Resistance to antibiotics targeted to the bacterial cell wall

Structure of Enterococcus faeciuml,d-Transpeptidase Acylated by Ertapenem Provides Insight into the Inactivation Mechanism

(2013) Lauriane Lecoq et al.   ACS Chemical Biology

Structural Analysis of the Role of Pseudomonas aeruginosa Penicillin-Binding Protein 5 in β-Lactam Resistance

(2013) Jeffrey D. Smith et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of Druggable Targets for Acinetobacter baumannii Via Subtractive Genomics and Plausible Inhibitors for MurA and MurB

(2013) Navkiran Kaur et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Mechanistic studies of FosB: a divalent-metal-dependent bacillithiol-S-transferase that mediates fosfomycin resistance inStaphylococcus aureus

(2013) Alexandra A. Roberts et al.   BIOCHEMICAL JOURNAL

Structural and Chemical Aspects of Resistance to the Antibiotic Fosfomycin Conferred by FosB from Bacillus cereus

(2013) Matthew K. Thompson et al.   BIOCHEMISTRY

Investigational Antimicrobial Agents of 2013

(2013) M. J. Pucci et al.   CLINICAL MICROBIOLOGY REVIEWS

MreB and MurG as scaffolds for the cytoplasmic steps of peptidoglycan biosynthesis

(2013) Sandy Favini-Stabile et al.   ENVIRONMENTAL MICROBIOLOGY

Kinetic mechanism and inhibition ofMycobacterium tuberculosisd-alanine:d-alanine ligase by the antibioticd-cycloserine

(2013) Gareth A. Prosser et al.   FEBS Journal

Telavancin versus vancomycin for bacteraemic hospital-acquired pneumonia

(2013) Martin E. Stryjewski et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Characterization of Escherichia coli D-Cycloserine Transport and Resistant Mutants

(2013) G. Baisa et al.   JOURNAL OF BACTERIOLOGY

Molecular dynamics simulation and linear interaction energy study of d-Glu-based inhibitors of the MurD ligase

(2013) Andrej Perdih et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Inhibitory Mechanism of Novel Inhibitors of UDP-N-Acetylglucosamine Enolpyruvyl Transferase from Haemophilus influenzae

(2013) Bong-Suk Jin   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

The Efflux Inhibitor Phenylalanine-Arginine Beta-Naphthylamide (PAβN) Permeabilizes the Outer Membrane of Gram-Negative Bacteria

(2013) Ryan P. Lamers et al.   PLoS One

Kinetic Features of L,D-Transpeptidase Inactivation Critical for β-Lactam Antibacterial Activity

(2013) Sébastien Triboulet et al.   PLoS One

Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus

(2013) J. S. Edwards et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis

(2013) B. C. Chung et al.   SCIENCE

Structure of MurA (UDP-N-acetylglucosamine enolpyruvyl transferase) fromVibrio fischeriin complex with substrate UDP-N-acetylglucosamine and the drug fosfomycin

(2012) D. C. Bensen et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Viable screening targets related to the bacterial cell wall

(2012) Lynn L. Silver   Annals of the New York Academy of Sciences

Metallo-β-lactamase structure and function

(2012) Timothy Palzkill   Annals of the New York Academy of Sciences

Bacterial cell-wall recycling

(2012) Jarrod W. Johnson et al.   Annals of the New York Academy of Sciences

Structural Perspective of Peptidoglycan Biosynthesis and Assembly

(2012) Andrew L. Lovering et al.   Annual Review of Biochemistry

Different Biosynthetic Pathways to Fosfomycin in Pseudomonas syringae and Streptomyces Species

(2012) Seung Young Kim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Oritavancin: Mechanism of Action

(2012) George G. Zhanel et al.   CLINICAL INFECTIOUS DISEASES

Molecular mechanisms of β-lactam resistance inStreptococcus pneumoniae

(2012) Regine Hakenbeck et al.   Future Microbiology

The 2012 Garrod Lecture: Discovery of antibacterial drugs in the 21st century

(2012) I. Chopra   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Structural and Functional Characterization of VanG d-Ala:d-Ser Ligase Associated with Vancomycin Resistance inEnterococcus faecalis

(2012) Djalal Meziane-Cherif et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of the β5–α11 Loop in the Active-Site Dynamics of Acylated Penicillin-Binding Protein A from Mycobacterium tuberculosis

(2012) Alena Fedarovich et al.   JOURNAL OF MOLECULAR BIOLOGY

New Delhi Metallo-β-Lactamase: Structural Insights into β-Lactam Recognition and Inhibition

(2012) Dustin T. King et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mutations in Streptococcus pneumoniae Penicillin-Binding Protein 2x: Importance of the C-Terminal Penicillin-Binding Protein and Serine/Threonine Kinase-Associated Domains for Beta-Lactam Binding

(2012) Patrick Maurer et al.   Microbial Drug Resistance

Streptococcus pneumoniaeR6 interspecies transformation: genetic analysis of penicillin resistance determinants and genome-wide recombination events

(2012) Julia Sauerbier et al.   MOLECULAR MICROBIOLOGY

Development of New Drugs for an Old Target — The Penicillin Binding Proteins

(2012) Astrid Zervosen et al.   MOLECULES

High-Throughput Screening for Novel Inhibitors of Neisseria gonorrhoeae Penicillin-Binding Protein 2

(2012) Alena Fedarovich et al.   PLoS One

A Point Mutation in cycA Partially Contributes to the D-cycloserine Resistance Trait of Mycobacterium bovis BCG Vaccine Strains

(2012) Jeffrey M. Chen et al.   PLoS One

The Nonantibiotic Small Molecule Cyslabdan Enhances the Potency of β-Lactams against MRSA by Inhibiting Pentaglycine Interpeptide Bridge Synthesis

(2012) Nobuhiro Koyama et al.   PLoS One

Targeting the Cell Wall of Mycobacterium tuberculosis: Structure and Mechanism of L,D-Transpeptidase 2

(2012) Sabri B. Erdemli et al.   STRUCTURE

4-Quinolones as Noncovalent Inhibitors of High Molecular Mass Penicillin-Binding Proteins

(2012) Abbas G. Shilabin et al.   ACS Medicinal Chemistry Letters

Structure-Guided Design of Cell Wall Biosynthesis Inhibitors That Overcome β-Lactam Resistance inStaphylococcus aureus(MRSA)

(2011) Carlos Contreras-Martel et al.   ACS Chemical Biology

Structure of New Delhi metallo-β-lactamase 1 (NDM-1)

(2011) Victoria L. Green et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

A boronic-acid-based probe for fluorescence polarization assays with penicillin binding proteins and β-lactamases

(2011) Steven R. Inglis et al.   ANALYTICAL BIOCHEMISTRY

AmpG Inactivation Restores Susceptibility of Pan-β-Lactam-Resistant Pseudomonas aeruginosa Clinical Strains

(2011) Laura Zamorano et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

UDP-N-acetylglucosamine enolpyruvyl transferase as a potential target for antibacterial chemotherapy: recent developments

(2011) Ankur Gautam et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Lyme Disease Enolpyruvyl-UDP-GlcNAc Synthase: Fosfomycin-Resistant MurA fromBorrelia burgdorferi, a Fosfomycin-Sensitive Mutant, and the Catalytic Role of the Active Site Asp

(2011) Shan Jiang et al.   BIOCHEMISTRY

Interaction of fosfomycin with the Glycerol 3-phosphate Transporter of Escherichia coli

(2011) Antonella Santoro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Challenges of Antibacterial Discovery

(2011) L. L. Silver   CLINICAL MICROBIOLOGY REVIEWS

Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane

(2011) Tamimount Mohammadi et al.   EMBO JOURNAL

Crystal structure of NDM-1 reveals a common β-lactam hydrolysis mechanism

(2011) HongMin Zhang et al.   FASEB JOURNAL

Fosfomycin: evaluation of the published evidence on the emergence of antimicrobial resistance in Gram-negative pathogens

(2011) D. E. Karageorgopoulos et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Virtual screening for potential inhibitors of bacterial MurC and MurD ligases

(2011) Tihomir Tomašić et al.   JOURNAL OF MOLECULAR MODELING

Unexpected Tricovalent Binding Mode of Boronic Acids within the Active Site of a Penicillin-Binding Protein

(2011) Astrid Zervosen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metallo-β-lactamases: a last frontier for β-lactams?

(2011) Giuseppe Cornaglia et al.   LANCET INFECTIOUS DISEASES

Molecular Basis of NDM-1, a New Antibiotic Resistance Determinant

(2011) Zhongjie Liang et al.   PLoS One

The emerging NDM carbapenemases

(2011) Patrice Nordmann et al.   TRENDS IN MICROBIOLOGY

ampG Gene of Pseudomonas aeruginosa and Its Role in  -Lactamase Expression

(2010) Y. Zhang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Fungal Product Terreic Acid Is a Covalent Inhibitor of the Bacterial Cell Wall Biosynthetic Enzyme UDP-N-Acetylglucosamine 1-Carboxyvinyltransferase (MurA),

(2010) Huijong Han et al.   BIOCHEMISTRY

Bridging cell wall biosynthesis and bacterial morphogenesis

(2010) Pierre-Jean Matteï et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

New Lipoglycopeptides

(2010) George G. Zhanel et al.   DRUGS

Molecular mechanisms of fosfomycin resistance in clinical isolates of Escherichia coli

(2010) Sho Takahata et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Chequerboard titration of cephalosporin CXA-101 (FR264205) and tazobactam versus  -lactamase-producing Enterobacteriaceae

(2010) D. M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Discovery of Novel 5-Benzylidenerhodanine and 5-Benzylidenethiazolidine-2,4-dione Inhibitors of MurD Ligase

(2010) Nace Zidar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Basis for the Interaction of Lactivicins with Serine β-Lactamases

(2010) Tom Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

Unusual Conformation of the SxN Motif in the Crystal Structure of Penicillin-Binding Protein A from Mycobacterium tuberculosis

(2010) Alena Fedarovich et al.   JOURNAL OF MOLECULAR BIOLOGY

Interactions Between Late-Acting Proteins Required for Peptidoglycan Synthesis during Sporulation

(2010) Allison Fay et al.   JOURNAL OF MOLECULAR BIOLOGY

Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study

(2010) Karthikeyan K Kumarasamy et al.   LANCET INFECTIOUS DISEASES

Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis

(2010) José A Caminero et al.   LANCET INFECTIOUS DISEASES

Induction of  -lactamase production in Aeromonas hydrophila is responsive to  -lactam-mediated changes in peptidoglycan composition

(2010) A. E. Tayler et al.   MICROBIOLOGY-SGM

Positioning cell wall synthetic complexes by the bacterial morphogenetic proteins MreB and MreD

(2010) Courtney L. White et al.   MOLECULAR MICROBIOLOGY

The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin

(2010) Radhika Gupta et al.   NATURE MEDICINE

Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa

(2010) S. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MurF Inhibitors with Antibacterial Activity: Effect on Muropeptide Levels

(2009) E. Z. Baum et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Diversity, Epidemiology, and Genetics of Class D  -Lactamases

(2009) L. Poirel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Updated Functional Classification of  -Lactamases

(2009) K. Bush et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mutation of the Active Site Carboxy-Lysine (K70) of OXA-1 β-Lactamase Results in a Deacylation-Deficient Enzyme

(2009) Kyle D. Schneider et al.   BIOCHEMISTRY

Discovery of novel benzene 1,3-dicarboxylic acid inhibitors of bacterial MurD and MurE ligases by structure-based virtual screening approach

(2009) Andrej Perdih et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phosphorylated hydroxyethylamines as novel inhibitors of the bacterial cell wall biosynthesis enzymes MurC to MurF

(2009) Matej Sova et al.   BIOORGANIC CHEMISTRY

AmpC  -Lactamases

(2009) G. A. Jacoby   CLINICAL MICROBIOLOGY REVIEWS

Activity of the siderophore monobactam BAL30072 against multiresistant non-fermenters

(2009) S. Mushtaq et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The Glycerol-3-Phosphate Permease GlpT Is the Only Fosfomycin Transporter in Pseudomonas aeruginosa

(2009) A. Castaneda-Garcia et al.   JOURNAL OF BACTERIOLOGY

PBP Active Site Flexibility as the Key Mechanism for β-Lactam Resistance in Pneumococci

(2009) Carlos Contreras-Martel et al.   JOURNAL OF MOLECULAR BIOLOGY

Antimicrobial nucleoside antibiotics targeting cell wall assembly: Recent advances in structure–function studies and nucleoside biosynthesis

(2009) Michael Winn et al.   NATURAL PRODUCT REPORTS

Aminoacyl-tRNA recognition by the FemXWv transferase for bacterial cell wall synthesis

(2009) M. Fonvielle et al.   NUCLEIC ACIDS RESEARCH

Genetic and Structural Insights into the Dissemination Potential of the Extremely Broad-Spectrum Class A  -Lactamase KPC-2 Identified in an Escherichia coli Strain and an Enterobacter cloacae Strain Isolated from the Same Patient in France

(2008) S. Petrella et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of an Inhibitor of the MurC Enzyme, Which Catalyzes an Essential Step in the Peptidoglycan Precursor Synthesis Pathway

(2008) Laura E. Zawadzke et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Synthesis and biological evaluation of new glutamic acid-based inhibitors of MurD ligase

(2008) Tihomir Tomašić et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Are natural products still the best source for antibacterial discovery? The bacterial entry factor

(2008) Lynn L Silver   Expert Opinion on Drug Discovery

Crystal Structure of Fosfomycin Resistance Kinase FomA fromStreptomyces wedmorensis

(2008) Svetlana Pakhomova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of UDP-N-acetylglucosamine enolpyruvyl transferase fromHaemophilus influenzae in complex with UDP-N-acetylglucosamine and fosfomycin

(2008) Hye-Jin Yoon et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The Three-Dimensional Structure of VIM-2, a Zn-β-Lactamase from Pseudomonas aeruginosa in Its Reduced and Oxidised Form

(2007) I. Garcia-Saez et al.   JOURNAL OF MOLECULAR BIOLOGY