Mechanisms of initiation and progression of intestinal fibrosis in IBD

Modulation of Liver Fibrosis by Adipokines

(2017) Fabio Marra et al.   DIGESTIVE DISEASES

Localization of ανβ6 integrin-TGF-β1/Smad3, mTOR and PPARγ in experimental colorectal fibrosis

(2014) G. Latella et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

The ratio of transforming growth factor-β1/bone morphogenetic protein-7 in the progression of the epithelial-mesenchymal transition contributes to rat liver fibrosis

(2014) W.R. Bi et al.   GENETICS AND MOLECULAR RESEARCH

Results of the 4th Scientific Workshop of the ECCO (Group II): Markers of intestinal fibrosis in inflammatory bowel disease

(2014) Florian Rieder et al.   Journal of Crohns & Colitis

Results of the 4th scientific workshop of the ECCO (I): Pathophysiology of intestinal fibrosis in IBD

(2014) Giovanni Latella et al.   Journal of Crohns & Colitis

Adiponectin receptors: A review of their structure, function and how they work

(2013) Toshimasa Yamauchi et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Mechanisms of Tissue Remodeling in Inflammatory Bowel Disease

(2013) Florian Rieder et al.   DIGESTIVE DISEASES

Hepatocyte growth factor is an attractive target for the treatment of pulmonary fibrosis

(2013) Sushmita Chakraborty et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

BMP-7 counteracting TGF-beta1 activities in organ fibrosis

(2013) Ralf Weiskirchen   Frontiers in Bioscience-Landmark

Crohn's disease complicated by strictures: a systematic review

(2013) Florian Rieder et al.   GUT

P056 GED-0507–34 Levo, a novel modulator of PPARgamma as new therapeutic strategy in the treatment of intestinal fibrosis

(2013) S. Speca et al.   Journal of Crohns & Colitis

Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/ -Catenin Signaling

(2013) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis

(2013) Petra Simic et al.   Cell Reports

Hedgehog-Gli Pathway Activation during Kidney Fibrosis

(2012) Steven L. Fabian et al.   AMERICAN JOURNAL OF PATHOLOGY

Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease

(2012) Florian Rieder et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis

(2012) Angelika Horn et al.   ANNALS OF THE RHEUMATIC DISEASES

Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis

(2012) Angelika Horn et al.   ARTHRITIS AND RHEUMATISM

Serotonin paracrine signaling in tissue fibrosis

(2012) Derek A. Mann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Klotho in health and disease

(2012) Makoto Kuro-o   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

The Impact of Matrix Metalloproteinases and Their Tissue Inhibitors in Inflammatory Bowel Diseases

(2012) Gábor Lakatos et al.   DIGESTIVE DISEASES

A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling

(2012) Masamichi Imajo et al.   EMBO JOURNAL

YAP regulates neuronal differentiation through Sonic hedgehog signaling pathway

(2012) Yi-Ting Lin et al.   EXPERIMENTAL CELL RESEARCH

Adipose Tissue and Inflammatory Bowel Disease Pathogenesis

(2012) Christopher Fink et al.   INFLAMMATORY BOWEL DISEASES

Treatment of inflammatory bowel diseases: To heal the wound or to heal the sick?

(2012) Renzo Caprilli et al.   Journal of Crohns & Colitis

Decorin–TGFβ Axis in Hepatic Fibrosis and Cirrhosis

(2012) Kornélia Baghy et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Targeting Peroxisome Proliferator-Activated Receptors (PPARs): Development of Modulators

(2012) Céline Pirat et al.   JOURNAL OF MEDICINAL CHEMISTRY

Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis

(2012) Hikaru Sugimoto et al.   NATURE MEDICINE

A systems approach identifies HIPK2 as a key regulator of kidney fibrosis

(2012) Yuanmeng Jin et al.   NATURE MEDICINE

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Significance of the Balance between Regulatory T (Treg) and T Helper 17 (Th17) Cells during Hepatitis B Virus Related Liver Fibrosis

(2012) Jing Li et al.   PLoS One

Inhibition of Notch Signaling by a γ-Secretase Inhibitor Attenuates Hepatic Fibrosis in Rats

(2012) Yixiong Chen et al.   PLoS One

Crucial steps in the natural history of inflammatory bowel disease

(2012) Giovanni Latella   WORLD JOURNAL OF GASTROENTEROLOGY

Cellular and molecular mechanisms of intestinal fibrosis

(2012) Silvia Speca   WORLD JOURNAL OF GASTROENTEROLOGY

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

(2012) Alfiya Akhmetshina et al.   Nature Communications

Mesenchymal cell proliferation and programmed cell death: key players in fibrogenesis and new targets for therapeutic intervention

(2011) Jeroni Luna et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Themes in fibrosis and gastrointestinal inflammation

(2011) Claudio Fiocchi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

SIRT1 inhibits the mouse intestinal motility and epithelial proliferation

(2011) Yi Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Peroxisome proliferator-activated receptor-γ cross-regulation of signaling events implicated in liver fibrogenesis

(2011) Feng Zhang et al.   CELLULAR SIGNALLING

Epidemiology and Natural History of Inflammatory Bowel Diseases

(2011) Jacques Cosnes et al.   GASTROENTEROLOGY

Surgery for adult Crohn's disease: what is the actual risk?

(2011) G. Bouguen et al.   GUT

Pharmacological intervention studies using mouse models of the inflammatory bowel diseases

(2011) Iurii Koboziev et al.   INFLAMMATORY BOWEL DISEASES

Predictors of fibrostenotic Crohnʼs disease

(2011) Florian Rieder et al.   INFLAMMATORY BOWEL DISEASES

MicroRNAs in inflammatory bowel disease

(2011) Joel R. Pekow et al.   INFLAMMATORY BOWEL DISEASES

Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice

(2011) Shigehiro Doi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Results of the 2nd Scientific Workshop of the ECCO (III): Basic mechanisms of intestinal healing

(2011) Florian Rieder et al.   Journal of Crohns & Colitis

Hepatocyte growth factor in lung repair and pulmonary fibrosis

(2010) Ronald Allan M Panganiban et al.   ACTA PHARMACOLOGICA SINICA

Intestinal Fibrosis in Crohns Disease: Medical Treatment or Surgery?

(2010) Antonino Spinelli et al.   CURRENT DRUG TARGETS

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

MicroRNAs and the regulation of fibrosis

(2010) Xiaoying Jiang et al.   FEBS Journal

BMP-7 as antagonist of organ fibrosis

(2010) Ralf Weiskirchen   Frontiers in Bioscience-Landmark

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

(2010) Bernhard Bielesz et al.   JOURNAL OF CLINICAL INVESTIGATION

The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management

(2010) A. Dignass et al.   Journal of Crohns & Colitis

In favour of early surgery in Crohn's disease: A hypothesis to be tested

(2010) Giovanni Latella et al.   Journal of Crohns & Colitis

Inhibition of Wnt/ -catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis

(2010) W. R. Henderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOD2/CARD15,ATG16L1andIL23Rgene polymorphisms and childhood-onset of Crohn’s disease

(2010) Maria Gazouli   WORLD JOURNAL OF GASTROENTEROLOGY

Notch1 Signaling in FIZZ1 Induction of Myofibroblast Differentiation

(2009) Tianju Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Activation of peroxisome proliferator-activated receptor-γ inhibits transforming growth factor-β1 induction of connective tissue growth factor and extracellular matrix in hypertrophic scar fibroblasts in vitro

(2009) Guo-You Zhang et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Loss of peroxisome proliferator-activated receptor γ in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis

(2009) Mohit Kapoor et al.   ARTHRITIS AND RHEUMATISM

Targeting Matrix Metalloproteinases in Inflammatory Conditions

(2009) A. Clutterbuck et al.   CURRENT DRUG TARGETS

Smad3 loss confers resistance to the development of trinitrobenzene sulfonic acid-inducedcolorectal fibrosis

(2009) G. Latella et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Serotonin Has a Key Role in Pathogenesis of Experimental Colitis

(2009) Jean–Eric Ghia et al.   GASTROENTEROLOGY

Transforming growth factor   signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures

(2009) A Di Sabatino et al.   GUT

Outcome of medical treatment of stricturing and penetrating Crohnʼs disease

(2009) Roxana Samimi et al.   INFLAMMATORY BOWEL DISEASES

Intestinal fibrosis in IBD—a dynamic, multifactorial process

(2009) Florian Rieder et al.   Nature Reviews Gastroenterology & Hepatology

A Multicenter, Randomized, Double-Blind Trial of EverolimusVersusAzathioprine and Placebo to Maintain Steroid-Induced Remission in Patients With Moderate-to-Severe Active Crohn's Disease

(2008) Walter Reinisch et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Modulation of bleomycin-induced lung fibrosis by serotonin receptor antagonists in mice

(2008) A. Fabre et al.   EUROPEAN RESPIRATORY JOURNAL

HGF as a renotrophic and anti-fibrotic regulator in chronic renal disease

(2008) Shinya Mizuno   Frontiers in Bioscience-Landmark

IL-13 Signaling via IL-13Rα2 Induces Major Downstream Fibrogenic Factors Mediating Fibrosis in Chronic TNBS Colitis

(2008) Stefan Fichtner–Feigl et al.   GASTROENTEROLOGY

Use of sirolimus (rapamycin) to treat refractory Crohn's disease

(2008) D C O Massey et al.   GUT

Long-term outcome of treatment with infliximab in 614 patients with Crohn's disease: results from a single-centre cohort

(2008) F Schnitzler et al.   GUT

Do metalloproteinases contribute to tissue destruction or remodeling in the inflamed gut?

(2008) Sylvia L. F. Pender   INFLAMMATORY BOWEL DISEASES

Everolimus for refractory Crohnʼs disease: A case report

(2008) Jérôme Dumortier et al.   INFLAMMATORY BOWEL DISEASES

Leptin, adiponectin, resistin, and ghrelin - Implications for inflammatory bowel disease

(2008) Konstantinos Karmiris et al.   MOLECULAR NUTRITION & FOOD RESEARCH