Metallo-β-lactamase structure and function

A Potential Substrate Binding Conformation of β-Lactams and Insight into the Broad Spectrum of NDM-1 Activity

(2012) Qinghui Yuan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mutagenesis of Zinc Ligand Residue Cys221 Reveals Plasticity in the IMP-1 Metallo-β-Lactamase Active Site

(2012) Lori B. Horton et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Crystal Structure of the Mobile Metallo-β-Lactamase AIM-1 from Pseudomonas aeruginosa: Insights into Antibiotic Binding and the Role of Gln157

(2012) Hanna-Kirsti S. Leiros et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanistic and Spectroscopic Studies of Metallo-β-lactamase NDM-1

(2012) Hao Yang et al.   BIOCHEMISTRY

Molecular mechanisms of β-lactam resistance inStreptococcus pneumoniae

(2012) Regine Hakenbeck et al.   Future Microbiology

Fourteen years in resistance

(2012) David M. Livermore   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

New Delhi Metallo-β-Lactamase: Structural Insights into β-Lactam Recognition and Inhibition

(2012) Dustin T. King et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analysis of the Functional Contributions of Asn233 in Metallo-β-Lactamase IMP-1

(2011) Nicholas G. Brown et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Carbapenems: Past, Present, and Future

(2011) Krisztina M. Papp-Wallace et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural and Kinetic Studies on Metallo-β-lactamase IMP-1

(2011) Dionne H. Griffin et al.   BIOCHEMISTRY

Crystal structure of NDM-1 reveals a common β-lactam hydrolysis mechanism

(2011) HongMin Zhang et al.   FASEB JOURNAL

Structural and Computational Investigations of VIM-7: Insights into the Substrate Specificity of VIM Metallo-β-Lactamases

(2011) Pardha Saradhi Borra et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structure of Serratia fonticola Sfh-I: Activation of the Nucleophile in Mono-Zinc Metallo-β-Lactamases

(2011) Fátima Fonseca et al.   JOURNAL OF MOLECULAR BIOLOGY

A Computational Evaluation of the Mechanism of Penicillin-Binding Protein-Catalyzed Cross-Linking of the Bacterial Cell Wall

(2011) Qicun Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metallo-β-lactamases: a last frontier for β-lactams?

(2011) Giuseppe Cornaglia et al.   LANCET INFECTIOUS DISEASES

Structure of Apo- and Monometalated Forms of NDM-1—A Highly Potent Carbapenem-Hydrolyzing Metallo-β-Lactamase

(2011) Youngchang Kim et al.   PLoS One

Crystal structure of New Delhi metallo-β-lactamase reveals molecular basis for antibiotic resistance

(2011) Dustin King et al.   PROTEIN SCIENCE

The emerging NDM carbapenemases

(2011) Patrice Nordmann et al.   TRENDS IN MICROBIOLOGY

The coming of age of antibiotics: discovery and therapeutic value

(2010) Karen Bush   Annals of the New York Academy of Sciences

Epidemiological Expansion, Structural Studies, and Clinical Challenges of New β-Lactamases from Gram-Negative Bacteria

(2010) Karen Bush et al.   Annual Review of Microbiology

Mechanistic Studies of the Inactivation of TEM-1 and P99 by NXL104, a Novel Non- -Lactam  -Lactamase Inhibitor

(2010) T. Stachyra et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biochemical and Structural Characterization of the Subclass B1 Metallo-β-Lactamase VIM-4

(2010) Patricia Lassaux et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High-Resolution Crystal Structure of the Subclass B3 Metallo- -Lactamase BJP-1: Rational Basis for Substrate Specificity and Interaction with Sulfonamides

(2010) J.-D. Docquier et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biochemical and Structural Characterization ofMycobacterium tuberculosisβ-Lactamase with the Carbapenems Ertapenem and Doripenem

(2010) Lee W. Tremblay et al.   BIOCHEMISTRY

Three Decades of  -Lactamase Inhibitors

(2010) S. M. Drawz et al.   CLINICAL MICROBIOLOGY REVIEWS

Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae

(2010) Karen Bush   CURRENT OPINION IN MICROBIOLOGY

A role for flexible loops in enzyme catalysis

(2010) M Merced Malabanan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Spectroscopic signature of a ubiquitous metal binding site in the metallo-β-lactamase superfamily

(2010) Valeria A. Campos-Bermudez et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

QM/MM Studies of Monozinc β-Lactamase CphA Suggest That the Crystal Structure of an Enzyme−Intermediate Complex Represents a Minor Pathway

(2010) Shanshan Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Structure of the Dizinc Subclass B2 Metallo- -Lactamase CphA Reveals that the Second Inhibitory Zinc Ion Binds in the Histidine Site

(2009) C. Bebrone et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization of a New Metallo- -Lactamase Gene, blaNDM-1, and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India

(2009) D. Yong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

β-Lactamase Inhibitors: The Story so Far

(2009) Francisco Perez-Llarena et al.   CURRENT MEDICINAL CHEMISTRY

Common Mechanistic Features among Metallo-β-lactamases

(2009) Fabio Simona et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Positively Cooperative Binding of Zinc Ions to Bacillus cereus 569/H/9 β-Lactamase II Suggests that the Binuclear Enzyme Is the Only Relevant Form for Catalysis

(2009) Olivier Jacquin et al.   JOURNAL OF MOLECULAR BIOLOGY

Differential Binding of Co(II) and Zn(II) to Metallo-β-Lactamase Bla2 fromBacillus anthracis

(2009) Megan J. Hawk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mutational analysis of the zinc- and substrate-binding sites in the CphA metallo-β-lactamase fromAeromonas hydrophila

(2008) Carine Bebrone et al.   BIOCHEMICAL JOURNAL

Plasmid encoded antibiotic resistance: acquisition and transfer of antibiotic resistance genes in bacteria

(2008) P M Bennett   BRITISH JOURNAL OF PHARMACOLOGY

Loss of enzyme activity during turnover of the Bacillus cereus β-lactamase catalysed hydrolysis of β-lactams due to loss of zinc ion

(2008) Adriana Badarau et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Inhibition of Class A β-Lactamases by Carbapenems: Crystallographic Observation of Two Conformations of Meropenem in SHV-1

(2008) Michiyosi Nukaga et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Trapping and Characterization of a Reaction Intermediate in Carbapenem Hydrolysis byB. cereusMetallo-β-lactamase

(2008) Mariana F. Tioni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Adaptive protein evolution grants organismal fitness by improving catalysis and flexibility

(2008) P. E. Tomatis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Three-Dimensional Structure of VIM-2, a Zn-β-Lactamase from Pseudomonas aeruginosa in Its Reduced and Oxidised Form

(2007) I. Garcia-Saez et al.   JOURNAL OF MOLECULAR BIOLOGY