The 2012 Garrod Lecture: Discovery of antibacterial drugs in the 21st century

Structure-based design and screening of inhibitors for an essential bacterial GTPase, Der

(2012) Jihwan Hwang et al.   JOURNAL OF ANTIBIOTICS

The ticking time bomb: escalating antibiotic resistance in Neisseria gonorrhoeae is a public health disaster in waiting

(2012) D. M. Whiley et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

2012 and beyond: potential for the start of a second pre-antibiotic era?

(2012) P. C. Appelbaum   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas aeruginosa Thymidylate Kinase: From Hit to Lead Generation

(2012) Jun Yong Choi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recover the lost art of drug discovery

(2012) Kim Lewis   NATURE

Further Characterization ofBacillus subtilisAntibiotic Biosensors and Their Use for Antibacterial Mode-of-Action Studies

(2011) Katherine R. Mariner et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Challenges of Antibacterial Discovery

(2011) L. L. Silver   CLINICAL MICROBIOLOGY REVIEWS

The global need for effective antibiotics—A summary of plenary presentations

(2011) Gunnar Alvan et al.   DRUG RESISTANCE UPDATES

The global need for effective antibiotics—Moving towards concerted action

(2011) Otto Cars et al.   DRUG RESISTANCE UPDATES

Evaluating the activity of the RNA polymerase inhibitor myxopyronin B against Staphylococcus aureus

(2011) Terence I. Moy et al.   FEMS MICROBIOLOGY LETTERS

Antibiotics in the clinical pipeline in 2011

(2011) Mark S Butler et al.   JOURNAL OF ANTIBIOTICS

Effective antibacterials: at what cost? The economics of antibacterial resistance and its control

(2011) A. R. White et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Regulatory opportunities to encourage technology solutions to antibacterial drug resistance

(2011) R. Finch et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The urgent need for new antibacterial agents

(2011) R. Wise et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Discovery research: the scientific challenge of finding new antibiotics

(2011) D. M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The crisis of no new antibiotics—what is the way forward?

(2011) Laura JV Piddock   LANCET INFECTIOUS DISEASES

Bacterial cell wall assembly: still an attractive antibacterial target

(2011) Timothy D.H. Bugg et al.   TRENDS IN BIOTECHNOLOGY

Structure-Based Ligand Design of Novel Bacterial RNA Polymerase Inhibitors

(2011) Martin J. McPhillie et al.   ACS Medicinal Chemistry Letters

Structure-based design of anti-infectives

(2010) Anil K Agarwal et al.   Annals of the New York Academy of Sciences

Challenges of antibacterial discovery revisited

(2010) Michael N. Gwynn et al.   Annals of the New York Academy of Sciences

Approaches to Capturing and Designing Biologically Active Small Molecules Produced by Uncultured Microbes

(2010) Jörn Piel   Annual Review of Microbiology

Furanyl-Rhodanines Are Unattractive Drug Candidates for Development as Inhibitors of Bacterial RNA Polymerase

(2010) K. R. Mariner et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Recent application of metagenomic approaches toward the discovery of antimicrobials and other bioactive small molecules

(2010) Jacob J Banik et al.   CURRENT OPINION IN MICROBIOLOGY

Positioning cell wall synthetic complexes by the bacterial morphogenetic proteins MreB and MreD

(2010) Courtney L. White et al.   MOLECULAR MICROBIOLOGY

The antibacterial lead discovery challenge

(2010)   NATURE REVIEWS DRUG DISCOVERY

Structure-based discovery of antibacterial drugs

(2010) Katie J. Simmons et al.   NATURE REVIEWS MICROBIOLOGY

Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches

(2009) Igor Mochalkin et al.   ACS Chemical Biology

Is drug release necessary for antimicrobial activity of siderophore-drug conjugates? Syntheses and biological studies of the naturally occurring salmycin “Trojan Horse” antibiotics and synthetic desferridanoxamine-antibiotic conjugates

(2009) Timothy A. Wencewicz et al.   BIOMETALS

Has the era of untreatable infections arrived?

(2009) D. M. Livermore   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Tackling antibiotic resistance: a dose of common antisense?

(2008) N. Woodford et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

(2008) Rosemarie O’Shea et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transcription inactivation through local refolding of the RNA polymerase structure

(2008) Georgiy A. Belogurov et al.   NATURE