Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment

Molecular Level Interaction of Inositol Hexaphosphate with the C2B Domain of Human Synaptotagmin I

(2012) Meng-Je Joung et al.   BIOCHEMISTRY

Solution single-vesicle assay reveals PIP2-mediated sequential actions of synaptotagmin-1 on SNAREs

(2012) Jae-Yeol Kim et al.   EMBO JOURNAL

Phosphatidylinositol 4,5-Bisphosphate Increases Ca2+Affinity of Synaptotagmin-1 by 40-fold

(2012) Geert van den Bogaart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular machines governing exocytosis of synaptic vesicles

(2012) Reinhard Jahn et al.   NATURE

Post-Translational Modifications and Lipid Binding Profile of Insect Cell-Expressed Full-Length Mammalian Synaptotagmin 1

(2011) Marija Vrljic et al.   BIOCHEMISTRY

Phosphatidylinositol 4,5-Bisphosphate Alters Synaptotagmin 1 Membrane Docking and Drives Opposing Bilayers Closer Together

(2011) Weiwei Kuo et al.   BIOCHEMISTRY

STED Nanoscopy Reveals Molecular Details of Cholesterol- and Cytoskeleton-Modulated Lipid Interactions in Living Cells

(2011) V. Mueller et al.   BIOPHYSICAL JOURNAL

Membrane protein sequestering by ionic protein–lipid interactions

(2011) Geert van den Bogaart et al.   NATURE

Sharper low-power STED nanoscopy by time gating

(2011) Giuseppe Vicidomini et al.   NATURE METHODS

Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation

(2011) Geert van den Bogaart et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism and function of synaptotagmin-mediated membrane apposition

(2011) Enfu Hui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Membrane docking of the C2 domain from protein kinase Cα as seen by polarized ATR-IR. The role of PIP2

(2010) Alessio Ausili et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Membrane Curvature in Synaptic Vesicle Fusion and Beyond

(2010) Harvey T. McMahon et al.   CELL

Membrane Docking Geometry and Target Lipid Stoichiometry of Membrane-Bound PKCα C2 Domain: A Combined Molecular Dynamics and Experimental Study

(2010) Chun-Liang Lai et al.   JOURNAL OF MOLECULAR BIOLOGY

Synaptotagmin 1 and SNAREs Form a Complex That Is Structurally Heterogeneous

(2010) Alex L. Lai et al.   JOURNAL OF MOLECULAR BIOLOGY

One SNARE complex is sufficient for membrane fusion

(2010) Geert van den Bogaart et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Single-molecule FRET–derived model of the synaptotagmin 1–SNARE fusion complex

(2010) Ucheor B Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Calcium-Dependent Lateral Organization in Phosphatidylinositol 4,5-Bisphosphate (PIP2)- and Cholesterol-Containing Monolayers

(2009) Ilya Levental et al.   BIOCHEMISTRY

Configuration of PKCα-C2 Domain Bound to Mixed SOPC/SOPS Lipid Monolayers

(2009) Chiu-Hao Chen et al.   BIOPHYSICAL JOURNAL

Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor Complexes

(2009) Heidi de Wit et al.   CELL

Red-Emitting Rhodamine Dyes for Fluorescence Microscopy and Nanoscopy

(2009) Kirill Kolmakov et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Ca2+Affinity of Synaptotagmin 1 Is Markedly Increased by a Specific Interaction of Its C2B Domain with Phosphatidylinositol 4,5-Bisphosphate

(2009) Anand Radhakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and mechanistic insights into the association of PKC -C2 domain to PtdIns(4,5)P2

(2009) M. Guerrero-Valero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

How Does Synaptotagmin Trigger Neurotransmitter Release?

(2008) Edwin R. Chapman   Annual Review of Biochemistry

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Cross-linking of Phospholipid Membranes is a Conserved Property of Calcium-sensitive Synaptotagmins

(2008) Emma Connell et al.   JOURNAL OF MOLECULAR BIOLOGY

Direct observation of the nanoscale dynamics of membrane lipids in a living cell

(2008) Christian Eggeling et al.   NATURE

The Janus-faced nature of the C2B domain is fundamental for synaptotagmin-1 function

(2008) Mingshan Xue et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The PIP2 binding mode of the C2 domains of rabphilin-3A

(2008) Pierre Montaville et al.   PROTEIN SCIENCE

Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain

(2004) Yuan Cheng et al.   PROTEIN SCIENCE