Article
Biochemistry & Molecular Biology
Braden T. Tierney, Yingxuan Tan, Zhen Yang, Bing Shui, Michaela J. Walker, Benjamin M. Kent, Aleksandar D. Kostic, Chirag J. Patel
Summary: This study evaluated the consistency and robustness of the relationship between the human gut microbiome and disease using various association modeling strategies. The results showed that different models can yield contradictory associations for the same microbe-disease pairing. Furthermore, previous reports on microbe-disease associations demonstrated substantial inconsistency in association sign, particularly for type 1 and type 2 diabetes. The study also analyzed the influence of potential confounders on the associations.
Review
Gastroenterology & Hepatology
Karolina Kazmierczak-Siedlecka, Karolina Skonieczna-Zydecka, Theodore Hupp, Renata Duchnowska, Natalia Marek-Trzonkowska, Karol Polom
Summary: The gut microbiota has been extensively studied in relation to cancer development and treatment. Next-generation probiotics (NGPs) are being increasingly explored as therapeutic agents that can alter the gut microbiota and impact cancer development. This review focuses on three emerging NGPs – Faecalibacterium prausnitzii, Akkermansia muciniphila, and Bacteroides fragilis – which have been found to have an impact on cancer incidence. These NGPs enhance gastrointestinal immunity, maintain intestinal barrier integrity, produce beneficial metabolites, act against pathogens, improve immunotherapy efficacy, and reduce complications associated with chemotherapy and radiotherapy. While the safety of NGPs in cancer patients is still relatively unclear, recent data has shown that they are non-toxigenic. Overall, the use of NGPs shows promise in preventing cancer development and providing new therapeutic options for cancer patients.
Article
Chemistry, Medicinal
Hye Rim Byeon, Seo-Yul Jang, Yoonmi Lee, Dohak Kim, Moon-Gi Hong, Dokyung Lee, Joo-Hyun Shin, Jae-Gu Seo
Summary: In this study, the efficacy of A. muciniphila and F. prausnitzii strains in a mouse model of muscular atrophy was evaluated. The results showed that these strains improved grip strength, decreased the expression of ubiquitin-proteasome genes, increased the expression of the mitochondrial biogenesis regulatory gene, and modulated immune function. These findings suggest the potential beneficial effects of A. muciniphila and F. prausnitzii as next-generation probiotics for muscular atrophy.
JOURNAL OF MEDICINAL FOOD
(2022)
Review
Biochemistry & Molecular Biology
Francesca De Filippis, Alessia Esposito, Danilo Ercolini
Summary: Currently available probiotics are limited in microbial species, but recent research suggests that the gut microbiome holds potential for beneficial microbes. Researchers are focusing on identifying and testing new gut-origin microbial strains for the development of next-generation probiotics. While some of these strains show promise for preventing and treating chronic diseases, human studies are lacking and regulatory approval is rare. Furthermore, challenges remain in cultivation and storage methods for oxygen-sensitive bacteria before wide market application.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Rezvan Yaghoubfar, Ava Behrouzi, Ehsan Zare Banadkoki, Fatemeh Ashrafian, Arezou Lari, Farzam Vaziri, Seyed Ali Nojoumi, Abolfazl Fateh, Shohreh Khatami, Seyed Davar Siadat
Summary: Akkermansia muciniphila and Faecalibacterium prausnitzii along with their extracellular vesicles can increase serotonin levels in colorectal adenocarcinoma cells and significantly impact the expression of genes related to the serotonin system.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Multidisciplinary Sciences
Muhammad Tanweer Khan, Chinmay Dwibedi, Daniel Sundh, Meenakshi Pradhan, Jamie D. Kraft, Robert Caesar, Valentina Tremaroli, Mattias Lorentzon, Fredrik Backhed
Summary: This study successfully co-isolated Faecalibacterium prausnitzii and Desulfovibrio piger and identified their symbiotic relationship in growth and butyrate production. By adapting Faecalibacterium prausnitzii to tolerate oxygen exposure, researchers developed a next-generation probiotic formulation.
Article
Integrative & Complementary Medicine
Motahare Mokhtarzade, Mahdieh Molanouri Shamsi, Maryam Abolhasani, Bita Bakhshi, Mohammad Ali Sahraian, LeBris S. Quinn, Raoof Negaresh
Summary: Home-based exercise has a significant impact on gut bacteria in people with multiple sclerosis, particularly on prevotella and akkermansia muciniphila counts, which may benefit MS disease pathology and course. However, the lack of changes in circulating cytokine levels following exercise suggests the involvement of mechanisms other than modulation of IL-10 and TNF-alpha levels.
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2021)
Review
Microbiology
Mingxia Bi, Chang Liu, Yulin Wang, Shuang-Jiang Liu
Summary: Increasing evidence suggests that dysbiosis of the gut microbiome (GM) plays a key role in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. The gut-brain axis, which modulates central nervous system function, has gained significant interest in understanding the pathogenesis of these diseases. The development of new probiotics, such as Clostridium butyricum, Akkermansia muciniphila, Faecalibacterium prausnitzii, and Bacteroides fragilis, holds promise for the treatment of neurodegenerative disorders.
Article
Biology
L. Berbert, A. Santos, D. O. Magro, D. Guadagnini, H. B. Assalin, L. H. Lourenco, C. A. R. Martinez, M. J. A. Saad, C. S. R. Coy
Summary: This study investigated the composition of gut microbiota in Brazilian colorectal adenocarcinoma (CRC) patients compared with a control population. The results showed that CRC patients had increased alpha diversity, higher percentage of Prevotella genus, and decreased proportion of Megamonas and Ruminococcus. Faecalibacterium prausnitzii was associated with a better prognosis in early stages of CRC, while Fusobacterium nucleatum was identified as an important marker of colorectal carcinogenesis and tumor aggressiveness.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Musfiqur Sazal, Vitalii Stebliankin, Kalai Mathee, Changwon Yoo, Giri Narasimhan
Summary: Causal inference in biomedical research is crucial for understanding causal relationships in biological processes. A novel pipeline for microbiome analysis has been proposed to identify disease-relevant causal factors. The results have been validated using synthetic and real data sets, confirming the effectiveness of the approach.
SCIENTIFIC REPORTS
(2021)
Review
Microbiology
Lara Kern, Denise Kviatcovsky, Yiming He, Eran Elinav
Summary: The impact of restrictive diets on gut microbiota composition and function, as well as their overall influences on host health and disease risk, are discussed. The evidence of long-term efficacy, adverse effects, and mechanisms of activity of caloric restriction and related diets is currently incomplete.
CURRENT OPINION IN MICROBIOLOGY
(2023)
Article
Microbiology
Lirong Bao, Cheng Zhang, Jinglu Lyu, Caixia Yan, Ranran Cao, Ming Pan, Yan Li
Summary: Pharyngeal F. n was significantly increased in COVID-19 patients, particularly in males. Increased abundance of pharyngeal F. n was associated with a higher risk of a positive SARS-CoV-2 test, making it a promising candidate indicator for COVID-19.
Review
Food Science & Technology
Yining Chen, Maninder Meenu, Baojun Xu
Summary: This review summarizes the microencapsulation of obligate anaerobe Bifidobacterium and seeks out the optimal encapsulating methods for strictly anaerobic microbes-next-generation probiotics. Studies on the microencapsulation of strictly anaerobic bacteria, especially Bifidobacterium, Akkermansia muciniphila and Faecalibacterium prausnitzii, in the last 5 years have been reviewed in terms of encapsulants, techniques for microencapsulation, the viability of probiotics during storage, and their stability in the gastrointestinal tract.
FOOD REVIEWS INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Julian Herrera-Mejia, Rocio Campos-Vega, Abraham Wall-Medrano, Florinda Jimenez-Vega
Summary: Many neurological disorders, especially autism spectrum disorders (ASD), have distinct colonic microbiome signatures. Previous knowledge on this matter was obtained through high-throughput sequencing methods. This study used a sensitive two-step PCR protocol to differentiate colonic microbiome biomarkers in stool samples from ASD and neurotypical individuals.
Review
Microbiology
Raden Mohamad Rendy Ariezal Effendi, Muhammad Anshory, Handono Kalim, Reiva Farah Dwiyana, Oki Suwarsa, Luba M. Pardo, Tamar E. C. Nijsten, Hok Bing Thio
Summary: Probiotics and synbiotics are beneficial for treating chronic illnesses by modulating the immune system and reducing inflammation. Akkermansia muciniphila (A. muciniphila) and Faecalibacterium prausnitzii (F. prausnitzii) are two bacterial species that play significant roles in this process, promoting digestive health and enhancing the immune system, metabolism, and gut barrier function. They have the potential to be targeted in the treatment of microbiota-related diseases, such as immunological disorders and cancer immunotherapy. This review aims to provide an overview of the anti-inflammatory effects of Akkermansia and Faecalibacterium, particularly in immunological diseases, and explore their potential as microbiome-targeted therapies.
