New Insights into the Pros and Cons of the Clinical Use of Vitamin K Antagonists (VKAs) Versus Direct Oral Anticoagulants (DOACs)

Antidotes for Novel Oral Anticoagulants

(2015) Mark Crowther et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Overview of the New Oral Anticoagulants: Opportunities and Challenges

(2015) C. H. Yeh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Prevention of vasculopathy by vitamin K supplementation: Can we turn fiction into fact?

(2015) Vincent M. Brandenburg et al.   ATHEROSCLEROSIS

Vascular calcification: from pathophysiology to biomarkers

(2015) Séverine Evrard et al.   CLINICA CHIMICA ACTA

Vascular calcification in chronic kidney disease: an update

(2015) Georg Schlieper et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Targeted Anti-Anticoagulants

(2015) Kenneth A. Bauer   NEW ENGLAND JOURNAL OF MEDICINE

Idarucizumab for Dabigatran Reversal

(2015) Charles V. Pollack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Laboratory Testing in the Era of Direct or Non–Vitamin K Antagonist Oral Anticoagulants: A Practical Guide to Measuring Their Activity and Avoiding Diagnostic Errors

(2015) Giuseppe Lippi et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Experimental research Thrombin inhibition by dabigatran attenuates atherosclerosis in ApoE deficient mice

(2014) Simon Pingel et al.   Archives of Medical Science

Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials

(2014) N. van Es et al.   BLOOD

The potential of target-specific oral anticoagulants for the acute and long-term treatment of venous thromboembolism

(2014) Frank Akwaa et al.   CURRENT MEDICAL RESEARCH AND OPINION

RANKL–OPG and RAGE modulation in vascular calcification and diabetes: novel targets for therapy

(2014) Agbor Ndip et al.   DIABETOLOGIA

Hydroxyapatite and calcified elastin induce osteoblast-like differentiation in rat aortic smooth muscle cells

(2014) Yang Lei et al.   EXPERIMENTAL CELL RESEARCH

Dietary Intake of Vitamin K Is Inversely Associated with Mortality Risk

(2014) Martí Juanola-Falgarona et al.   JOURNAL OF NUTRITION

The realm of vitamin K dependent proteins: Shifting from coagulation toward calcification

(2014) Brecht A. G. Willems et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The impact of warfarin on the rate of progression of aortic stiffness in hemodialysis patients: a longitudinal study

(2014) Fabrice Mac-Way et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Combined Administration of Antibiotics and Direct Oral Anticoagulants: A Renewed Indication for Laboratory Monitoring?

(2014) Emmanuel Favaloro et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Differential cellular effects of old and new oral anticoagulants: consequences to the genesis and progression of atherosclerosis

(2014) Henri Spronk et al.   THROMBOSIS AND HAEMOSTASIS

Functional role of protease activated receptors in vascular biology

(2014) Maria Adele Alberelli et al.   VASCULAR PHARMACOLOGY

Dabigatran, bleeding, and the regulators

(2014) T. J. Moore et al.   BMJ-British Medical Journal

Dabigatran: how the drug company withheld important analyses

(2014) D. Cohen   BMJ-British Medical Journal

Warfarin Induces Cardiovascular Damage in Mice

(2013) Thilo Krüger et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The role of menaquinones (vitamin K2) in human health

(2013) Joline W. J. Beulens et al.   BRITISH JOURNAL OF NUTRITION

Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells

(2013) Andreas Böhm et al.   CARDIOVASCULAR RESEARCH

Structural and functional insights into human vitamin K epoxide reductase and vitamin K epoxide reductase-like1

(2013) Wade D. Van Horn   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Elastin Haploinsufficiency Impedes the Progression of Arterial Calcification in MGP-Deficient Mice

(2013) Zohreh Khavandgar et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Effect of low-dose supplements of menaquinone-7 (vitamin K2) on the stability of oral anticoagulant treatment: dose-response relationship in healthy volunteers

(2013) E. Theuwissen et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Thrombin generation and atherosclerosis

(2013) Jana Kalz et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

A clinical and pharmacologic assessment of once-daily versus twice-daily dosing for rivaroxaban

(2013) Reinhold Kreutz   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Dietary vitamin K and therapeutic warfarin alter the susceptibility to vascular calcification in experimental chronic kidney disease

(2013) Kristin M. McCabe et al.   KIDNEY INTERNATIONAL

18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial

(2013) Nikhil V Joshi et al.   LANCET

Targeting factor Xa and thrombin: impact on coagulation and beyond

(2013) Charles T. Esmon   THROMBOSIS AND HAEMOSTASIS

Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization

(2013) Leon J. Schurgers et al.   TRENDS IN MOLECULAR MEDICINE

Vascular calcification: The price to pay for anticoagulation therapy with vitamin K-antagonists

(2012) Martijn L.L. Chatrou et al.   BLOOD REVIEWS

The Beneficial Effects of a Direct Thrombin Inhibitor, Dabigatran Etexilate, on the Development and Stability of Atherosclerotic Lesions in Apolipoprotein E-deficient Mice

(2012) Nikolaos P. E. Kadoglou et al.   CARDIOVASCULAR DRUGS AND THERAPY

Executive Summary

(2012) Gordon H. Guyatt et al.   CHEST

Oral Direct Factor Xa Inhibitors

(2012) Calvin H. Yeh et al.   CIRCULATION RESEARCH

Physiology, pharmacology, and therapeutic potential of protease-activated receptors in vascular disease

(2012) Hannah Lee et al.   PHARMACOLOGY & THERAPEUTICS

The effects of warfarin and edoxaban, an oral direct factor Xa inhibitor, on gammacarboxylated (Gla-osteocalcin) and undercarboxylated osteocalcin (uc-osteocalcin) in rats

(2012) Yoshiyuki Morishima et al.   THROMBOSIS RESEARCH

Accelerated In Vivo Thrombin Formation Independently Predicts the Presence and Severity of CT Angiographic Coronary Atherosclerosis

(2012) Julian I. Borissoff et al.   JACC-Cardiovascular Imaging

Gla-Rich Protein, a New Player in Tissue Calcification?

(2012) M. Leonor Cancela et al.   Advances in Nutrition

Effect of Vitamin K2 Supplementation on Functional Vitamin K Deficiency in Hemodialysis Patients: A Randomized Trial

(2011) Ralf Westenfeld et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Microcalcifications in Early Intimal Lesions of Atherosclerotic Human Coronary Arteries

(2011) Ruben B. Roijers et al.   AMERICAN JOURNAL OF PATHOLOGY

Osteocalcin

(2011) Alexander N. Kapustin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Ucma is not necessary for normal development of the mouse skeleton

(2011) Nicole Eitzinger et al.   BONE

The Regulation of Valvular and Vascular Sclerosis by Osteogenic Morphogens

(2011) Kristina I. Boström et al.   CIRCULATION RESEARCH

Circulating levels of non-phosphorylated undercarboxylated matrix Gla protein are associated with disease severity in patients with chronic heart failure

(2011) Thor Ueland et al.   CLINICAL SCIENCE

Blood coagulation factor Xa as an emerging drug target

(2011) Keren Borensztajn et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The antioxidant tempol ameliorates arterial medial calcification in uremic rats: Important role of oxidative stress in the pathogenesis of vascular calcification in chronic kidney disease

(2011) Shunsuke Yamada et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Matrix Gla Protein Inhibits Ectopic Calcification by a Direct Interaction with Hydroxyapatite Crystals

(2011) Jason O’Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Circulating Nonphosphorylated Carboxylated Matrix Gla Protein Predicts Survival in ESRD

(2011) G. Schlieper et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Circulating matrix γ-carboxyglutamate protein (MGP) species are refractory to vitamin K treatment in a new case of Keutel syndrome

(2011) E. C. M. CRANENBURG et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Evaluation of Plaque Stability of Advanced Atherosclerotic Lesions in Apo E-Deficient Mice after Treatment with the Oral Factor Xa Inhibitor Rivaroxaban

(2011) Qianxing Zhou et al.   MEDIATORS OF INFLAMMATION

The Hemostatic System as a Modulator of Atherosclerosis

(2011) Julian Ilcheff Borissoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Apixaban versus Warfarin in Patients with Atrial Fibrillation

(2011) Christopher B. Granger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation

(2011) Manesh R. Patel et al.   NEW ENGLAND JOURNAL OF MEDICINE

The roles of thrombin and protease-activated receptors in inflammation

(2011) Liang Ma et al.   Seminars in Immunopathology

Inhibition of Bone Morphogenetic Proteins Protects Against Atherosclerosis and Vascular Calcification

(2010) Yucheng Yao et al.   CIRCULATION RESEARCH

Upregulation of Proteinase-Activated Receptor-2 and Increased Response to Trypsin in Endothelial Cells after Exposure to Oxidative Stress in Rat Aortas

(2010) Murasaki Aman et al.   JOURNAL OF VASCULAR RESEARCH

Undercarboxylated Osteocalcin Is a Biomarker of Carotid Calcification in Patients with Essential Hypertension

(2010) Takafumi Okura et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Oral Rivaroxaban for Symptomatic Venous Thromboembolism

(2010)   NEW ENGLAND JOURNAL OF MEDICINE

Apixaban versus Enoxaparin for Thromboprophylaxis after Hip Replacement

(2010) Michael Rud Lassen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gla-Rich Protein Is a Novel Vitamin K-Dependent Protein Present in Serum That Accumulates at Sites of Pathological Calcifications

(2009) Carla S.B. Viegas et al.   AMERICAN JOURNAL OF PATHOLOGY

Mineralization by Inhibitor Exclusion

(2009) Paul A. Price et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oral rivaroxaban for the prevention of symptomatic venous thromboembolism after elective hip and knee replacement

(2009) B. I. Eriksson et al.   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

Dabigatran versus Warfarin in Patients with Atrial Fibrillation

(2009) Stuart J. Connolly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism

(2009) Sam Schulman et al.   NEW ENGLAND JOURNAL OF MEDICINE

High dietary menaquinone intake is associated with reduced coronary calcification

(2008) Joline W.J. Beulens et al.   ATHEROSCLEROSIS

Influence of microcalcifications on vulnerable plaque mechanics using FSI modeling

(2008) Danny Bluestein et al.   JOURNAL OF BIOMECHANICS

Effect of osteocalcin deficiency on the nanomechanics and chemistry of mouse bones

(2008) N.B. Kavukcuoglu et al.   Journal of the Mechanical Behavior of Biomedical Materials

The Circulating Inactive Form of Matrix Gla Protein (ucMGP) as a Biomarker for Cardiovascular Calcification

(2008) Ellen C.M. Cranenburg et al.   JOURNAL OF VASCULAR RESEARCH

Rivaroxaban versus Enoxaparin for Thromboprophylaxis after Hip Arthroplasty

(2008) Bengt I. Eriksson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacogenetic differences between warfarin, acenocoumarol and phenprocoumon

(2008) Jacobus R. B. J. Brouwers et al.   THROMBOSIS AND HAEMOSTASIS

The direct thrombin inhibitor hirudin

(2008) Theodore Warkentin et al.   THROMBOSIS AND HAEMOSTASIS

Thrombin and protease-activated receptors (PARs) in atherothrombosis

(2008) Lluis Martorell et al.   THROMBOSIS AND HAEMOSTASIS

Metabolism and cell biology of vitamin K

(2008) Paul Newman et al.   THROMBOSIS AND HAEMOSTASIS

Factor Xa: at the crossroads between coagulation and signaling in physiology and disease

(2008) Keren Borensztajn et al.   TRENDS IN MOLECULAR MEDICINE