Activation of Nrf2 target enzymes conferring protection against oxidative stress in PC12 cells by ginger principal constituent 6-shogaol

Xanthohumol, a Polyphenol Chalcone Present in Hops, Activating Nrf2 Enzymes To Confer Protection against Oxidative Damage in PC12 Cells

(2015) Juan Yao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Synthesis of Piperlongumine Analogues and Discovery of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators as Potential Neuroprotective Agents

(2015) Shoujiao Peng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Xanthohumol Analogues and Discovery of Potent Thioredoxin Reductase Inhibitor as Potential Anticancer Agent

(2015) Baoxin Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective Selenol Fluorescent Probes: Design, Synthesis, Structural Determinants, and Biological Applications

(2015) Baoxin Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dual protection of hydroxytyrosol, an olive oil polyphenol, against oxidative damage in PC12 cells

(2015) Shoujiao Peng et al.   Food & Function

Neuroprotective effect of ginger in the brain of streptozotocin-induced diabetic rats

(2014) Gehan El-Akabawy et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia

(2014) Minho Moon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ginger Compound [6]-Shogaol and Its Cysteine-Conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo

(2014) Huadong Chen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Influence of side chain structure changes on antioxidant potency of the [6]-gingerol related compounds

(2014) Dong-Liang Lu et al.   FOOD CHEMISTRY

Shikonin targets cytosolic thioredoxin reductase to induce ROS-mediated apoptosis in human promyelocytic leukemia HL-60 cells

(2014) Dongzhu Duan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of the Phase II Enzymes for Neuroprotection by Ginger Active Constituent 6-Dehydrogingerdione in PC12 Cells

(2014) Juan Yao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Dithiaarsanes Induce Oxidative Stress-Mediated Apoptosis in HL-60 Cells by Selectively Targeting Thioredoxin Reductase

(2014) Yaping Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Synthesis and molecular modeling study of Cu(II) complexes derived from 2-(diphenylmethylene)hydrazinecarbothioamide derivatives with cholinesterase inhibitory activities

(2013) Yi Chen Chan et al.   CHINESE CHEMICAL LETTERS

Thiol/disulfide redox states in signaling and sensing

(2013) Young-Mi Go et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs

(2013) Takumi Satoh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Keap Calm, and Carry on Covalently

(2013) Anthony J. Wilson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Target- and Mechanism-Based Therapeutics for Neurodegenerative Diseases: Strength in Numbers

(2013) Paul C. Trippier et al.   JOURNAL OF MEDICINAL CHEMISTRY

Highly Selective Off–On Fluorescent Probe for Imaging Thioredoxin Reductase in Living Cells

(2013) Liangwei Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

BG-12 in Multiple Sclerosis

(2013) Robert Fox et al.   SEMINARS IN NEUROLOGY

A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways

(2013) Fei-Fei Gan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe)

(2013) Raghavendra Haniadka et al.   Food & Function

The Predicted Molecular Weight of Nrf2: It Is What It Is Not

(2012) Alexandria Lau et al.   ANTIOXIDANTS & REDOX SIGNALING

An Impression on Current Developments in the Technology, Chemistry, and Biological Activities of Ginger (Zingiber officinaleRoscoe)

(2012) I. Rahath Kubra et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Ginger in the Prevention of Nausea and Vomiting: A Review

(2012) Princy Louis Palatty et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin

(2012) Feng Li et al.   FOOD CHEMISTRY

Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents

(2012) Sadagopan Magesh et al.   MEDICINAL RESEARCH REVIEWS

6-Shogaol-Rich Extract from Ginger Up-Regulates the Antioxidant Defense Systems in Cells and Mice

(2012) Min-Ji Bak et al.   MOLECULES

6-Shogaol, a ginger product, modulates neuroinflammation: A new approach to neuroprotection

(2012) Sang Keun Ha et al.   NEUROPHARMACOLOGY

A selective and sensitive fluorescence probe for imaging endogenous zinc in living cells

(2012) Liangwei Zhang et al.   TETRAHEDRON

Curcumin targeting the thioredoxin system elevates oxidative stress in HeLa cells

(2012) Wenqing Cai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Radioprotective effects of Zingiber officinale Roscoe (Ginger): past, present and future

(2012) Manjeshwar Shrinath Baliga et al.   Food & Function

Shogaols at proapoptotic concentrations induce G2/M arrest and aberrant mitotic cell death associated with tubulin aggregation

(2011) Fei-Fei Gan et al.   APOPTOSIS

Anti-inflammatory effects of [6]-shogaol: Potential roles of HDAC inhibition and HSP70 induction

(2011) Sehwan Shim et al.   FOOD AND CHEMICAL TOXICOLOGY

Small molecule inhibitors of mammalian thioredoxin reductase

(2011) Wenqing Cai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuroprotective effect of ginger on anti-oxidant enzymes in streptozotocin-induced diabetic rats

(2010) Kondeti Ramudu Shanmugam et al.   FOOD AND CHEMICAL TOXICOLOGY

Quantitative Analysis of Ginger Components in Commercial Products Using Liquid Chromatography with Electrochemical Array Detection

(2010) Xi Shao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Nutraceutical Antioxidants as Novel Neuroprotective Agents

(2010) Natalie A. Kelsey et al.   MOLECULES

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

(2009) Bayani Uttara et al.   Current Neuropharmacology

Thiol Chemistry in Peroxidase Catalysis and Redox Signaling

(2008) Alberto Bindoli et al.   ANTIOXIDANTS & REDOX SIGNALING

The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease

(2008) Marcus J. Calkins et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2-induced antioxidant protection: A promising target to counteract ROS-mediated damage in neurodegenerative disease?

(2008) Helga E. de Vries et al.   FREE RADICAL BIOLOGY AND MEDICINE

Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research

(2007) Badreldin H. Ali et al.   FOOD AND CHEMICAL TOXICOLOGY