Gut dysbiosis, leaky gut, and intestinal epithelial proliferation in neurological disorders: towards the development of a new therapeutic using amino acids, prebiotics, probiotics, and postbiotics

Oral sodium butyrate impacts brain metabolism and hippocampal neurogenesis, with limited effects on gut anatomy and function in pigs

(2018) David Val-Laillet et al.   FASEB JOURNAL

Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans

(2018) JACOB M. ALLEN et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Dietary fatty acids and susceptibility to multiple sclerosis

(2018) Stefanie Haase et al.   Multiple Sclerosis Journal

Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response

(2018) Giuseppe Faraco et al.   NATURE NEUROSCIENCE

Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

(2018) Chi Ma et al.   SCIENCE

An ingestible bacterial-electronic system to monitor gastrointestinal health

(2018) Mark Mimee et al.   SCIENCE

Maturation of the gut microbiome and risk of asthma in childhood

(2018) Jakob Stokholm et al.   Nature Communications

The Effect of Oligofructose-Enriched Inulin on Faecal Bacterial Counts and Microbiota-Associated Characteristics in Celiac Disease Children Following a Gluten-Free Diet: Results of a Randomized, Placebo-Controlled Trial

(2018) Natalia Drabińska et al.   Nutrients

Dietary fatty acids and susceptibility to multiple sclerosis

(2018) Stefanie Haase et al.   Multiple Sclerosis Journal

Gut microbiome populations are associated with structure-specific changes in white matter architecture

(2018) Irene M. Ong et al.   Translational Psychiatry

Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism

(2018) Shannon Rose et al.   Translational Psychiatry

High concentration of branched-chain amino acids promotes oxidative stress, inflammation and migration of human peripheral blood mononuclear cells via mTORC1 activation

(2017) Olha Zhenyukh et al.   FREE RADICAL BIOLOGY AND MEDICINE

A High-Cholesterol Diet Increases 27-Hydroxycholesterol and Modifies Estrogen Receptor Expression and Neurodegeneration in Rabbit Hippocampus

(2017) Sylwia W. Brooks et al.   JOURNAL OF ALZHEIMERS DISEASE

Shear stress induces noncanonical autophagy in intestinal epithelial monolayers

(2017) Sun Wook Kim et al.   MOLECULAR BIOLOGY OF THE CELL

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

(2017) Annamaria Cattaneo et al.   NEUROBIOLOGY OF AGING

The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril

(2017) Einav Tayeb-Fligelman et al.   SCIENCE

A bacterial global regulator forms a prion

(2017) Andy H. Yuan et al.   SCIENCE

Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation

(2017) Antonio Galleu et al.   Science Translational Medicine

Chickpea-supplemented diet alters the gut microbiome and enhances gut barrier integrity in C57Bl/6 male mice

(2017) Jennifer M. Monk et al.   Journal of Functional Foods

Gastric Emptying and Gastrointestinal Transit Compared among Native and Hydrolyzed Whey and Casein Milk Proteins in an Aged Rat Model

(2017) Julie Dalziel et al.   Nutrients

Dietary Green Pea Protects against DSS-Induced Colitis in Mice Challenged with High-Fat Diet

(2017) et al.   Nutrients

Intrinsic Autophagy Is Required for the Maintenance of Intestinal Stem Cells and for Irradiation-Induced Intestinal Regeneration

(2017) Jumpei Asano et al.   Cell Reports

16S rRNA Next Generation Sequencing Analysis Shows Bacteria in Alzheimer’s Post-Mortem Brain

(2017) David C. Emery et al.   Frontiers in Aging Neuroscience

A critical assessment of the “sterile womb” and “in utero colonization” hypotheses: implications for research on the pioneer infant microbiome

(2017) Maria Elisa Perez-Muñoz et al.   Microbiome

Amyotrophic lateral sclerosis as a protein level, non-genomic disease: Therapy with S2RM exosome released molecules

(2017) Greg Maguire   World Journal of Stem Cells

Let them eat fruit! The effect of fruit and vegetable consumption on psychological well-being in young adults: A randomized controlled trial

(2017) Tamlin S. Conner et al.   PLoS One

Premature senescence of endothelial cells upon chronic exposure to TNFα can be prevented by N-acetyl cysteine and plumericin

(2017) Shafaat Y. Khan et al.   Scientific Reports

Prevalence and antibiotic resistance ofEnterococcusstrains isolated from poultry

(2016) Dagmara Stępień-Pyśniak et al.   ACTA VETERINARIA HUNGARICA

Evolution of Well-Being and Happiness After Increases in Consumption of Fruit and Vegetables

(2016) Redzo Mujcic et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Oligosaccharides Released from Milk Glycoproteins Are Selective Growth Substrates for Infant-Associated Bifidobacteria

(2016) Sercan Karav et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

The Central Nervous System and the Gut Microbiome

(2016) Gil Sharon et al.   CELL

Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid  -Protein Oligomers

(2016) H. Xu et al.   JOURNAL OF NEUROSCIENCE

Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke

(2016) V. Singh et al.   JOURNAL OF NEUROSCIENCE

Global burden of stroke and risk factors in 188 countries, during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2016) Valery L Feigin et al.   LANCET NEUROLOGY

Living factories of the future

(2016) Michael Eisenstein   NATURE

Signals from the gut microbiota to distant organs in physiology and disease

(2016) Bjoern O Schroeder et al.   NATURE MEDICINE

Distinct prion-like strains of amyloid beta implicated in phenotypic diversity of Alzheimer's disease

(2016) Mark Cohen et al.   Prion

The plant component of an Acheulian diet at Gesher Benot Ya‘aqov, Israel

(2016) Yoel Melamed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of a gut pathobiont in a gnotobiotic mouse model of childhood undernutrition

(2016) V. E. Wagner et al.   Science Translational Medicine

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

Psychobiotics and the Manipulation of Bacteria–Gut–Brain Signals

(2016) Amar Sarkar et al.   TRENDS IN NEUROSCIENCES

The Prion-Like Properties of Amyloid-β Assemblies: Implications for Alzheimer's Disease

(2016) Lary C. Walker et al.   Cold Spring Harbor Perspectives in Medicine

The early infant gut microbiome varies in association with a maternal high-fat diet

(2016) Derrick M. Chu et al.   Genome Medicine

Association of Environmental Toxins With Amyotrophic Lateral Sclerosis

(2016) Feng-Chiao Su et al.   JAMA Neurology

Regulation of prefrontal cortex myelination by the microbiota

(2016) A E Hoban et al.   Translational Psychiatry

Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid

(2016) Maria Carmen Collado et al.   Scientific Reports

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease

(2016) Myles R. Minter et al.   Scientific Reports

An amino acid-based oral rehydration solution (AA-ORS) enhanced intestinal epithelial proliferation in mice exposed to radiation

(2016) Liangjie Yin et al.   Scientific Reports

Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans

(2016) Shu G. Chen et al.   Scientific Reports

Serotonin, tryptophan metabolism and the brain-gut-microbiome axis

(2015) S.M. O’Mahony et al.   BEHAVIOURAL BRAIN RESEARCH

A cell-free expression and purification process for rapid production of protein biologics

(2015) Challise J. Sullivan et al.   Biotechnology Journal

Exogenous α-synuclein induces toll-like receptor 4 dependent inflammatory responses in astrocytes

(2015) Emmy H. Rannikko et al.   BMC NEUROSCIENCE

Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour

(2015) Lieve Desbonnet et al.   BRAIN BEHAVIOR AND IMMUNITY

Age-associated modifications of intestinal permeability and innate immunity in human small intestine

(2015) Angela L. Man et al.   CLINICAL SCIENCE

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

(2015) Aiden Haghikia et al.   IMMUNITY

Neural circuitry and immunity

(2015) Valentin A. Pavlov et al.   IMMUNOLOGIC RESEARCH

Potential role of gut microbiota and tissue barriers in Parkinson's disease and amyotrophic lateral sclerosis

(2015) Xin Fang   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Long-Term Change in Diet Quality Is Associated with Body Weight Change in Men and Women

(2015) Teresa T Fung et al.   JOURNAL OF NUTRITION

Role of intestinal microbiota in the generation of polyphenol-derived phenolic acid mediated attenuation of Alzheimer's disease β-amyloid oligomerization

(2015) Dongjie Wang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome

(2015) Benoit Chassaing et al.   NATURE

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Mediterranean diet and brain structure in a multiethnic elderly cohort

(2015) Yian Gu et al.   NEUROLOGY

The “psychomicrobiotic”: Targeting microbiota in major psychiatric disorders: A systematic review

(2015) G. Fond et al.   PATHOLOGIE BIOLOGIE

Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress

(2015) Ali B. Rodgers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes released by keratinocytes modulate melanocyte pigmentation

(2015) Alessandra Lo Cicero et al.   Nature Communications

A cell-free expression and purification process for rapid production of protein biologics

(2015) Challise J. Sullivan et al.   Biotechnology Journal

Membrane vesicle-mediated release of bacterial RNA

(2015) Annika E. Sjöström et al.   Scientific Reports

Bile acids and the gut microbiome

(2014) Jason M. Ridlon et al.   CURRENT OPINION IN GASTROENTEROLOGY

Diet, Metabolites, and “Western-Lifestyle” Inflammatory Diseases

(2014) Alison N. Thorburn et al.   IMMUNITY

Four types ofBifidobacteriatrigger autophagy response in intestinal epithelial cells

(2014) Rong Lin et al.   Journal of Digestive Diseases

Plant foods and the dietary ecology of Neanderthals and early modern humans

(2014) Amanda G. Henry et al.   JOURNAL OF HUMAN EVOLUTION

Untold Nutrition

(2014) T. Colin Campbell   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Circadian Disorganization Alters Intestinal Microbiota

(2014) Robin M. Voigt et al.   PLoS One

Oral Microbiome Link to Neurodegeneration in Glaucoma

(2014) Konstantin Astafurov et al.   PLoS One

Intestinal dysbiosis: Novel mechanisms by which gut microbes trigger and prevent disease

(2014) Mark A. Underwood   PREVENTIVE MEDICINE

Epigenomic regulation of host–microbiota interactions

(2014) Theresa Alenghat et al.   TRENDS IN IMMUNOLOGY

Microbiota and neurodevelopmental windows: implications for brain disorders

(2014) Yuliya E. Borre et al.   TRENDS IN MOLECULAR MEDICINE

Gut microbiome of the Hadza hunter-gatherers

(2014) Stephanie L. Schnorr et al.   Nature Communications

Decreased Bacterial Diversity Characterizes the Altered Gut Microbiota in Patients With Psoriatic Arthritis, Resembling Dysbiosis in Inflammatory Bowel Disease

(2014) Jose U. Scher et al.   Arthritis & Rheumatology

N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities

(2014) Reza Bavarsad Shahripour et al.   Brain and Behavior

Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans

(2013) Junhai Ou et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The Ability of Bifidobacteria To Degrade Arabinoxylan Oligosaccharide Constituents and Derived Oligosaccharides Is Strain Dependent

(2013) Audrey Rivière et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Reprogramming Adult Schwann Cells to Stem Cell-like Cells by Leprosy Bacilli Promotes Dissemination of Infection

(2013) Toshihiro Masaki et al.   CELL

Exercise Attenuates PCB-Induced Changes in the Mouse Gut Microbiome

(2013) Jeong June Choi et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Consumption of Fermented Milk Product With Probiotic Modulates Brain Activity

(2013) Kirsten Tillisch et al.   GASTROENTEROLOGY

Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism

(2013) Tim Vanuytsel et al.   GUT

Summer Meeting 2013: growth and physiology of bifidobacteria

(2013) L. De Vuyst et al.   JOURNAL OF APPLIED MICROBIOLOGY

Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study

(2013) Dean Ornish et al.   LANCET ONCOLOGY

TcpC protein from E. coli Nissle improves epithelial barrier function involving PKCζ and ERK1/2 signaling in HT-29/B6 cells

(2013) N A Hering et al.   Mucosal Immunology

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Environmental Particulate Matter Induces Murine Intestinal Inflammatory Responses and Alters the Gut Microbiome

(2013) Lisa Kish et al.   PLoS One

High-Fat Diet Reduces the Formation of Butyrate, but Increases Succinate, Inflammation, Liver Fat and Cholesterol in Rats, while Dietary Fibre Counteracts These Effects

(2013) Greta Jakobsdottir et al.   PLoS One

Changing patterns of neurological mortality in the 10 major developed countries – 1979–2010

(2013) C. Pritchard et al.   PUBLIC HEALTH

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Molecular Characterization of Host-Specific Biofilm Formation in a Vertebrate Gut Symbiont

(2013) Steven A. Frese et al.   PLoS Genetics

Disease to Dirt: The Biology of Microbial Amyloids

(2013) David A. Hufnagel et al.   PLoS Pathogens

Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia

(2012) Ana Paula Boroni Moreira et al.   BRITISH JOURNAL OF NUTRITION

Epidemiologic studies of exposure to prenatal infection and risk of schizophrenia and autism

(2012) Alan S. Brown   Developmental Neurobiology

γ-Aminobutyric acid production by culturable bacteria from the human intestine

(2012) E. Barrett et al.   JOURNAL OF APPLIED MICROBIOLOGY

Breastfeeding is associated with lower risk for multiple sclerosis

(2012) Silja Conradi et al.   Multiple Sclerosis Journal

Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits

(2012) Penelope J. Hallett et al.   NEUROBIOLOGY OF DISEASE

Ageing of the human metaorganism: the microbial counterpart

(2011) Elena Biagi et al.   AGE

High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health

(2011) Wendy R Russell et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Dietary cholesterol: from physiology to cardiovascular risk

(2011) Jean-Michel Lecerf et al.   BRITISH JOURNAL OF NUTRITION

Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation

(2011) Ying Li et al.   CELL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Diesel Exhaust Activates and Primes Microglia: Air Pollution, Neuroinflammation, and Regulation of Dopaminergic Neurotoxicity

(2011) Shannon Levesque et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Cross-feeding between bifidobacteria and butyrate-producing colon bacteria explains bifdobacterial competitiveness, butyrate production, and gas production

(2011) Luc De Vuyst et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Air pollution: An environmental factor contributing to intestinal disease

(2011) Leigh A. Beamish et al.   Journal of Crohns & Colitis

Autophagy in Spinal Cord Motor Neurons in Sporadic Amyotrophic Lateral Sclerosis

(2011) Shoichi Sasaki   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Bifidobacteria can protect from enteropathogenic infection through production of acetate

(2011) Shinji Fukuda et al.   NATURE

Diets of modern hunter-gatherers vary substantially in their carbohydrate content depending on ecoenvironments: results from an ethnographic analysis

(2011) Alexander Ströhle et al.   NUTRITION RESEARCH

Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice

(2011) Ece A Mutlu et al.   Particle and Fibre Toxicology

Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease

(2011) Christopher B. Forsyth et al.   PLoS One

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

(2011) J. A. Bravo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic Transmission of the Impact of Early Stress Across Generations

(2010) Tamara B. Franklin et al.   BIOLOGICAL PSYCHIATRY

Intake of Added Sugars and Selected Nutrients in the United States, National Health and Nutrition Examination Survey (NHANES) 2003—2006

(2010) Bernadette P. Marriott et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Murine Cecal Patch M Cells Transport Infectious Prions In Vivo

(2010) Neil Foster et al.   JOURNAL OF INFECTIOUS DISEASES

Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils

(2010) Marco A.R. Vinolo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Systemic inflammatory cells fight off neurodegenerative disease

(2010) Michal Schwartz et al.   Nature Reviews Neurology

Modulation of natural immunity in the gut by Escherichia coli strain Nissle 1917

(2010) Ilja Trebichavsky et al.   NUTRITION REVIEWS

Increased Prevalence and Mortality in Undiagnosed Celiac Disease

(2009) Alberto Rubio–Tapia et al.   GASTROENTEROLOGY

Air pollution: mechanisms of neuroinflammation and CNS disease

(2009) Michelle L. Block et al.   TRENDS IN NEUROSCIENCES

A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome

(2009) A Venket Rao et al.   Gut Pathogens

In Vitro Kinetic Analysis of Fermentation of Prebiotic Inulin-Type Fructans by Bifidobacterium Species Reveals Four Different Phenotypes

(2008) G. Falony et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cytokine regulation of tight junctions

(2008) Christopher T. Capaldo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Gum arabic establishes prebiotic functionality in healthy human volunteers in a dose-dependent manner

(2008) Wim Calame et al.   BRITISH JOURNAL OF NUTRITION

Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: Potential implications for disease

(2008) V. Padler-Karavani et al.   GLYCOBIOLOGY

A comprehensive review on salt and health and current experience of worldwide salt reduction programmes

(2008) F J He et al.   JOURNAL OF HUMAN HYPERTENSION

Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)

(2008) Rongzhen Zhang et al.   JOURNAL OF NEUROIMMUNOLOGY

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Exposure to diesel exhaust induces changes in EEG in human volunteers

(2008) Bjoern Cruts et al.   Particle and Fibre Toxicology