and mechanisms

(2015) Karl A. Nath et al.   Nature Reviews Nephrology

The Oxysterol 27-Hydroxycholesterol Increases Oxidative Stress and Regulate Nrf2 Signaling Pathway in Astrocyte Cells

(2015) Wei-Wei Ma et al.   NEUROCHEMICAL RESEARCH

Excess of heme induces tissue factor-dependent activation of coagulation in mice

(2015) E. M. Sparkenbaugh et al.   HAEMATOLOGICA

Key endothelial cell angiogenic mechanisms are stimulated by the circulating milieu in sickle cell disease and attenuated by hydroxyurea

(2015) F. C. M. Lopes et al.   HAEMATOLOGICA

Comparative proteomic analysis of hypertrophic chondrocytes in osteoarthritis

(2015) Konstantinos C Tsolis et al.   Clinical Proteomics

Erythroid DAMPs drive inflammation in SCD

(2014) M. T. Gladwin et al.   BLOOD

Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Kruppel-like factor

(2014) X. Wang et al.   BLOOD

Anti-CD44 Antibody Treatment Lowers Hyperglycemia and Improves Insulin Resistance, Adipose Inflammation, and Hepatic Steatosis in Diet-Induced Obese Mice

(2014) Keiichi Kodama et al.   DIABETES

The genetic basis of pulmonary arterial hypertension

(2014) Lijiang Ma et al.   HUMAN GENETICS

Rap1 Activation Is Required for Fc  Receptor-Dependent Phagocytosis

(2014) J. Chung et al.   JOURNAL OF IMMUNOLOGY

LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures

(2014) Qiaonan Duan et al.   NUCLEIC ACIDS RESEARCH

Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes

(2014) A. R. Majithia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shared signatures between rheumatoid arthritis, systemic lupus erythematosus and Sjögren’s syndrome uncovered through gene expression meta-analysis

(2014) Daniel Toro-Domínguez et al.   ARTHRITIS RESEARCH & THERAPY

Genomic architecture of sickle cell disease in West African children

(2014) Jacklyn Quinlan et al.   Frontiers in Genetics

Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies

(2013) D. Manwani et al.   BLOOD

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

Interplay between coagulation and vascular inflammation in sickle cell disease

(2013) Erica Sparkenbaugh et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hemostatic abnormalities in sickle cell disease

(2013) Ming Y. Lim et al.   CURRENT OPINION IN HEMATOLOGY

The role of high-throughput technologies in clinical cancer genomics

(2013) Saad F Idris et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Nucleosomes and neutrophil activation in sickle cell disease painful crisis

(2013) M. Schimmel et al.   HAEMATOLOGICA

The monocytic population in chronic lymphocytic leukemia shows altered composition and deregulation of genes involved in phagocytosis and inflammation

(2013) R. Maffei et al.   HAEMATOLOGICA

ISG12 is a critical modulator of innate immune responses in murine models of sepsis

(2013) P. Uhrin et al.   IMMUNOBIOLOGY

Extracellular hemin crisis triggers acute chest syndrome in sickle mice

(2013) Samit Ghosh et al.   JOURNAL OF CLINICAL INVESTIGATION

INMEX—a web-based tool for integrative meta-analysis of expression data

(2013) Jianguo Xia et al.   NUCLEIC ACIDS RESEARCH

Global Burden of Sickle Cell Anaemia in Children under Five, 2010–2050: Modelling Based on Demographics, Excess Mortality, and Interventions

(2013) Frédéric B. Piel et al.   PLOS MEDICINE

The Interferon Stimulated Gene 12 Inactivates Vasculoprotective Functions of NR4A Nuclear Receptors

(2012) Nikolina Papac-Milicevic et al.   CIRCULATION RESEARCH

Metabolic Adaptation to a Disruption in Oxygen Supply during Myocardial Ischemia and Reperfusion Is Underpinned by Temporal and Quantitative Changes in the Cardiac Proteome

(2012) Xin Li et al.   JOURNAL OF PROTEOME RESEARCH

Hydroxyurea is associated with reductions in hypercoagulability markers in sickle cell anemia

(2012) M. P. COLELLA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Gene data to hit milestone

(2012) Monya Baker   NATURE

Reuse of public genome-wide gene expression data

(2012) Johan Rung et al.   NATURE REVIEWS GENETICS

Comprehensive literature review and statistical considerations for microarray meta-analysis

(2012) George C. Tseng et al.   NUCLEIC ACIDS RESEARCH

Erythroid-Specific Transcriptional Changes in PBMCs from Pulmonary Hypertension Patients

(2012) Chris Cheadle et al.   PLoS One

Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes

(2012) K. Kodama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression2Kinases: mRNA profiling linked to multiple upstream regulatory layers

(2011) Edward Y. Chen et al.   BIOINFORMATICS

Global Gene Expression Profiling of Endothelium Exposed to Heme Reveals an Organ-Specific Induction of Cytoprotective Enzymes in Sickle Cell Disease

(2011) Samit Ghosh et al.   PLoS One

High levels of placenta growth factor in sickle cell disease promote pulmonary hypertension

(2010) N. Sundaram et al.   BLOOD

The Role of the Transcription Factor CREB in Immune Function

(2010) A. Y. Wen et al.   JOURNAL OF IMMUNOLOGY

Sickle-cell disease

(2010) David C Rees et al.   LANCET

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

(2010)   NATURE BIOTECHNOLOGY

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

Pleiotropic effects of intravascular haemolysis on vascular homeostasis

(2009) Gregory J. Kato et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hemoglobin disorders and endothelial cell interactions

(2009) Nicola Conran et al.   CLINICAL BIOCHEMISTRY

Newer Aspects of the Pathophysiology of Sickle Cell Disease Vaso-Occlusion

(2009) Nicola Conran et al.   HEMOGLOBIN

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

(2009) Nicole Soranzo et al.   NATURE GENETICS

Characterization of Whole Blood Gene Expression Profiles as a Sequel to Globin mRNA Reduction in Patients with Sickle Cell Disease

(2009) Nalini Raghavachari et al.   PLoS One

DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses

(2009) S. Vasseur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease

(2008) A. E. Ashley-Koch et al.   BLOOD

A logic-based diagram of signalling pathways central to macrophage activation

(2008) Sobia Raza et al.   BMC Systems Biology

Reproducible and reliable microarray results through quality control: good laboratory proficiency and appropriate data analysis practices are essential

(2008) Leming Shi et al.   CURRENT OPINION IN BIOTECHNOLOGY

Altered levels of cytokines and inflammatory mediators in plasma and leukocytes of sickle cell anemia patients and effects of hydroxyurea therapy

(2008) C. Lanaro et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Key Issues in Conducting a Meta-Analysis of Gene Expression Microarray Datasets

(2008) Adaikalavan Ramasamy et al.   PLOS MEDICINE