Interplay between coagulation and vascular inflammation in sickle cell disease

A potent oral P-selectin blocking agent improves microcirculatory blood flow and a marker of endothelial cell injury in patients with sickle cell disease

(2012) Abdullah Kutlar et al.   AMERICAN JOURNAL OF HEMATOLOGY

P-selectin glycoprotein ligand-1 inhibition blocks increased leukocyte-endothelial interactions associated with sickle cell disease in mice

(2012) W. Luo et al.   BLOOD

Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease

(2012) P. Chantrathammachart et al.   BLOOD

Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation

(2012) R. Darbousset et al.   BLOOD

Elevated plasma levels and platelet-associated expression of the pro-thrombotic and pro-inflammatory protein, TNFSF14 (LIGHT), in sickle cell disease

(2012) Vanessa T. Garrido et al.   BRITISH JOURNAL OF HAEMATOLOGY

New insights into the mechanisms of venous thrombosis

(2012) Nigel Mackman   JOURNAL OF CLINICAL INVESTIGATION

Platelet- and erythrocyte-derived microparticles trigger thrombin generation via factor XIIa

(2012) P. E. J. VAN DER MEIJDEN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Pulmonary embolism in sickle cell disease: a case-control study

(2012) E. M. NOVELLI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Hydroxyurea is associated with reductions in hypercoagulability markers in sickle cell anemia

(2012) M. P. COLELLA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Association of Coagulation Activation with Clinical Complications in Sickle Cell Disease

(2012) Kenneth I. Ataga et al.   PLoS One

The acceleration of the propagation phase of thrombin generation in patients with steady-state sickle cell disease is associated with circulating erythrocyte-derived microparticles

(2012) Patrick Van Dreden et al.   THROMBOSIS AND HAEMOSTASIS

Thrombin generation reveals high procoagulant potential in the plasma of sickle cell disease children

(2011) Denis F. Noubouossie et al.   AMERICAN JOURNAL OF HEMATOLOGY

Pulmonary Artery Thrombosis during Acute Chest Syndrome in Sickle Cell Disease

(2011) Armand Mekontso Dessap et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S

(2011) F. N. E. Gavins et al.   BLOOD

The rate of hemolysis in sickle cell disease correlates with the quantity of active von Willebrand factor in the plasma

(2011) J. Chen et al.   BLOOD

A pilot study of the short-term use of simvastatin in sickle cell disease: effects on markers of vascular dysfunction

(2011) Carolyn Hoppe et al.   BRITISH JOURNAL OF HAEMATOLOGY

Microparticles in Hemostasis and Thrombosis

(2011) A. Phillip Owens et al.   CIRCULATION RESEARCH

Biomarkers of Inflammation, Growth Factor, and Coagulation Activation in Patients With Sickle Cell Disease

(2011) M. H. Qari et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Differential contributions of monocyte- and platelet-derived microparticles towards thrombin generation and fibrin formation and stability

(2011) M. M. ALEMAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Tissue factor–protease-activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation

(2011) Leylla Badeanlou et al.   NATURE MEDICINE

Thrombosis and Sickle Cell Disease

(2011) Lucia Franceschi et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

P-Selectin–Mediated Platelet-Neutrophil Aggregate Formation Activates Neutrophils in Mouse and Human Sickle Cell Disease

(2010) Renata Polanowska-Grabowska et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of cell adhesion by anti-P-selectin aptamer: a new potential therapeutic agent for sickle cell disease

(2010) D. R. Gutsaeva et al.   BLOOD

Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice

(2010) R. Pawlinski et al.   BLOOD

The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice

(2010) R. P. Hebbel et al.   BLOOD

Increased adhesive properties of platelets in sickle cell disease: roles for αIIbβ3-mediated ligand binding, diminished cAMP signalling and increased phosphodiesterase 3A activity

(2010) Renata Proença-Ferreira et al.   BRITISH JOURNAL OF HAEMATOLOGY

Live/Real Time Three-Dimensional Transthoracic Echocardiographic Assessment of Inferior Vena Cava and Hepatic Vein Thrombosis in Sickle Cell Disease

(2010) Balwinder Singh et al.   ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES

Sickle-cell disease

(2010) David C Rees et al.   LANCET

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

(2010) James E. Bradner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-  and CXCR3 chemokines

(2009) K. L. Wallace et al.   BLOOD

Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13

(2009) J. Chen et al.   BLOOD

Circulating erythrocyte-derived microparticles are associated with coagulation activation in sickle cell disease

(2009) E. J. van Beers et al.   HAEMATOLOGICA

Hypercoagulability and thrombotic complications in hemolytic anemias

(2009) K. I. Ataga   HAEMATOLOGICA

Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury

(2009) Andrés Hidalgo et al.   NATURE MEDICINE

Nuclear factor-kappa B (NFκB) component p50 in blood mononuclear cells regulates endothelial tissue factor expression in sickle transgenic mice: implications for the coagulopathy of sickle cell disease

(2009) Rahn Kollander et al.   Translational Research

D-dimer antigen: current concepts and future prospects

(2008) S. S. Adam et al.   BLOOD

Hypercoagulability in Sickle Cell Disease and Beta-Thalassemia

(2008) Sylvia Singer et al.   CURRENT MOLECULAR MEDICINE

No association of the hypercoagulable state with sickle cell disease related pulmonary hypertension

(2008) E.J. van Beers et al.   HAEMATOLOGICA

Coagulation activation and inflammation in sickle cell disease-associated pulmonary hypertension

(2008) K. I. Ataga et al.   HAEMATOLOGICA

Heme induces endothelial tissue factor expression: potential role in hemostatic activation in patients with hemolytic anemia

(2008) B. N. Y. SETTY et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Increased von Willebrand factor antigen and high molecular weight multimers in sickle cell disease associated with nocturnal hypoxemia

(2008) Suba Krishnan et al.   THROMBOSIS RESEARCH

Mouse models of sickle cell disease

(2008) Y. Beuzard   TRANSFUSION CLINIQUE ET BIOLOGIQUE