Multiplex Imaging and Cellular Target Identification of Kinase Inhibitors via an Affinity-Based Proteome Profiling Approach

Bioorthogonal Reactions for Labeling Proteins

(2014) Kathrin Lang et al.   ACS Chemical Biology

Aurora kinase inhibitor patents and agents in clinical testing: an update (2011 – 2013)

(2014) Chun Hei Antonio Cheung et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

“Minimalist” Cyclopropene-Containing Photo-Cross-Linkers Suitable for Live-Cell Imaging and Affinity-Based Protein Labeling

(2014) Zhengqiu Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

(2014) Bryan R Lanning et al.   Nature Chemical Biology

Design and Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Photo-Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling

(2013) Zhengqiu Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack

(2013) Slava Ziegler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Label Transfer Reagents to Probe p38 MAPK Binding Partners

(2013) Simeon S. Andrews et al.   CHEMBIOCHEM

Modulation of Fatty Acid Synthase Enzyme Activity and Expression during Hepatitis C Virus Replication

(2013) Neda Nasheri et al.   CHEMISTRY & BIOLOGY

Target identification of biologically active small molecules via in situ methods

(2013) Ying Su et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

(2013) Dattatreya Mellacheruvu et al.   NATURE METHODS

Bioorthogonal labelling of biomolecules: new functional handles and ligation methods

(2013) Marjoke F. Debets et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

NudC Deacetylation Regulates Mitotic Progression

(2013) Carol Chuang et al.   PLoS One

Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling

(2012) Chayasith Uttamapinant et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Imaging of Aurora Kinase A in Live Cells

(2012) Katherine S. Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Affinity-Based Probes Based on Type II Kinase Inhibitors

(2012) Pratistha Ranjitkar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell-Based Proteome Profiling of Potential Dasatinib Targets by Use of Affinity-Based Probes

(2012) Haibin Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fully Functionalized Small-Molecule Probes for Integrated Phenotypic Screening and Target Identification

(2012) Justin S. Cisar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Active site profiling reveals coupling between domains in SRC-family kinases

(2012) Ratika Krishnamurty et al.   Nature Chemical Biology

Antibiotic activity and target discovery of three-membered natural product-derived heterocycles in pathogenic bacteria

(2012) Maximilian Pitscheider et al.   Chemical Science

Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M

(2011) Marion Rusch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Increasing the Efficacy of Bioorthogonal Click Reactions for Bioconjugation: A Comparative Study

(2011) Christen Besanceney-Webler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe

(2011) Haibin Shi et al.   CHEMICAL COMMUNICATIONS

Aliphatic Diazirines as Photoaffinity Probes for Proteins: Recent Developments

(2011) Joydip Das   CHEMICAL REVIEWS

Chemical Modification and Organelle-Specific Localization of Orlistat-Like Natural-Product-Based Probes

(2011) Peng-Yu Yang et al.   Chemistry-An Asian Journal

Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel In Vivo Pharmacodynamic Assays

(2011) M. G. Manfredi et al.   CLINICAL CANCER RESEARCH

Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes

(2011) Laura E Edgington et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

(2011) Theonie Anastassiadis et al.   NATURE BIOTECHNOLOGY

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

Drug-Resistant Aurora A Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors MLN8054 and MLN8237

(2010) Dominic A. Sloane et al.   ACS Chemical Biology

Cdk1 Activity Is Required for Mitotic Activation of Aurora A during G2/M Transition of Human Cells

(2010) Robert D. Van Horn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Pyrrole−Indoline-2-ones as Aurora Kinase Inhibitors with a Different Inhibition Profile

(2010) Chao-Cheng Chiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The use of click chemistry in the emerging field of catalomics

(2010) Karunakaran A. Kalesh et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Analysis and Optimization of Copper-Catalyzed Azide–Alkyne Cycloaddition for Bioconjugation

(2009) Vu Hong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Super-Resolution Fluorescence Microscopy

(2009) Bo Huang et al.   Annual Review of Biochemistry

Aurora kinase inhibitors: a new class of drugs targeting the regulatory mitotic system

(2009) José Alejandro Pérez Fidalgo et al.   Clinical & Translational Oncology

Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins

(2009) Mar Carmena et al.   CURRENT OPINION IN CELL BIOLOGY

Activity-Based Proteome Profiling of Potential Cellular Targets of Orlistat − An FDA-Approved Drug with Anti-Tumor Activities

(2009) Peng-Yu Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Target profiling of small molecules by chemical proteomics

(2009) Uwe Rix et al.   Nature Chemical Biology

Identification of the cellular targets of bioactive small organic molecules using affinity reagents

(2008) Benjamin J. Leslie et al.   CHEMICAL SOCIETY REVIEWS

Fluorescent probes for super-resolution imaging in living cells

(2008) Marta Fernández-Suárez et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY