The roles of thrombin and protease-activated receptors in inflammation

Thrombin Induces Macrophage Migration Inhibitory Factor Release and Upregulation in Urothelium: A Possible Contribution to Bladder Inflammation

(2011) Pedro L. Vera et al.   PLoS One

Proteinase-activated receptors-1 and 2 induce electrogenic Cl− secretion in the mouse cecum by distinct mechanisms

(2010) Osamu Ikehara et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Thrombin promotes proinflammatory phenotype in human vascular smooth muscle cell

(2010) Sung-Woon Chung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Proteinase-activated receptors induce interleukin-8 expression by intestinal epithelial cells through ERK/RSK90 activation and histone acetylation

(2010) Hongying Wang et al.   FASEB JOURNAL

Thrombin-dependent NF-κB Activation and Monocyte/Endothelial Adhesion Are Mediated by the CARMA3·Bcl10·MALT1 Signalosome

(2010) Phillip C. Delekta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficiency of PAR4 Attenuates Cerebral Ischemia/Reperfusion Injury in Mice

(2010) Yingying Mao et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

 -Synuclein Activates Microglia by Inducing the Expressions of Matrix Metalloproteinases and the Subsequent Activation of Protease-Activated Receptor-1

(2010) E.-J. Lee et al.   JOURNAL OF IMMUNOLOGY

Human cytomegalovirus increases HUVEC sensitivity to thrombin and modulates expression of thrombin receptors

(2010) Milan Popović et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Luminal Cathepsin G and Protease-Activated Receptor 4

(2009) Marta Dabek et al.   AMERICAN JOURNAL OF PATHOLOGY

Tissue Factor-Deficiency and Protease Activated Receptor-1-Deficiency Reduce Inflammation Elicited by Diet-Induced Steatohepatitis in Mice

(2009) James P. Luyendyk et al.   AMERICAN JOURNAL OF PATHOLOGY

Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality

(2009) F. Niessen et al.   BLOOD

Thrombin induces the expression of oncostatin M via AP-1 activation in human macrophages: a link between coagulation and inflammation

(2009) S. P. Kastl et al.   BLOOD

Platelet Matrix Metalloprotease-1 Mediates Thrombogenesis by Activating PAR1 at a Cryptic Ligand Site

(2009) Vishal Trivedi et al.   CELL

Proteinase-activated receptor-2 mediated inhibition of TNFα-stimulated JNK activation — A novel paradigm for Gq/11 linked GPCRs

(2009) Kathryn McIntosh et al.   CELLULAR SIGNALLING

Protease-activated receptor 1-dependent neuronal damage involves NMDA receptor function

(2009) Cecily E. Hamill et al.   EXPERIMENTAL NEUROLOGY

Protease-Activated Receptor-1 Down-regulates the Murine Inflammatory and Humoral Response to Helicobacter pylori

(2009) Janet L.K. Wee et al.   GASTROENTEROLOGY

Protease-activated receptor-1 regulates cytokine production and induces the suppressor of cytokine signaling-3 in microglia

(2009) Fabrizi   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Concentration dependent dual effect of thrombin in endothelial cells via Par-1 and Pi3 Kinase

(2009) Jong-Sup Bae et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Complement Protease MASP-1 Activates Human Endothelial Cells: PAR4 Activation Is a Link between Complement and Endothelial Function

(2009) M. Megyeri et al.   JOURNAL OF IMMUNOLOGY

Thrombin increases inflammatory cytokine and angiogenic growth factor secretion in human adipose cells in vitro

(2009) Jennifer L Strande et al.   Journal of Inflammation-London

αA-crystallin and αB-crystallin, newly identified interaction proteins of protease-activated receptor-2, rescue astrocytes from C2-ceramide- and staurosporine-induced cell death

(2009) Rongyu Li et al.   JOURNAL OF NEUROCHEMISTRY

Proteinase-Activated Receptor-4 (PAR4) Activation Leads to Sensitization of Rat Joint Primary Afferents Via a Bradykinin B2 Receptor-Dependent Mechanism

(2009) Fiona A. Russell et al.   JOURNAL OF NEUROPHYSIOLOGY

Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo

(2009) Q M Nhu et al.   Mucosal Immunology

PROTEASE-ACTIVATED RECEPTOR 2 BLOCKING PEPTIDE COUNTERACTS ENDOTOXIN-INDUCED INFLAMMATION AND COAGULATION AND AMELIORATES RENAL FIBRIN DEPOSITION IN A RAT MODEL OF ACUTE RENAL FAILURE

(2009) Subrina Jesmin et al.   SHOCK

Hug Tightly and Say Goodbye: Role of Endothelial ICAM-1 in Leukocyte Transmigration

(2008) Arshad Rahman et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of the coagulation system in allergic inflammation in the upper airways

(2008) Shino Shimizu et al.   CLINICAL IMMUNOLOGY

CUX1 Transcription Factor Is a Downstream Effector of the Proteinase-activated Receptor 2 (PAR2)

(2008) Brian J. Wilson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of Proteinase-activated Receptor 2 and TLR4 Signal Transduction

(2008) Prasad Rallabhandi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1–dependent leukocyte recruitment in vivo

(2008) Daxin Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation

(2008) Frank Niessen et al.   NATURE