CEACAM1 Negatively Regulates IL-1β Production in LPS Activated Neutrophils by Recruiting SHP-1 to a SYK-TLR4-CEACAM1 Complex

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Inhibits Proximal TCR Signaling by Targeting ZAP-70

(2014) Zhangguo Chen et al.   JOURNAL OF IMMUNOLOGY

CEACAM1 Dynamics during Neisseria gonorrhoeae Suppression of CD4+ T Lymphocyte Activation

(2014) H. S. W. Lee et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential Expression of NLRP3 among Hematopoietic Cells

(2011) G. Guarda et al.   JOURNAL OF IMMUNOLOGY

Carcinoembryonic Antigen-Related Cell Adhesion Molecule-1 Regulates Granulopoiesis by Inhibition of Granulocyte Colony-Stimulating Factor Receptor

(2010) Hao Pan et al.   IMMUNITY

Anti-inflammatory actions of Syk inhibitors in macrophages involve non-specific inhibition of toll-like receptors-mediated JNK signaling pathway

(2010) Ying-Cing Lin et al.   MOLECULAR IMMUNOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ

(2010) Li-Chung Hsu et al.   NATURE IMMUNOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection

(2009) J. A. Van Ziffle et al.   BLOOD

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

Pivotal Advance: CEACAM1 is a negative coreceptor for the B cell receptor and promotes CD19-mediated adhesion of B cells in a PI3K-dependent manner

(2009) Elizabeth O. Lobo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

(2009) Olaf Gross et al.   NATURE

Cross-Talk between TLR4 and FcγReceptorIII (CD16) Pathways

(2009) Daniel Rittirsch et al.   PLoS Pathogens

Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

(2009) Marina Tiemi Shio et al.   PLoS Pathogens

The Caspase-1 Inflammasome: A Pilot of Innate Immune Responses

(2008) Hong Bing Yu et al.   Cell Host & Microbe

When Signaling Pathways Collide: Positive and Negative Regulation of Toll-like Receptor Signal Transduction

(2008) Luke A.J. O'Neill   IMMUNITY

CEACAM1 inhibits Toll-like receptor 2–triggered antibacterial responses of human pulmonary epithelial cells

(2008) Hortense Slevogt et al.   NATURE IMMUNOLOGY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY