Contact inhibitory Eph signaling suppresses EGF-promoted cell migration by decoupling EGFR activity from vesicular recycling

Reciprocal regulation of signaling and endocytosis: Implications for the evolving cancer cell

(2017) Sandra L. Schmid   JOURNAL OF CELL BIOLOGY

PI(3,4,5)P 3 Engagement Restricts Akt Activity to Cellular Membranes

(2017) Michael Ebner et al.   MOLECULAR CELL

Signal processing by the endosomal system

(2016) Roberto Villaseñor et al.   CURRENT OPINION IN CELL BIOLOGY

EGF-stimulated AKT activation is mediated by EGFR recycling via an early endocytic pathway in a gefitinib-resistant human lung cancer cell line

(2015) YUKIO NISHIMURA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Endomembrane PtdIns(3,4,5)P3 activates the PI3K-Akt pathway

(2015) N. Jethwa et al.   JOURNAL OF CELL SCIENCE

Ubiquitination switches EphA2 vesicular traffic from a continuous safeguard to a finite signalling mode

(2015) Ola Sabet et al.   Nature Communications

PYK2 sustains endosomal-derived receptor signalling and enhances epithelial-to-mesenchymal transition

(2015) Nandini Verma et al.   Nature Communications

Interplay between chemotaxis and contact inhibition of locomotion determines exploratory cell migration

(2015) Benjamin Lin et al.   Nature Communications

EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling

(2015) Martin Baumdick et al.   eLife

Regulation of EGFR signal transduction by analogue-to-digital conversion in endosomes

(2015) Roberto Villaseñor et al.   eLife

The Ephrin-A5/EphA4 Interaction Modulates Neurogenesis and Angiogenesis by the p-Akt and p-ERK Pathways in a Mouse Model of TLE

(2014) Yi Shu et al.   MOLECULAR NEUROBIOLOGY

Activation of Rab8 guanine nucleotide exchange factor Rabin8 by ERK1/2 in response to EGF signaling

(2014) Juanfei Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PIP3 Induces the Recycling of Receptor Tyrosine Kinases

(2014) V. Laketa et al.   Science Signaling

Ultrasensitivity part II: multisite phosphorylation, stoichiometric inhibitors, and positive feedback

(2014) James E. Ferrell et al.   TRENDS IN BIOCHEMICAL SCIENCES

Threshold-controlled ubiquitination of the EGFR directs receptor fate

(2013) Sara Sigismund et al.   EMBO JOURNAL

Live-cell fluorescence imaging reveals high stoichiometry of Grb2 binding to the EGF receptor sustained during endocytosis

(2013) A. Fortian et al.   JOURNAL OF CELL SCIENCE

Therapeutic targeting of EPH receptors and their ligands

(2013) Andrew W. Boyd et al.   NATURE REVIEWS DRUG DISCOVERY

AKT Facilitates EGFR Trafficking and Degradation by Phosphorylating and Activating PIKfyve

(2013) E. E. Er et al.   Science Signaling

Regulation of Signaling at Regions of Cell-Cell Contact by Endoplasmic Reticulum-Bound Protein-Tyrosine Phosphatase 1B

(2012) Fawaz G. Haj et al.   PLoS One

EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex

(2012) Guo Li et al.   Nature Communications

Cell-to-Cell Variability in PI3K Protein Level Regulates PI3K-AKT Pathway Activity in Cell Populations

(2011) Tina L. Yuan et al.   CURRENT BIOLOGY

Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor

(2011) Hiroshi Hanafusa et al.   Nature Communications

Identification of the Switch in Early-to-Late Endosome Transition

(2010) Dmitry Poteryaev et al.   CELL

Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cells

(2010) Nai-Ying Yang et al.   CELLULAR SIGNALLING

Competition amongst Eph receptors regulates contact inhibition of locomotion and invasiveness in prostate cancer cells

(2010) Jonathan W. Astin et al.   NATURE CELL BIOLOGY

EphA2 Mediates Ligand-Dependent Inhibition and Ligand-Independent Promotion of Cell Migration and Invasion via a Reciprocal Regulatory Loop with Akt

(2009) Hui Miao et al.   CANCER CELL

The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK–ERK pathway to late endosomes

(2009) Shigeyki Nada et al.   EMBO JOURNAL

KiSS1 Metastasis Suppressor Gene Product Induces Suppression of Tyrosine Kinase Receptor Signaling to Akt, Tumor Necrosis Factor Family Ligand Expression, and Apoptosis

(2009) J.-M. Navenot et al.   MOLECULAR PHARMACOLOGY

Activation of Rho and Rho-Associated Kinase by GPR54 and KiSS1 Metastasis Suppressor Gene Product Induces Changes of Cell Morphology and Contributes to Apoptosis

(2009) J.-M. Navenot et al.   MOLECULAR PHARMACOLOGY

Population context determines cell-to-cell variability in endocytosis and virus infection

(2009) Berend Snijder et al.   NATURE

Endocytosis and signalling: intertwining molecular networks

(2009) Alexander Sorkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

EphrinA5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor

(2009) J-J Li et al.   ONCOGENE

Global analysis of time correlated single photon counting FRET-FLIM data

(2009) Hernan E. Grecco et al.   OPTICS EXPRESS

The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development

(2008) Annette Schenck et al.   CELL

Eph–ephrin signalling in adult tissues and cancer

(2008) Anna Merlos-Suárez et al.   CURRENT OPINION IN CELL BIOLOGY

Clathrin-Mediated Internalization Is Essential for Sustained EGFR Signaling but Dispensable for Degradation

(2008) Sara Sigismund et al.   DEVELOPMENTAL CELL

Ripples from neighbouring transcription

(2008) Miki Ebisuya et al.   NATURE CELL BIOLOGY

Reproducible, Ultra High-Throughput Formation of Multicellular Organization from Single Cell Suspension-Derived Human Embryonic Stem Cell Aggregates

(2008) Mark D. Ungrin et al.   PLoS One