Modeling the Positive Symptoms of Schizophrenia in Genetically Modified Mice: Pharmacology and Methodology Aspects

Mice mutant for genes associated with schizophrenia: Common phenotype or distinct endophenotypes?

(2009) Lieve Desbonnet et al.   BEHAVIOURAL BRAIN RESEARCH

Prepulse inhibition and genetic mouse models of schizophrenia

(2009) Susan B. Powell et al.   BEHAVIOURAL BRAIN RESEARCH

Role of serotonin-1A receptors in the action of antipsychotic drugs: comparison of prepulse inhibition studies in mice and rats and relevance for human pharmacology

(2009) Andrea Gogos et al.   BEHAVIOURAL PHARMACOLOGY

Mutant models for genes associated with schizophrenia

(2009) Lieve Desbonnet et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Gender-Specific Impact of Brain-Derived Neurotrophic Factor Signaling on Stress-Induced Depression-Like Behavior

(2009) Anita E. Autry et al.   BIOLOGICAL PSYCHIATRY

Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

(2009) Yingwei Mao et al.   CELL

Neurobehavioral abnormalities in the dysbindin-1 mutant, sandy, on a C57BL/6J genetic background

(2009) M. M. Cox et al.   GENES BRAIN AND BEHAVIOR

Neuregulin 1 hypomorphic mutant mice: enhanced baseline locomotor activity but normal psychotropic drug-induced hyperlocomotion and prepulse inhibition regulation

(2009) Maarten van den Buuse et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

5-HT2A and 5-HT2C Receptors Exert Opposing Effects on Locomotor Activity in Mice

(2009) Adam L Halberstadt et al.   NEUROPSYCHOPHARMACOLOGY

Behavioral profile of a heterozygous mutant mouse model for EGF-like domain neuregulin 1.

(2008) Liesl Duffy et al.   BEHAVIORAL NEUROSCIENCE

Generation and behavioral characterization of β-catenin forebrain-specific conditional knock-out mice

(2008) Todd D. Gould et al.   BEHAVIOURAL BRAIN RESEARCH

Behavioral characterization of dysbindin-1 deficient sandy mice

(2008) Sanjeev K. Bhardwaj et al.   BEHAVIOURAL BRAIN RESEARCH

Glycogen synthase kinase-3?? heterozygote knockout mice as a model of findings in postmortem schizophrenia brain or as a model of behaviors mimicking lithium action: negative results

(2008) Yuly Bersudsky et al.   BEHAVIOURAL PHARMACOLOGY

Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia

(2008) Satoko Hattori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Loss of Glial Glutamate and Aspartate Transporter (Excitatory Amino Acid Transporter 1) Causes Locomotor Hyperactivity and Exaggerated Responses to Psychotomimetics: Rescue by Haloperidol and Metabotropic Glutamate 2/3 Agonist

(2008) Rose-Marie Karlsson et al.   BIOLOGICAL PSYCHIATRY

The acute effects of NMDA antagonism: From the rodent to the human brain

(2008) Handan Gunduz-Bruce   BRAIN RESEARCH REVIEWS

Candidate genes and the behavioral phenotype in 22q11.2 deletion syndrome

(2008) Sarah E. Prasad et al.   Developmental Disabilities Research Reviews

Heterozygous reeler mice exhibit alterations in sensorimotor gating but not presynaptic proteins

(2008) Alasdair M. Barr et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neuregulin-1 signaling in schizophrenia: ‘Jack of all trades’ or master of some?

(2008) Colm MP O’Tuathaigh et al.   Expert Review of Neurotherapeutics

Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice

(2008) M. A. Kelly et al.   GENES BRAIN AND BEHAVIOR

Amphetamine-induced locomotion and gene expression are altered in BDNF heterozygous mice

(2008) A. J. Saylor et al.   GENES BRAIN AND BEHAVIOR

Behavioral characterization of mice lacking the neurite outgrowth inhibitor Nogo-A

(2008) R. Willi et al.   GENES BRAIN AND BEHAVIOR

Clozapine reverses schizophrenia-related behaviours in the metabotropic glutamate receptor 5 knockout mouse: association with N-methyl-d-aspartic acid receptor up-regulation

(2008) Laura Gray et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

DTNBP1, a schizophrenia susceptibility gene, affects kinetics of transmitter release

(2008) Xiao-Wei Chen et al.   JOURNAL OF CELL BIOLOGY

Muscarinic receptors: do they have a role in the pathology and treatment of schizophrenia?

(2008) Elizabeth Scarr et al.   JOURNAL OF NEUROCHEMISTRY

Genetic Dissection of the Role of Catechol-O-Methyltransferase in Cognition and Stress Reactivity in Mice

(2008) F. Papaleo et al.   JOURNAL OF NEUROSCIENCE

Type III Neuregulin-1 Is Required for Normal Sensorimotor Gating, Memory-Related Behaviors, and Corticostriatal Circuit Components

(2008) Y.-J. J. Chen et al.   JOURNAL OF NEUROSCIENCE

Evidence for the Role of Metabotropic Glutamate (mGlu)2 Not mGlu3 Receptors in the Preclinical Antipsychotic Pharmacology of the mGlu2/3 Receptor Agonist (-)-(1R,4S,5S,6S)-4-Amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic Acid (LY404039)

(2008) M. J. Fell et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Review: The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia

(2008) PJ Harrison et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Looking at Lithium: Molecular Moods and Complex Behaviour

(2008) J.-M. Beaulieu et al.   MOLECULAR INTERVENTIONS

Developmental etiology for neuroanatomical and cognitive deficits in mice overexpressing Gαs, a G-protein subunit genetically linked to schizophrenia

(2008) M P Kelly et al.   MOLECULAR PSYCHIATRY

Oxytocin as a natural antipsychotic: a study using oxytocin knockout mice

(2008) H K Caldwell et al.   MOLECULAR PSYCHIATRY

Neuregulin 1 in neural development, synaptic plasticity and schizophrenia

(2008) Lin Mei et al.   NATURE REVIEWS NEUROSCIENCE

Assessment of Glutamate Transporter GLAST (EAAT1)-Deficient Mice for Phenotypes Relevant to the Negative and Executive/Cognitive Symptoms of Schizophrenia

(2008) Rose-Marie Karlsson et al.   NEUROPSYCHOPHARMACOLOGY

Genetic Disruption of Both Tryptophan Hydroxylase Genes Dramatically Reduces Serotonin and Affects Behavior in Models Sensitive to Antidepressants

(2008) Katerina V. Savelieva et al.   PLoS One

Deficiency of Aph1B/C- -secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment

(2008) T. Dejaegere et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional disturbances in the striatum by region-specific ablation of NMDA receptors

(2008) N. Ohtsuka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

(2008) A. V. Savonenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition

(2008) M. Kvajo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of GSK3  in behavioral abnormalities induced by serotonin deficiency

(2008) J.-M. Beaulieu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effect of early maternal separation on brain derived neurotrophic factor and monoamine levels in adult heterozygous reeler mice

(2008) Elisa Ognibene et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Comparison of dopamine D1 and D5 receptor knockout mice for cocaine locomotor sensitization

(2008) Rose-Marie Karlsson et al.   PSYCHOPHARMACOLOGY

Genetic Research in Schizophrenia: New Tools and Future Perspectives

(2008) L. Bertram   SCHIZOPHRENIA BULLETIN

Dysbindin deficiency in sandy mice causes reduction of snapin and displays behaviors related to schizophrenia

(2008) Y FENG et al.   SCHIZOPHRENIA RESEARCH

Glutamate receptor mGlu2 and mGlu3 knockout striata are dopamine supersensitive, with elevated D2Highreceptors and marked supersensitivity to the dopamine agonist (+)PHNO

(2008) Philip Seeman et al.   SYNAPSE

Disrupted-in-Schizophrenia-1

(2008) Walter J. Muir et al.   Current Psychiatry Reports

Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia

(2008) Keizo Takao et al.   Molecular Brain

Contribution of Methylenetetrahydrofolate Reductase (MTHFR) Polymorphisms to Negative Symptoms in Schizophrenia

(2007) Joshua L. Roffman et al.   BIOLOGICAL PSYCHIATRY

Inactivation of the 5-HT7 Receptor Partially Blocks Phencyclidine-Induced Disruption of Prepulse Inhibition

(2007) Svetlana Semenova et al.   BIOLOGICAL PSYCHIATRY