Shear stress induces noncanonical autophagy in intestinal epithelial monolayers

Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine

(2017) Shai Bel et al.   SCIENCE

A switch from canonical to noncanonical autophagy shapes B cell responses

(2017) Nuria Martinez-Martin et al.   SCIENCE

Myosin-7b Promotes Distal Tip Localization of the Intermicrovillar Adhesion Complex

(2016) Meredith L. Weck et al.   CURRENT BIOLOGY

ANKS4B Is Essential for Intermicrovillar Adhesion Complex Formation

(2016) Scott W. Crawley et al.   DEVELOPMENTAL CELL

Mechanistic Basis of Organization of the Harmonin/USH1C-Mediated Brush Border Microvilli Tip-Link Complex

(2016) Jianchao Li et al.   DEVELOPMENTAL CELL

Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy

(2016) Tomonori Kimura et al.   EMBO JOURNAL

LC3/GABARAP family proteins: autophagy-(un)related functions

(2016) Marco B. E. Schaaf et al.   FASEB JOURNAL

Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann–Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease

(2016) Tobias Schwerd et al.   GUT

Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

(2016) Jennifer Martinez et al.   NATURE

Primary-cilium-dependent autophagy controls epithelial cell volume in response to fluid flow

(2016) Idil Orhon et al.   NATURE CELL BIOLOGY

Communications between Mitochondria, the Nucleus, Vacuoles, Peroxisomes, the Endoplasmic Reticulum, the Plasma Membrane, Lipid Droplets, and the Cytosol during Yeast Chronological Aging

(2016) Pamela Dakik et al.   Frontiers in Genetics

Cytometry-based single-cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF- -induced apoptosis in vivo

(2015) A. J. Simmons et al.   Molecular Systems Biology

Salmonellae interactions with host processes

(2015) Doris L. LaRock et al.   NATURE REVIEWS MICROBIOLOGY

VAMP4 Is an Essential Cargo Molecule for Activity-Dependent Bulk Endocytosis

(2015) Jessica C. Nicholson-Fish et al.   NEURON

Fluid shear triggers microvilli formation via mechanosensitive activation of TRPV6

(2015) Shigenori Miura et al.   Nature Communications

Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification

(2015) Caroline Mauvezin et al.   Nature Communications

Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential

(2015) Santosh Chauhan et al.   Nature Communications

A Role for Macro-ER-Phagy in ER Quality Control

(2015) Zhanna Lipatova et al.   PLoS Genetics

Neuronal glycogen synthesis contributes to physiological aging

(2014) Christopher Sinadinos et al.   AGING CELL

V-ATPase and osmotic imbalances activate endolysosomal LC3 lipidation

(2014) Oliver Florey et al.   Autophagy

Intestinal Brush Border Assembly Driven by Protocadherin-Based Intermicrovillar Adhesion

(2014) Scott W. Crawley et al.   CELL

Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease

(2014) Byron C. Knowles et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrating the active process of hair cells with cochlear function

(2014) A. J. Hudspeth   NATURE REVIEWS NEUROSCIENCE

Mpl Traffics to the Cell Surface Through Conventional and Unconventional Routes

(2014) Cédric Cleyrat et al.   TRAFFIC

Endocytosis and Autophagy: Exploitation or Cooperation?

(2014) S. A. Tooze et al.   Cold Spring Harbor Perspectives in Biology

Neonatal Immune Adaptation of the Gut and Its Role during Infections

(2013) Emilie Tourneur et al.   Clinical & Developmental Immunology

Genetic Variants Synthesize to Produce Paneth Cell Phenotypes That Define Subtypes of Crohn's Disease

(2013) Kelli L. VanDussen et al.   GASTROENTEROLOGY

Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α

(2013) Ken S. Lau et al.   Integrative Biology

Autophagy and microtubules - new story, old players

(2013) R. Mackeh et al.   JOURNAL OF CELL SCIENCE

Autophagosomes contribute to intracellular lipid distribution in enterocytes

(2013) Salem Ait Khaldoun et al.   MOLECULAR BIOLOGY OF THE CELL

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

The autophagosome: origins unknown, biogenesis complex

(2013) Christopher A. Lamb et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of a membrane trafficking protein αSNAP induces non-canonical autophagy in human epithelia

(2012) Nayden G. Naydenov et al.   CELL CYCLE

The role of autophagy in the pathogenesis of glycogen storage disease type II (GSDII)

(2012) A C Nascimbeni et al.   CELL DEATH AND DIFFERENTIATION

Blocked Autophagy Using Lysosomotropic Agents Sensitizes Resistant Prostate Tumor Cells to the Novel Akt Inhibitor AZD5363

(2012) F. Lamoureux et al.   CLINICAL CANCER RESEARCH

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Therapeutic targets in cancer cell metabolism and autophagy

(2012) Heesun Cheong et al.   NATURE BIOTECHNOLOGY

Multi-Scale In Vivo Systems Analysis Reveals the Influence of Immune Cells on TNF-α-Induced Apoptosis in the Intestinal Epithelium

(2012) Ken S. Lau et al.   PLOS BIOLOGY

Rescue of ΔF508-CFTR Trafficking via a GRASP-Dependent Unconventional Secretion Pathway

(2011) Heon Yung Gee et al.   CELL

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

Autophagy, Microbial Sensing, Endoplasmic Reticulum Stress, and Epithelial Function in Inflammatory Bowel Disease

(2011) Arthur Kaser et al.   GASTROENTEROLOGY

Cdx2 Controls Expression of the Protocadherin Mucdhl, an Inhibitor of Growth and β-Catenin Activity in Colon Cancer Cells

(2011) Isabelle Hinkel et al.   GASTROENTEROLOGY

Crohn's disease: NOD2, autophagy and ER stress converge

(2011) T. Fritz et al.   GUT

Transport phenomena of microbial flora in the small intestine with peristalsis

(2011) T. Ishikawa et al.   JOURNAL OF THEORETICAL BIOLOGY

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Canonical and non-canonical autophagy: variations on a common theme of self-eating?

(2011) Patrice Codogno et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

Blimp1 regulates the transition of neonatal to adult intestinal epithelium

(2011) Vanesa Muncan et al.   Nature Communications

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

The regulation of autophagy - unanswered questions

(2010) Y. Chen et al.   JOURNAL OF CELL SCIENCE

Plasma membrane contributes to the formation of pre-autophagosomal structures

(2010) Brinda Ravikumar et al.   NATURE CELL BIOLOGY

The origin of the autophagosomal membrane

(2010) Sharon A. Tooze et al.   NATURE CELL BIOLOGY

Early endosomes and endosomal coatomer are required for autophagy

(2009) Minoo Razi et al.   JOURNAL OF CELL BIOLOGY

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ganglioside composition of differentiated Caco-2 cells resembles human colostrum and neonatal rat intestine

(2008) Kareena L. Schnabl et al.   BRITISH JOURNAL OF NUTRITION

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression

(2008) Asako Sakaue-Sawano et al.   CELL

Physical characteristics of digesta and their influence on flow and mixing in the mammalian intestine: a review

(2008) R. G. Lentle et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS