Calcium sensitive ring-like oligomers formed by synaptotagmin

The Juxtamembrane Linker of Full-length Synaptotagmin 1 Controls Oligomerization and Calcium-dependent Membrane Binding

(2014) Bin Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Linker mutations reveal the complexity of synaptotagmin 1 action during synaptic transmission

(2014) Huisheng Liu et al.   NATURE NEUROSCIENCE

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

(2014) B. G. Wilhelm et al.   SCIENCE

Conformational Dynamics of Calcium-Triggered Activation of Fusion by Synaptotagmin

(2013) Shyam S. Krishnakumar et al.   BIOPHYSICAL JOURNAL

Complexin Activates Exocytosis of Distinct Secretory Vesicles Controlled by Different Synaptotagmins

(2013) P. Cao et al.   JOURNAL OF NEUROSCIENCE

Synaptotagmin Interaction with SNAP-25 Governs Vesicle Docking, Priming, and Fusion Triggering

(2013) R. Mohrmann et al.   JOURNAL OF NEUROSCIENCE

Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment

(2013) Alf Honigmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Prevalent mechanism of membrane bridging by synaptotagmin-1

(2013) Alpay B. Seven et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution single-vesicle assay reveals PIP2-mediated sequential actions of synaptotagmin-1 on SNAREs

(2012) Jae-Yeol Kim et al.   EMBO JOURNAL

Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release

(2012) Jörg Malsam et al.   EMBO JOURNAL

SNAREpin Assembly by Munc18-1 Requires Previous Vesicle Docking by Synaptotagmin 1

(2012) Daniel Parisotto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium Binding by Synaptotagmin's C2A Domain is an Essential Element of the Electrostatic Switch That Triggers Synchronous Synaptic Transmission

(2012) A. R. Striegel et al.   JOURNAL OF NEUROSCIENCE

Complexin Controls Spontaneous and Evoked Neurotransmitter Release by Regulating the Timing and Properties of Synaptotagmin Activity

(2012) R. A. Jorquera et al.   JOURNAL OF NEUROSCIENCE

Real-space processing of helical filaments in SPARX

(2012) Elmar Behrmann et al.   JOURNAL OF STRUCTURAL BIOLOGY

Calcium cooperativity of exocytosis as a measure of Ca2+ channel domain overlap

(2011) Victor Matveev et al.   BRAIN RESEARCH

Complexin Maintains Vesicles in the Primed State in C. elegans

(2011) Robert J. Hobson et al.   CURRENT BIOLOGY

Complexin Has Opposite Effects on Two Modes of Synaptic Vesicle Fusion

(2011) Jesse A. Martin et al.   CURRENT BIOLOGY

Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion

(2011) Zhao Wang et al.   JOURNAL OF CELL BIOLOGY

Membrane Penetration by Synaptotagmin Is Required for Coupling Calcium Binding to Vesicle Fusion In Vivo

(2011) B. E. Paddock et al.   JOURNAL OF NEUROSCIENCE

Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation

(2011) Geert van den Bogaart et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion

(2011) Shyam S Krishnakumar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complexin cross-links prefusion SNAREs into a zigzag array

(2011) Daniel Kümmel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism and function of synaptotagmin-mediated membrane apposition

(2011) Enfu Hui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release

(2010) Richard W. Cho et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Single-molecule FRET–derived model of the synaptotagmin 1–SNARE fusion complex

(2010) Ucheor B Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor Complexes

(2009) Heidi de Wit et al.   CELL

Synaptotagmin-Mediated Bending of the Target Membrane Is a Critical Step in Ca2+-Regulated Fusion

(2009) Enfu Hui et al.   CELL

The Calcium-Dependent and Calcium-Independent Membrane Binding of Synaptotagmin 1: Two Modes of C2B Binding

(2009) Weiwei Kuo et al.   JOURNAL OF MOLECULAR BIOLOGY

Tilting the Balance between Facilitatory and Inhibitory Functions of Mammalian and Drosophila Complexins Orchestrates Synaptic Vesicle Exocytosis

(2009) Mingshan Xue et al.   NEURON

How Does Synaptotagmin Trigger Neurotransmitter Release?

(2008) Edwin R. Chapman   Annual Review of Biochemistry

The Affinity Grid: A Pre-fabricated EM Grid for Monolayer Purification

(2008) Deborah F. Kelly et al.   JOURNAL OF MOLECULAR BIOLOGY

Ca2+-Dependent, Phospholipid-Binding Residues of Synaptotagmin Are Critical for Excitation-Secretion Coupling In Vivo

(2008) B. E. Paddock et al.   JOURNAL OF NEUROSCIENCE

SNARE Function Is Not Involved in Early Endosome Docking

(2008) Ulf Geumann et al.   MOLECULAR BIOLOGY OF THE CELL

Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+

(2008) Michael C Chicka et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The molecular mechanism of lipid monolayer collapse

(2008) S. Baoukina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA