Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation

Synaptobrevin N-terminally bound to syntaxin–SNAP-25 defines the primed vesicle state in regulated exocytosis

(2010) Alexander M. Walter et al.   JOURNAL OF CELL BIOLOGY

Molecular mechanism of the synaptotagmin–SNARE interaction in Ca2+-triggered vesicle fusion

(2010) Marija Vrljic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

One SNARE complex is sufficient for membrane fusion

(2010) Geert van den Bogaart et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Single-molecule FRET–derived model of the synaptotagmin 1–SNARE fusion complex

(2010) Ucheor B Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fast Vesicle Fusion in Living Cells Requires at Least Three SNARE Complexes

(2010) R. Mohrmann et al.   SCIENCE

Dynamic Ca2+-Dependent Stimulation of Vesicle Fusion by Membrane-Anchored Synaptotagmin 1

(2010) H. K. Lee et al.   SCIENCE

Protein-binding assays in biological liquids using microscale thermophoresis

(2010) Christoph J. Wienken et al.   Nature Communications

Single-Molecule Studies of the Neuronal SNARE Fusion Machinery

(2009) Axel T. Brunger et al.   Annual Review of Biochemistry

Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor Complexes

(2009) Heidi de Wit et al.   CELL

Synaptotagmin-Mediated Bending of the Target Membrane Is a Critical Step in Ca2+-Regulated Fusion

(2009) Enfu Hui et al.   CELL

The Ca2+Affinity of Synaptotagmin 1 Is Markedly Increased by a Specific Interaction of Its C2B Domain with Phosphatidylinositol 4,5-Bisphosphate

(2009) Anand Radhakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How Does Synaptotagmin Trigger Neurotransmitter Release?

(2008) Edwin R. Chapman   Annual Review of Biochemistry

Synaptic Vesicles Are Constitutively Active Fusion Machines that Function Independently of Ca 2+

(2008) Matthew Holt et al.   CURRENT BIOLOGY

Synaptotagmin C2B Domain Regulates Ca2+-triggered Fusionin Vitro

(2008) Jon D. Gaffaney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol 4,5-bisphosphate regulates SNARE-dependent membrane fusion

(2008) Declan J. James et al.   JOURNAL OF CELL BIOLOGY

The MARTINI Coarse-Grained Force Field: Extension to Proteins

(2008) Luca Monticelli et al.   Journal of Chemical Theory and Computation

Mechanisms of membrane fusion: disparate players and common principles

(2008) Sascha Martens et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+

(2008) Michael C Chicka et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Janus-faced nature of the C2B domain is fundamental for synaptotagmin-1 function

(2008) Mingshan Xue et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion

(2008) Stefan H. Gerber et al.   SCIENCE