Vascular calcification in chronic kidney disease: an update

The vulnerable patient with chronic kidney disease

(2015) Georg Schlieper et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Pro: Cardiovascular calcifications are clinically relevant

(2015) J. Bover et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Con: Vascular calcification is a surrogate marker, but not the cause of ongoing vascular disease, and it is not a treatment target in chronic kidney disease

(2015) C. Zoccali et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Overexpression of C1q/Tumor Necrosis Factor–Related Protein-3 Promotes Phosphate-Induced Vascular Smooth Muscle Cell Calcification Both In Vivo and In Vitro

(2014) Yun Zhou et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Medial vascular calcification revisited: review and perspectives

(2014) P. Lanzer et al.   EUROPEAN HEART JOURNAL

The Effect of Ageing on Vascular Smooth Muscle Cell Behaviour - A Mini-Review

(2014) Bethan Alice Monk et al.   GERONTOLOGY

Effects of phosphorus-restricted diet and phosphate-binding therapy on outcomes in patients with chronic kidney disease

(2014) Domenico Russo et al.   JOURNAL OF NEPHROLOGY

Vascular calcification is dependent on plasma levels of pyrophosphate

(2014) Koba A. Lomashvili et al.   KIDNEY INTERNATIONAL

Vascular calcification in chronic kidney disease: not all arteries are created equal

(2014) Georg Schlieper   KIDNEY INTERNATIONAL

Calcific uraemic arteriolopathy: a rare disease with a potentially high impact on chronic kidney disease–mineral and bone disorder

(2014) Vincent M. Brandenburg et al.   PEDIATRIC NEPHROLOGY

Fetuin-A and Albumin Alter Cytotoxic Effects of Calcium Phosphate Nanoparticles on Human Vascular Smooth Muscle Cells

(2014) Yana Dautova et al.   PLoS One

Vitamin K Antagonists: Beyond Bleeding

(2014) Thilo Krüger et al.   SEMINARS IN DIALYSIS

Role of Extracellular Vesicles in De Novo Mineralization

(2013) Sophie E. P. New et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Prelamin A Accelerates Vascular Calcification Via Activation of the DNA Damage Response and Senescence-Associated Secretory Phenotype in Vascular Smooth Muscle Cells

(2013) Yiwen Liu et al.   CIRCULATION RESEARCH

Vascular remodeling and media calcification increases arterial stiffness in chronic kidney disease

(2013) Alexandra Gauthier-Bastien et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Vascular calcification

(2013) Ziad A. Massy et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Elastin Haploinsufficiency Impedes the Progression of Arterial Calcification in MGP-Deficient Mice

(2013) Zohreh Khavandgar et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Lanthanum Carbonate Delays Progression of Coronary Artery Calcification Compared With Calcium-Based Phosphate Binders in Patients on Hemodialysis

(2013) Takayasu Ohtake et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Fibroblast growth factor 23 is not associated with and does not induce arterial calcification

(2013) Julia J. Scialla et al.   KIDNEY INTERNATIONAL

Phosphate restriction significantly reduces mortality in uremic rats with established vascular calcification

(2013) Jane L. Finch et al.   KIDNEY INTERNATIONAL

Breast arterial calcification in chronic kidney disease: absence of smooth muscle apoptosis and osteogenic transdifferentiation

(2013) W. Charles O'Neill et al.   KIDNEY INTERNATIONAL

Effect of calcium-based versus non-calcium-based phosphate binders on mortality in patients with chronic kidney disease: an updated systematic review and meta-analysis

(2013) Sophie A Jamal et al.   LANCET

Mechanisms of vascular calcification in CKD—evidence for premature ageing?

(2013) Catherine M. Shanahan   Nature Reviews Nephrology

Vitamin K1 to slow vascular calcification in haemodialysis patients (VitaVasK trial): a rationale and study protocol

(2013) T. Krueger et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Cholecalciferol in haemodialysis patients: a randomized, double-blind, proof-of-concept and safety study

(2013) Pierre Delanaye et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Palmitic Acid Induces Osteoblastic Differentiation in Vascular Smooth Muscle Cells through ACSL3 and NF-κB, Novel Targets of Eicosapentaenoic Acid

(2013) Aiko Kageyama et al.   PLoS One

Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization

(2013) Leon J. Schurgers et al.   TRENDS IN MOLECULAR MEDICINE

Inhibition of Bone Morphogenetic Protein Signaling Reduces Vascular Calcification and Atherosclerosis

(2012) Matthias Derwall et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Vascular Klotho Deficiency Potentiates the Development of Human Artery Calcification and Mediates Resistance to Fibroblast Growth Factor 23

(2012) Kenneth Lim et al.   CIRCULATION

Clearance of Fetuin-A–Containing Calciprotein Particles Is Mediated by Scavenger Receptor-A

(2012) Marietta Herrmann et al.   CIRCULATION RESEARCH

Smooth Muscle Cell–Specific Runx2 Deficiency Inhibits Vascular Calcification

(2012) Yong Sun et al.   CIRCULATION RESEARCH

Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification

(2012) Tina Kiffer-Moreira et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Effects of Phosphate Binders in Moderate CKD

(2012) G. A. Block et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mechanistic Insights into Vascular Calcification in CKD

(2012) R. Shroff et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Calcium balance in normal individuals and in patients with chronic kidney disease on low- and high-calcium diets

(2012) David M. Spiegel et al.   KIDNEY INTERNATIONAL

Optimizing the dialysate calcium concentration in bicarbonate haemodialysis

(2012) G. Bosticardo et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The ups and downs of dialysate calcium concentration in haemodialysis patients

(2012) Piergiorgio Messa   NEPHROLOGY DIALYSIS TRANSPLANTATION

Protocol adherence and the progression of cardiovascular calcification in the ADVANCE study

(2012) Pablo A. Ureña-Torres et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Effect of Sevelamer and Calcium-Based Phosphate Binders on Coronary Artery Calcification and Accumulation of Circulating Advanced Glycation End Products in Hemodialysis Patients

(2011) Takatoshi Kakuta et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Effect of Dialysate Calcium Concentrations on Parathyroid Hormone and Calcium Balance During a Single Dialysis Session Using Bicarbonate Hemodialysis: A Crossover Clinical Trial

(2011) Carlo Basile et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Effect of Vitamin K2 Supplementation on Functional Vitamin K Deficiency in Hemodialysis Patients: A Randomized Trial

(2011) Ralf Westenfeld et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Progression of Coronary Artery Calcification and Thoracic Aorta Calcification in Kidney Transplant Recipients

(2011) Céline Maréchal et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Effects of Sodium Thiosulfate on Vascular Calcification in End-Stage Renal Disease: A Pilot Study of Feasibility, Safety and Efficacy

(2011) Santhosh Jay Mathews et al.   AMERICAN JOURNAL OF NEPHROLOGY

Elastin Degradation and Vascular Smooth Muscle Cell Phenotype Change Precede Cell Loss and Arterial Medial Calcification in a Uremic Mouse Model of Chronic Kidney Disease

(2011) Ashwini Pai et al.   AMERICAN JOURNAL OF PATHOLOGY

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

(2011) Bence György et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Regulation of Valvular and Vascular Sclerosis by Osteogenic Morphogens

(2011) Kristina I. Boström et al.   CIRCULATION RESEARCH

Calcium Regulates Key Components of Vascular Smooth Muscle Cell–Derived Matrix Vesicles to Enhance Mineralization

(2011) Alexander N. Kapustin et al.   CIRCULATION RESEARCH

Cinacalcet reduces vascular and soft tissue calcification in secondary hyperparathyroidism (SHPT) in hemodialysis patients

(2011) M.J. Aladrén Regidor   CLINICAL NEPHROLOGY

The KDIGO guideline on dialysate calcium and patient outcomes: need for hard evidence

(2011) Sharon M. Moe et al.   KIDNEY INTERNATIONAL

NT5EMutations and Arterial Calcifications

(2011) Cynthia St. Hilaire et al.   NEW ENGLAND JOURNAL OF MEDICINE

Arterial aging and arterial disease: interplay between central hemodynamics, cardiac work, and organ flow—implications for CKD and cardiovascular disease

(2011) Gerard London et al.   Kidney International Supplements

Effect of Alendronate on Vascular Calcification in CKD Stages 3 and 4: A Pilot Randomized Controlled Trial

(2010) Nigel D. Toussaint et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Prelamin A Acts to Accelerate Smooth Muscle Cell Senescence and Is a Novel Biomarker of Human Vascular Aging

(2010) Cassandra D. Ragnauth et al.   CIRCULATION

Vascular Smooth Muscle Cell Differentiation to an Osteogenic Phenotype Involves TRPM7 Modulation by Magnesium

(2010) Augusto C. Montezano et al.   HYPERTENSION

Oxidized low-density lipoprotein promotes osteoblast differentiation in primary cultures of vascular smooth muscle cells by up-regulatingOsterixexpression in an Msx2-dependent manner

(2010) Jesse Taylor et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Ultrastructural Analysis of Vascular Calcifications in Uremia

(2010) G. Schlieper et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The KDIGO guideline for dialysate calcium will result in an increased incidence of calcium accumulation in hemodialysis patients

(2010) Frank A. Gotch et al.   KIDNEY INTERNATIONAL

Attenuation of aortic calcification with lanthanum carbonate versus calcium-based phosphate binders in haemodialysis: A pilot randomized controlled trial

(2010) NIGEL D TOUSSAINT et al.   NEPHROLOGY

Serum iPTH, calcium and phosphate, and the risk of mortality in a European haemodialysis population

(2010) J. Floege et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The ADVANCE study: a randomized study to evaluate the effects of cinacalcet plus low-dose vitamin D on vascular calcification in patients on hemodialysis

(2010) P. Raggi et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Elastin Degradation Accelerates Phosphate-Induced Mineralization of Vascular Smooth Muscle Cells

(2009) Nozomu Hosaka et al.   CALCIFIED TISSUE INTERNATIONAL

Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease

(2009) Elena Aikawa et al.   CIRCULATION

Smooth Muscle Cells Give Rise to Osteochondrogenic Precursors and Chondrocytes in Calcifying Arteries

(2009) Mei Y. Speer et al.   CIRCULATION RESEARCH

The calcimimetic AMG 641 abrogates parathyroid hyperplasia, bone and vascular calcification abnormalities in uremic rats

(2009) Charles Henley et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Type 3 cystatins; fetuins, kininogen and histidine-rich glycoprotein

(2009) Chunsik Lee   Frontiers in Bioscience-Landmark

Long-term effects of magnesium carbonate on coronary artery calcification and bone mineral density in hemodialysis patients: A pilot study

(2009) David M. SPIEGEL et al.   Hemodialysis International

Pseudoxanthoma Elasticum: Molecular Genetics and Putative Pathomechanisms

(2009) Jouni Uitto et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Fetuin-A Protects against Atherosclerotic Calcification in CKD

(2009) R. Westenfeld et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Chronic Mineral Dysregulation Promotes Vascular Smooth Muscle Cell Adaptation and Extracellular Matrix Calcification

(2009) R. C. Shroff et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sodium thiosulfate in the treatment of calcific uremic arteriolopathy

(2009) Georg Schlieper et al.   Nature Reviews Nephrology

Calcium balance in haemodialysis—do not lower the dialysate calcium concentration too much (con part)

(2009) Tilman B. Drüeke et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Pro/Con debate: the calculation on calcium balance in dialysis lowers the dialysate calcium concentrations (pro part)

(2009) Frank A. Gotch   NEPHROLOGY DIALYSIS TRANSPLANTATION

A 1-Year Randomized Trial of Calcium Acetate Versus Sevelamer on Progression of Coronary Artery Calcification in Hemodialysis Patients With Comparable Lipid Control: The Calcium Acetate Renagel Evaluation-2 (CARE-2) Study

(2008) Wajeh Qunibi et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells

(2008) Masih-ul Alam et al.   CARDIOVASCULAR RESEARCH

Chronic Apoptosis of Vascular Smooth Muscle Cells Accelerates Atherosclerosis and Promotes Calcification and Medial Degeneration

(2008) Murray C.H. Clarke et al.   CIRCULATION RESEARCH

Oxidative Stress Induces Vascular Calcification through Modulation of the Osteogenic Transcription Factor Runx2 by AKT Signaling

(2008) Chang Hyun Byon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY